Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal? DOI
Dámaris P. Romero‐Rodríguez,

Carlos A. Díaz‐Alvarado,

Héctor Isaac Rocha‐González

et al.

BioFactors, Journal Year: 2025, Volume and Issue: 51(1)

Published: Jan. 1, 2025

Abstract With the increase in elderly population worldwide, number of subjects suffering from tuberculosis (TB) has shown an increased prevalence this group. Immunosenescence is essential phenomenon because it may reactivate lesions and render their adaptive immunity dysfunctional. In addition, inflammation lungs also Although effective drugs are available, they often tolerated inadequately, reducing adherence to therapy leading therapeutic failure. Comorbidities, poor general health status, other medications lead drug adverse reactions reduced treatment elderly. Hence, older adults require individualized approach for better outcomes. Trained immunity, which involves epigenetic reprogramming, contribute balancing dysfunction innate people. This review analyzes relationship between inflammation, age, Mycobacterium . Moreover, we hypothesize that immunomodulation using trained activators will help reduce while enhancing antimicrobial responses Understanding immunomodulation's molecular physiological effects informed decisions about TB prevention strategies uniquely designed

Language: Английский

Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal? DOI
Dámaris P. Romero‐Rodríguez,

Carlos A. Díaz‐Alvarado,

Héctor Isaac Rocha‐González

et al.

BioFactors, Journal Year: 2025, Volume and Issue: 51(1)

Published: Jan. 1, 2025

Abstract With the increase in elderly population worldwide, number of subjects suffering from tuberculosis (TB) has shown an increased prevalence this group. Immunosenescence is essential phenomenon because it may reactivate lesions and render their adaptive immunity dysfunctional. In addition, inflammation lungs also Although effective drugs are available, they often tolerated inadequately, reducing adherence to therapy leading therapeutic failure. Comorbidities, poor general health status, other medications lead drug adverse reactions reduced treatment elderly. Hence, older adults require individualized approach for better outcomes. Trained immunity, which involves epigenetic reprogramming, contribute balancing dysfunction innate people. This review analyzes relationship between inflammation, age, Mycobacterium . Moreover, we hypothesize that immunomodulation using trained activators will help reduce while enhancing antimicrobial responses Understanding immunomodulation's molecular physiological effects informed decisions about TB prevention strategies uniquely designed

Language: Английский

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