Protective Effects of Exogenous Melatonin Administration on White Fat Metabolism Disruption Induced by Aging and a High-Fat Diet in Mice DOI Creative Commons

Dongying Lv,

Yujie Ren,

Jiayan Chen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1500 - 1500

Published: Dec. 9, 2024

Obesity has emerged as a major risk factor for human health, exacerbated by aging and changes in dietary habits. It represents significant health challenge, particularly older people. While numerous studies have examined the effects of obesity on fat metabolism independently, research their combined is limited. In present study, protective action against white accumulation after high-fat diet (HFD) exerted exogenous melatonin, circadian hormone endowed with antioxidant properties also involved metabolism, was investigated mouse model. For this purpose, battery tests applied before melatonin treatments animals, including epididymal adipose tissue (eWAT) histological evaluations, transcriptomic lipidomic analyses, real-time PCR tests, immunofluorescence staining, Western blot, appraisal serum levels, transmission electron microscopy. This study found that aged mice showed increased lipid deposition, inflammation, reduced glutathione (GSH) levels compared to younger mice. Lipidomic analyses revealed elevated triglycerides, diglycerides, ceramides, cholesterol, along decreased sphingomyelin fatty acids eWAT. The genes linked NF-κB signaling, autophagy, pathways, were significantly altered. HFD exhibited Melatonin supplementation GSH upregulated AANAT MTNR1A expression eWAT, suggesting alleviates eWAT damage via pathway. suppressed inflammatory markers (e.g., TNF-α, NLRP3, NF-κB, IL-1β, CEBPB) preserved mitochondrial function through enhanced mitophagy. highlights how affect gene expression, offering potential intervention strategies. These findings provide important insights into mechanisms deposition associated diet,

Language: Английский

Tailored carbon materials (TCM) for enhancing photocatalytic degradation of polyaromatic hydrocarbons DOI Creative Commons
Avtar Singh, Jaspreet S. Dhau, Rajeev Kumar

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101289 - 101289

Published: March 28, 2024

This comprehensive review explores the potential of tailored carbon materials (TCM) for efficient photocatalytic degradation polyaromatic hydrocarbons (PAHs), which are persistent and toxic organic pollutants posing significant environmental challenges. The unique structure properties TCM including graphene nanotubes to activated dots, have projected them as next-generation technological innovation. A careful critical discussion state-of-the-art research sheds light on their effectiveness in catalyzing breakdown PAHs, projects suitable management environment. Beyond this viewpoint, article expands scope 1) biomedical healthcare, 2) energy storage conversion, 3) advanced electronics. challenges, opportunities, future perspectives related role applications, inspiring further research, innovation photo-induced techniques also carefully discussed article. focused serves a valuable resource researchers industrialists interested harnessing capabilities carbon-based sustainable PAHs other pollutants. It addresses pressing need effective remediation pollution control strategies.

Language: Английский

Citations

30
Redox and inflammatory mechanisms linking air pollution particulate matter with cardiometabolic derangements DOI
Timoteo Marchini

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 209, P. 320 - 341

Published: Oct. 16, 2023

Language: Английский

Citations

18
Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice DOI Creative Commons
Dunia Waked,

G. H. Guedes,

Rubens Arantes Macedo

et al.

Atmosphere, Journal Year: 2025, Volume and Issue: 16(1), P. 109 - 109

Published: Jan. 19, 2025

Background: Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM), a major component air pollution, is associated with the development cardiovascular diseases (CVDs). Cellular senescence other aging mechanisms are also key factors in progression CVD. This study aims to investigate age-related susceptibility cardiac remodeling due PM exposure. Methods: Young old male C57BL/6 mice were exposed filtered or polluted for six months using an ambient particle concentrator. Cardiac hypertrophy, fibrosis, markers cellular (p53, p21, p-H2AX, lipofuscin) myocardium evaluated experimental groups. Results: exposure induces signs remodeling, including cardiomyocyte enlargement increased young mice, along elevated p53 expression. However, no significant alterations structure observed between aged not PM. Conclusions: Our indicates younger individuals may be more vulnerable effects chronic than older later. Further needed explore detailed this age-dependent response.

Language: Английский

Citations

0
A Study of Air Quality Modeling Based on Transportation Sources through Bibliometric Analysis DOI Open Access
Rachmanu Eko Handriyono, Joni Hermana, Abdu Fadli Assomadi

et al.

IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1448(1), P. 012008 - 012008

Published: Feb. 1, 2025

Abstract Air quality models refer to mathematical representations or computer simulations of the distribution and changes in concentration air pollutants specific areas locations over time. The aim this research is map current global state future development trends modeling studies based on transportation sources. results mapping will serve as a foundation for identifying novelty topic pollutant dispersion from This study employs bibliometric approach by analyzing 1,122 scientific publications half century using Scopus database. findings indicate that Atmospheric Environment United States are most productive publication sources country, respectively, field sector. VOS viewer version 1.6.19 show out 8,590 keywords, 371 keywords were considered meet criteria. clustering interconnection between keywords. more connected keyword is, has been conducted keyword. several computational can be further developed purposes. These include AERMOD, CALINE4, WRF-Chem, CFD (Computational Fluid Dynamics). computing have their respective advantages disadvantages. In summary, needed develop simpler yet computationally efficient integrate atmospheric chemical reactions obstacle factors while maintaining high accuracy.

Language: Английский

Citations

0
Particulate matter 2.5 accelerates aging: Exploring cellular senescence and age-related diseases DOI Creative Commons
Shengnan Wang, Yan‐Chuan Shi,

Shu Lin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116920 - 116920

Published: Aug. 28, 2024

Exposure to Particulate matter 2.5 (PM

Citations

3
Multi-organ toxicity caused by PM2.5 in mice with cardiovascular diseases: The role of PAHs played from the most polluted episodes in China DOI
Jinjin Yu,

Jian Sun,

Yajing Ma

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 375, P. 124330 - 124330

Published: Feb. 1, 2025

Language: Английский

Citations

0
Cardiovascular risk posed by the exposome DOI Creative Commons
Andreas Daiber,

Sanjay Rajagopalan,

Marin Kuntić

et al.

Atherosclerosis, Journal Year: 2025, Volume and Issue: 405, P. 119222 - 119222

Published: May 1, 2025

Chronic non-communicable diseases (NCDs) account for 2/3 of global deaths annually, primarily due to an aging population and external risk factors such as air/water/soil pollution, traffic noise, mental stress, climate change emanating from the environment. These contribute premature loss healthy life years, reflected by disability-adjusted years. The exposome concept was proposed 16 years ago a new research field investigate environment-health associations, also considering underlying pathophysiological pathways. describes lifelong environmental exposures, besides pollutants socioeconomic lifestyle factors, aiming explain associated deaths. can be divided into specific general environment further subcategories organ-specific exposomes well spatially temporally restricted pollutomes. shows considerable interaction with genetic predisposition pre-established chronic diseases, characteristics vulnerable groups. present overview provides background information on impact health disease recent data Global Burden Disease Study. We help selected studies, briefly describe how is measured, discuss biomarkers identified exposomic their development progression atherosclerosis. Major pathways comprise exacerbated stress hormone signaling, oxidative inflammation circadian rhythm dysregulation promoting impairment cardiometabolic function. highlights relevance future preventive medicine, especially concerning cardiovascular therapy.

Language: Английский

Citations

0
Machine learning models for predicting interactions between air pollutants in Tehran Megacity, Iran DOI Creative Commons

Abdullah Kaviani Rad,

Seraj-Odeen Razmi, Mohammad Javad Nematollahi

et al.

Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 104, P. 464 - 479

Published: Aug. 10, 2024

Language: Английский

Citations

3
Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway DOI Creative Commons
Peier Chen, Xiaodong Ning, Weijing Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract The fine particulate matter (PM2.5) in air pollution is a critical risk factor influencing human health. Our study included 8144 participants and showed that the of major adverse cardiovascular events increases by 35% (HR, 1.35; 95% CI, 1.14–1.60) for with highest quartile to PM2.5 exposure as compared those lowest quartile. Bioaerosols, an important environmental PM2.5, can induce systemic chronic inflammation leading vascular aging. Thus, effects bioaerosols are investigated from household garbage stations on aging, underlying mechanisms explored. In vivo, upregulated senescence marker expression levels while causing dysfunction remodeling. vitro, bioaerosol induced decreased proliferation, G0/G1 arrest, impaired migration umbilical vein endothelial cells (HUVECs). Furthermore, single bacterium (AS22a) community was isolated demonstrated it inflammatory factors accelerated cell aging activating NF‐κB/NLRP3 signaling pathway, which may serve primary mechanism PM2.5. These findings suggest high adversely affect

Language: Английский

Citations

2
Aging in Ocular Blood Vessels: Molecular Insights and the Role of Oxidative Stress DOI Creative Commons

Xiuting Cui,

Francesco Buonfiglio, Norbert Pfeiffer

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 817 - 817

Published: April 8, 2024

Acknowledged as a significant pathogenetic driver for numerous diseases, aging has become focal point in addressing the profound changes associated with increasing human life expectancy, posing critical concern global public health. Emerging evidence suggests that factors influencing vascular extend their impact to choroidal and retinal blood vessels. The objective of this work is provide comprehensive overview on ocular vessels related diseases. Additionally, study aims illuminate molecular insights contributing cell aging, particular emphasis choroid retina. Moreover, innovative targets operating within domain are presented discussed.

Language: Английский

Citations

1