Impact of hyperglycaemia on cellular microenvironment and function of endometrium and uterine tube: scoping review focused on infertility in diabetic women DOI Creative Commons
Peter Jackuliak, Martin Jankovský,

Magdaléna Kovářová

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: May 23, 2025

Introduction Diabetes mellitus (DM) and associated comorbidities correspond to female infertility by many interrelated mechanisms. Yet most prior research focuses only on ovary dysfunction. Our work evaluates literature mechanisms of DM-induced uterine tube endometrial dysfunction, corresponding impacts fertility, potential evidence-based intervention targets. Methods We conducted a scoping review (mapping review) follows the Joanna Briggs Institute (Manual for Evidence Synthesis, 2020 version). After identifying questions, we comprehensive search across four electronic databases entering keyword “diabetes”, with combination other keywords as uterus, endometrium, uterine/Fallopian tube, embryo implantation. excluded manuscripts that address issue gestational diabetes. Most these studies were in animals. Results There is compelling evidence connecting DM via endometriosis, thyroid susceptibility infectious disease. damages endometrium before pregnancy glucose toxicity, lesions, excessive immune activity, also hinders receptivity embryo–endometrium crosstalk, such through disrupted homeostasis. hypothesize how may affect function cells including changes number types innate acquired immunity, disrupting immunological barrier alterations formation neutrophil extracellular traps or polarization macrophages. Discussion discuss clinical practice terms glycaemic control, lifestyle modifications, medical interventions. For example, there currently substantial from rodent models using metformin increase thickness, stromal blood vessels restoration normal architecture, bariatric surgery recruitment protective cell endometrium. briefly highlight future prospects stem cells, artificial intelligence, new approaches managing DM-associated infertility. Further are necessary optimizing reproductive outcomes.

Language: Английский

Effect of Diabetes Mellitus on Male Reproductive Hormone of Diabetic Patients Attending Urology Unit of Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria DOI Open Access

Simon Uzor,

Mercy Chinedum Ajuka,

Isaac Uzor

et al.

Journal of Diabetes Mellitus, Journal Year: 2025, Volume and Issue: 15(01), P. 59 - 70

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pharmacogenetics of follicle‐stimulating hormone action in the male DOI Creative Commons
Andrea Graziani, Giuseppe Grande,

Raffele Scafa

et al.

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Abstract Male factor infertility (MFI) is involved in half of the cases couple infertility. The follicle‐stimulating hormone (FSH) therapy considered efficient to improve semen parameters and pregnancy rate patients with idiopathic MFI, following lesson learned from hypogonadotropic hypogonadism. However, while hypogonadism FSH therapy, combination human chorionic gonadotropin (hCG), a well‐established treatment, MFI effects are variable unpredictable. should be personalized tailored on characteristics male patient couple. pivotal aspect accurate identification who might benefit such treatment (responders) those not (nonresponders). To date, selection treated based history, physical examination, analysis, hormonal assessment. these cannot adequately identify priori responder patients. Furthermore, management include pharmacological adaptation (dosage duration therapy), as happens during ovarian hyperstimulation assisted reproductive technologies. In fully pharmacogenetic factors must considered. this paper, we describe evidence dealing pharmacogenetics presenting physiological physiopathological basis studies polymorphisms beta‐subunit ( FSHB ) receptor FSHR gene. According so far available, genetic evaluation recommended only for research purposes, since data conclusive even contrasting. derived quite small different endpoints relatively few cases. Better that consider combined effect several gene polymorphisms, together clinical, biochemical, seminal testicular cytology, necessary develop an algorithm predict response treatment.

Language: Английский

Citations

0
The POHaD paradigm: role of the placenta in paternal programming. DOI
Evangelina Capobianco, Irune Pirrone

Placenta, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Impact of type 2 diabetes mellitus on semen quality in Sudanese males: a case-control study DOI
AbdElkarim A. Abdrabo,

Sara Abdelmahmoud Omer,

Walid Ahmed Hamid Eldaif

et al.

Journal of Research in Applied and Basic Medical Sciences, Journal Year: 2025, Volume and Issue: 11(2), P. 147 - 154

Published: April 1, 2025

Language: Английский

Citations

0
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1 DOI Creative Commons
Xiaohui Zhang, Xinyu Tang,

Ting Gao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Impact of hyperglycaemia on cellular microenvironment and function of endometrium and uterine tube: scoping review focused on infertility in diabetic women DOI Creative Commons
Peter Jackuliak, Martin Jankovský,

Magdaléna Kovářová

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: May 23, 2025

Introduction Diabetes mellitus (DM) and associated comorbidities correspond to female infertility by many interrelated mechanisms. Yet most prior research focuses only on ovary dysfunction. Our work evaluates literature mechanisms of DM-induced uterine tube endometrial dysfunction, corresponding impacts fertility, potential evidence-based intervention targets. Methods We conducted a scoping review (mapping review) follows the Joanna Briggs Institute (Manual for Evidence Synthesis, 2020 version). After identifying questions, we comprehensive search across four electronic databases entering keyword “diabetes”, with combination other keywords as uterus, endometrium, uterine/Fallopian tube, embryo implantation. excluded manuscripts that address issue gestational diabetes. Most these studies were in animals. Results There is compelling evidence connecting DM via endometriosis, thyroid susceptibility infectious disease. damages endometrium before pregnancy glucose toxicity, lesions, excessive immune activity, also hinders receptivity embryo–endometrium crosstalk, such through disrupted homeostasis. hypothesize how may affect function cells including changes number types innate acquired immunity, disrupting immunological barrier alterations formation neutrophil extracellular traps or polarization macrophages. Discussion discuss clinical practice terms glycaemic control, lifestyle modifications, medical interventions. For example, there currently substantial from rodent models using metformin increase thickness, stromal blood vessels restoration normal architecture, bariatric surgery recruitment protective cell endometrium. briefly highlight future prospects stem cells, artificial intelligence, new approaches managing DM-associated infertility. Further are necessary optimizing reproductive outcomes.

Language: Английский

Citations

0