Cell Death and Disease,
Journal Year:
2022,
Volume and Issue:
13(10)
Published: Oct. 29, 2022
Reprogramming
lipid
metabolism
is
considered
a
fundamental
step
in
tumourigenesis
that
influences
ferroptosis.
However,
molecular
mechanisms
between
and
ferroptosis
remain
largely
unknown.
Results
from
the
drug
screening
of
464
inhibitors
(for
164
targets)
applied
to
cells
indicated
4
targeted
bromodomain-containing
protein
(BRD4)
significantly
inhibiting
erastin-induced
Functional
studies
proved
loss
BRD4
weakened
oxidative
catabolism
mitochondria,
protecting
excessive
accumulation
peroxides.
Mechanism
research
revealed
transcriptional
levels
fatty
acid
metabolism-related
genes
(HADH,
ACSL1
ACAA2)
participating
β-oxidation
acids
(FAO)
polyunsaturated
(PUFAs)
synthesis
depended
on
activity
super-enhancers
(SEs)
formed
by
HMGB2
their
promoter
regions.
Conclusively,
this
study
demonstrated
was
indispensable
for
based
its
epigenetic
regulatory
affecting
ferroptosis,
providing
new
theoretical
reference
understanding
relationship
deeply.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(3)
Published: March 1, 2025
Colorectal
cancer
(CRC)
ranks
among
the
most
prevalent
malignant
neoplasms
globally.
A
growing
body
of
evidence
underscores
pivotal
roles
genetic
alterations
and
dysregulated
epigenetic
modifications
in
pathogenesis
CRC.
In
recent
years,
reprogramming
tumor
cell
metabolism
has
been
increasingly
acknowledged
as
a
hallmark
cancer.
Substantial
suggests
crosstalk
between
metabolic
modifications,
highlighting
complex
interplay
genome
that
warrants
further
investigation.
Biomarkers
associated
with
characteristics
CRC
hold
significant
clinical
implications.
Nevertheless,
elucidating
genetic,
epigenetic,
landscapes
continues
to
pose
considerable
challenges.
Here,
we
attempt
summarize
key
genes
driving
onset
progression
related
regulators,
clarify
gene
expression
signaling
pathways
regulation,
explore
potential
events
reprogramming,
providing
comprehensive
mechanistic
explanation
for
Finally,
by
integrating
reliable
targets
from
genetics,
epigenetics,
processes
promise
translation
into
practice,
aim
offer
more
strategies
overcome
bottlenecks
treatment.
Cell Death and Disease,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 17, 2025
Abstract
Ovarian
cancer
(OC)
is
often
detected
at
an
advanced
stage
and
has
a
high
recurrence
rate
after
surgery
or
chemotherapy.
Thus,
it
essential
to
develop
new
strategies
for
OC
treatment.
This
study
tended
investigate
the
effects
of
endothelial
cell-specific
molecule
1
(ESM1)
in
OC.
The
impact
ESM1
on
lipid
metabolism
was
investigated
through
regulation
expression.
Differential
genes
regulated
by
were
screened
mRNA
sequencing.
role
autophagy
explored
using
inhibitor
chloroquine
(CQ).
Co-IP,
dual-luciferase
reporter
assay,
actinomycin
D
treatment
others
used
analyze
mechanism
metabolism.
xenograft
mouse
model
constructed
explore
development.
regulatory
patient
samples
verified
microarray
analysis
Log-rank
(Mantel-Cox)
test.
After
silencing,
cholesterol
synthesis
decreased
lipolysis
increased.
sequencing
revealed
that
related
Beclin
(BECN1).
In
vitro
experiments,
inhibited
suppressing
BECN1-mediated
autophagy.
BECN1
expression
transcription
factor
Kruppel-like
10
(KLF10).
competitive
binding
between
HSPA5
promoted
ubiquitination
degradation
HMGCR,
thereby
inhibiting
production.
intervention
experiment
with
exogenous
showed
positive
correlation
m6A
reader
IGF2BP3
content.
Mechanistically,
stability
mRNA.
vivo
modified
methylation
lipolysis.
High
predicted
poor
prognosis
patients.
IGF2BP3/ESM1/KLF10/BECN1
feedback,
which
promising
target
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: Aug. 4, 2021
Lipid
metabolism
is
an
essential
biological
process
involved
in
nutrient
adjustment,
hormone
regulation,
and
lipid
homeostasis.
An
irregular
lifestyle
long-term
overload
can
cause
lipid-related
diseases,
including
atherosclerosis,
myocardial
infarction
(MI),
obesity,
fatty
liver
diseases.
Thus,
novel
tools
for
efficient
diagnosis
treatment
of
dysfunctional
are
urgently
required.
Furthermore,
it
known
that
lncRNAs
based
regulation
like
sponging
microRNAs
(miRNAs)
or
serving
as
a
reservoir
play
role
the
progression
Accordingly,
better
understanding
regulatory
roles
diseases
would
provide
basis
identifying
potential
biomarkers
therapeutic
targets
This
review
highlighted
latest
advances
on
summarised
current
knowledge
dysregulated
their
molecular
mechanisms.
We
have
also
provided
insights
into
underlying
mechanisms
which
might
serve
The
information
presented
here
may
be
useful
designing
future
studies
advancing
investigations
diagnosis,
prognosis,
therapy
Molecular Omics,
Journal Year:
2021,
Volume and Issue:
17(3), P. 464 - 471
Published: Jan. 1, 2021
Metabolic
reprogramming
is
a
hallmark
of
cancer,
which
still
far
from
being
fully
understood
in
colorectal
cancer.
In
order
to
characterize
the
metabolic
changes
we
performed
metabolomics
analysis
paired
colon
tissues
cancer
patients
by
using
liquid
chromatography-mass
spectrometry
(LC-MS)-based
method.
Bioinformation
was
used
define
important
metabolites
and
pathways,
as
well
prognosis
significance
expression
levels
key
molecules.
The
results
indicated
that
metabolite
phenotype
cancerous
obviously
different
their
normal
counterpart,
identified
series
including
decreased
trends
glucose,
citrate,
serotonin,
5-hydroxytryptophol
5-hydroxyindoleacetate,
increased
glutamate,
glutathione,
creatine,
proline,
lactate,
fructose
1,6-bisphosphate,
succinate,
tryptophan,
kynurenine
long
chain
acyl-carnitines.
These
are
mainly
implicated
energy
metabolism,
amino
acid
glutathione
metabolism
fatty
metabolism.
addition,
found
several
molecules
these
pathways
were
closely
correlated
with
patients.
This
study
characterizes
profile
provides
more
insightful
understanding
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(11)
Published: Nov. 23, 2023
Abstract
Lipid
metabolism
is
the
key
to
ferroptosis
susceptibility.
However,
little
known
about
underlying
mechanisms
in
osteosarcoma
cells.
Functional
restriction
of
bromodomain-containing
protein
4
(BRD4)
reduced
susceptibility
erastin-induced
cells
both
vitro
and
vivo.
Mechanically,
BRD4
controls
splicing
efficiency
RNA
precursor
(pre-mACSL3)
ACSL3
(ACSL3)
by
recruiting
serinerich/threonine
kinase
2
(SRPK2)
assemble
catalytic
platform.
Moreover,
AMP-binding
domain
significantly
influences
arachidonic
acid
synthesis
thus
determines
ferroptosis.
Overall,
we
found
a
BRD4-mediated
pre-mACSL3
affecting
Data
this
study
fills
some
gap
understanding
post-transcriptional
regulatory
provides
new
insights
into
lipid
regulation
its
effect
on
