Biomimetic Atorvastatin Self-Assembled Nanomedicine Inhibit the Cyclooxygenase-2/prostaglandin E2 Pathway Enhanced Photothermal and Antitumor Immunity

Biomaterials Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Cancer continues to pose remarkable medical challenges worldwide. While current cancer therapies can lead initial clinical improvement, they are often followed by recurrence, metastasis, and drug resistance, underscoring the urgent need for innovative treatment strategies. Atorvastatin calcium (AC), a widely used lipid-lowering anti-inflammation in clinic, has shown antitumor potential. To further improve efficacy, we developed self-assembled AC polydopamine (PDA) nanoparticles whose surface was coated with macrophage membranes (CM) as biomimetic delivery system [AC@PDA@CM (APM)]. APM showed high drug-loading capacity, excellent stability, bioavailability, tumor-targeting ability, ultimately achieving photothermal synergistic immunotherapy. Our findings indicate that efficiently delivers tumor sites while leveraging therapy (PTT) enhance local ablation immune effect. Notably, mitigates immunosuppression triggered PTT through AC, suppressing COX-2/PGE2 pathway evasion signal CD47. Furthermore, notably reduced nonspecific distribution side effects, which is conducive ensuring safety level of medication. This integrated approach boosts therapeutic efficacy highlights potential multifunctional agent therapy, paving way future applications.

Language: Английский

Targeting tumor microenvironment with RGD-functionalized nanoparticles for precision cancer therapy

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217536 - 217536

Published: Feb. 1, 2025

Language: Английский