Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors DOI Creative Commons

Alexandre Guimarães de Almeida Barros,

Thayana Oliveira Soares,

Ariane Flávia Lage

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 15, 2025

Telomere shortening represents a fundamental mechanism of cellular aging potentially implicated in neurodegenerative processes. This study investigated the complex associations among leukocyte telomere length, cardiovascular risk profiles, and APOE polymorphisms age-related cognitive decline. Through cross-sectional analysis 90 participants stratified by status into three groups: cognitively unimpaired (CU), mild impairment (MCI), Alzheimer’s Disease (AD), we quantified relative length using quantitative PCR, performed genotyping assessed factors. Quantitative revealed significantly reduced AD group compared to CU MCI groups. Multivariate regression identified as an independent predictor ( β = −0.468, p < 0.001). ε4 carrier showed higher prevalence subjects expected. Cardiovascular factors demonstrated no significant correlation with across Our findings establish robust association between advanced AD, suggesting potential utility biomarker. relationship appears traditional factors, highlighting complexity mechanisms neurodegeneration.

Language: Английский

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors DOI Creative Commons

Alexandre Guimarães de Almeida Barros,

Thayana Oliveira Soares,

Ariane Flávia Lage

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 15, 2025

Telomere shortening represents a fundamental mechanism of cellular aging potentially implicated in neurodegenerative processes. This study investigated the complex associations among leukocyte telomere length, cardiovascular risk profiles, and APOE polymorphisms age-related cognitive decline. Through cross-sectional analysis 90 participants stratified by status into three groups: cognitively unimpaired (CU), mild impairment (MCI), Alzheimer’s Disease (AD), we quantified relative length using quantitative PCR, performed genotyping assessed factors. Quantitative revealed significantly reduced AD group compared to CU MCI groups. Multivariate regression identified as an independent predictor ( β = −0.468, p < 0.001). ε4 carrier showed higher prevalence subjects expected. Cardiovascular factors demonstrated no significant correlation with across Our findings establish robust association between advanced AD, suggesting potential utility biomarker. relationship appears traditional factors, highlighting complexity mechanisms neurodegeneration.

Language: Английский

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