The Bright Future of mRNA as a Therapeutic Molecule

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 376 - 376

Published: March 26, 2025

The rapid success of messenger (m) RNA vaccines against COVID-19 has pushed the mRNA to forefront drug research. promise mRNA-based therapeutics and in other areas is not new but now emerging stronger. We review basic concepts, key historical aspects, recent research on as a therapeutic molecule fight infectious diseases cancer. also show current patent perspective this field. Altogether, we describe that technology rapidly moving field aiming for bright future.

Language: Английский

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Cancer vaccines: Target antigens, vaccine platforms and preclinical models

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 101, P. 101324 - 101324

Published: Dec. 3, 2024

This review provides a comprehensive overview of the evolving landscape cancer vaccines, highlighting their potential to revolutionize tumor prevention. Building on success vaccines against virus-related cancers, such as HPV- and HBV-associated cervical liver current challenge is extend these achievements prevention non-viral tumors treatment preneoplastic or early neoplastic lesions. analyzes critical aspects preventive anti-cancer vaccination, focusing choice target antigens, development effective vaccine platforms technologies, use various model systems for preclinical testing, from laboratory rodents companion animals.

Language: Английский

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Short Peptides as Powerful Arsenal for Smart Fighting Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3254 - 3254

Published: Sept. 24, 2024

Short peptides have been coming around as a strong weapon in the fight against cancer on all fronts—in immuno-, chemo-, and radiotherapy, also combinatorial approaches. Moreover, short relevance imaging or 3D culture. Thanks to natural ‘smart’ nature of peptides, their unique structural features, well recent progress biotechnological bioinformatics development, are playing an enormous role evolving cutting-edge strategies. Self-assembling may create excellent structures stimulate cytotoxic immune responses, which is essential for immunotherapy. can help establish versatile strategies with high biosafety effectiveness. Supramolecular peptide-based vaccines entered clinical trials. Peptide assemblies be platforms delivery antigens, adjuvants, cells, and/or drugs. unappreciated, especially vaccine aspect. Meanwhile, they still hide undiscovered unlimited potential. Here, we provide timely update this highly active fast-evolving field.

Language: Английский

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Vaccination and personalized cancer vaccines focusing on common cancers in women: a narrative review

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 270, P. 155983 - 155983

Published: April 18, 2025

Language: Английский

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Vaccines for cancer prevention and treatment

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 101334 - 101334

Published: Dec. 1, 2024

Language: Английский

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