IntechOpen eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 3, 2023
Epilepsy
is
a
neurological
disorder
characterised
by
recurrent
seizures,
which
can
significantly
impact
patient’s
quality
of
life.
While
current
management
strategies
for
epilepsy,
such
as
antiepileptic
drugs
and
surgery,
are
effective
many
patients,
there
need
novel
therapies
that
provide
better
seizure
control
improve
patients’
outcomes.
Oxytocin,
neuropeptide
known
its
role
in
social
bonding
trust,
has
emerged
promising
therapy
epilepsy.
Preclinical
studies
have
shown
oxytocin
reduce
activity
outcomes
animal
models
In
contrast,
clinical
suggested
may
frequency
severity
some
epilepsy
patients.
This
chapter
reviews
the
knowledge
including
potential
mechanisms
oxytocin’s
effects,
limitations
challenges
studies,
future
research
directions
implications.
The
also
discusses
broader
on
understanding
behaviour
disorders.
Overall,
highlights
underscores
further
research.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 6, 2023
Abstract
Cytokines
primarily
interact
with
specific
cytokine
receptors
on
the
cell
surface
as
essential
signal
transduction
pathways
in
many
physiological
and
pathological
processes.
Therapeutic
agents
targeting
cytokine-cytokine
receptor
(CK-CKR)
interactions
lead
to
disruption
cellular
signaling
function
have
been
demonstrated
effective
treatment
of
diseases
including
tumors.
However,
a
lack
universal
quick
access
annotated
structural
regions
CK/CKR
has
limited
progress
structure-driven
approach
development
targeted
macromolecular
drugs
precision
medicine
therapeutics.
Herein
we
develop
CytoSIP
(Single
nucleotide
polymorphisms
(SNPs),
Interface,
P
henotype),
rich
internet
application
based
database
atomic
around
hotspots
experimentally
determined
complexes.
The
content
includes
following
key
features:
(1)
SNPs
CK/CKR;
(2)
involving
at
domain
level,
interfaces,
oligomeric
epitopes,
or
other
drug
surfaces;
(3)
phenotypes
associated
SNPs.
introduces
unique
tri-level
SIP
data
model
link
genetic
variants
(atomic
level)
disease
(organism
using
protein
structure
(complexes)
an
underlying
framework
(molecule
level).
Moreover,
implements
screening
criteria
tools
allow
customized
selection
relevant
subset
for
study
interest.
This
reduces
time
resources
needed
interrogate
large
datasets
allows
rapid
cytokines
proteins
interfaces
design
any
signaling/function
mechanisms
their
correlation
pathologies.
crafted
herein
bridges
genotype
phenotype,
facilitating
not
only
panoramic
investigation
context-dependent
crosstalk
between
but
also
therapeutic
agents.
portal
website
is
publicly
accessible
https://CytoSIP.biocloud.top
.
IntechOpen eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 3, 2023
Epilepsy
is
a
neurological
disorder
characterised
by
recurrent
seizures,
which
can
significantly
impact
patient’s
quality
of
life.
While
current
management
strategies
for
epilepsy,
such
as
antiepileptic
drugs
and
surgery,
are
effective
many
patients,
there
need
novel
therapies
that
provide
better
seizure
control
improve
patients’
outcomes.
Oxytocin,
neuropeptide
known
its
role
in
social
bonding
trust,
has
emerged
promising
therapy
epilepsy.
Preclinical
studies
have
shown
oxytocin
reduce
activity
outcomes
animal
models
In
contrast,
clinical
suggested
may
frequency
severity
some
epilepsy
patients.
This
chapter
reviews
the
knowledge
including
potential
mechanisms
oxytocin’s
effects,
limitations
challenges
studies,
future
research
directions
implications.
The
also
discusses
broader
on
understanding
behaviour
disorders.
Overall,
highlights
underscores
further
research.
