International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(10), P. 8519 - 8519
Published: May 10, 2023
Bone
defects,
a
common
orthopedic
problem
in
clinical
practice,
are
serious
threat
to
human
health.
As
alternative
materials
autologous
bone
grafts,
synthetic
cell-free
functionalized
scaffolds
have
been
the
focus
of
recent
research
designing
for
tissue
engineering.
Butyryl
chitin
(BC)
is
derivative
(CT)
with
improved
solubility.
It
has
good
biocompatibility,
but
few
studies
investigated
its
use
repair.
In
this
study,
BC
was
successfully
synthesized
degree
substitution
2.1.
films
were
prepared
using
cast
film
method
and
showed
strong
tensile
strength
(47.8
±
4.54
N)
hydrophobicity
(86.4
2.46°),
which
favorable
mineral
deposition.
An
vitro
cytological
assay
confirmed
excellent
cell
attachment
cytocompatibility
film;
meanwhile,
vivo
degradation
indicated
biocompatibility
BC.
Hydroxyapatite
(HA),
extracted
from
bovine
cancellous
bone,
had
osteogenic
induction
activity
mouse
osteoblast
line
MC3T3-E1.
With
aim
combining
advantages
HA,
BC-HA
composite
scaffold,
pore
structure
mechanical
strength,
by
physical
mixing.
Administered
into
skull
defects
rats,
perfect
bone-binding
performance
effective
structural
support,
significantly
promoted
regeneration
new
bone.
These
results
prove
that
porous
scaffold
successful
engineering
potential
be
further
developed
as
substitute
transplantation.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2024,
Volume and Issue:
35(6), P. 916 - 965
Published: Feb. 13, 2024
In
tissue
engineering
and
regenerative
medicine
applications,
the
utilization
of
bioactive
materials
has
become
a
routine
tool.
The
goal
is
to
create
new
organs
tissues
by
combining
cell
biology,
science,
reactor
engineering,
clinical
research.
As
part
growth
pattern
for
primary
cells
in
an
organ,
backing
material
frequently
used
as
supporting
material.
A
porous
three-dimensional
(3D)
scaffold
can
provide
with
optimal
conditions
proliferating,
migrating,
differentiating,
functioning
framework.
Optimizing
scaffolds'
structure
altering
their
surface
may
improve
adhesion
proliferation.
keratin-based
biomaterials
platform
been
developed
result
discoveries
made
over
past
century
extraction,
purification,
characterization
keratin
proteins
from
hair
wool
fibers.
Biocompatibility,
biodegradability,
intrinsic
biological
activity,
cellular
binding
motifs
make
attractive
biomaterial
scaffolds.
Scaffolds
have
extracted
because
capacity
self-assemble
polymerize
into
intricate
3D
structures.
this
review
article,
applications
scaffolds
different
including
bone,
skin,
nerve,
vascular
are
explained
based
on
common
methods
fabrication
such
electrospinning,
freeze-drying
process,
sponge
replication
method.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(5), P. 3259 - 3272
Published: Jan. 1, 2025
Optimizing
solvent
systems
for
electrospun
PLGA
tissue
scaffolds
enables
control
over
mechanical
properties.
Hansen
solubility
theory
helps
identify
key
effects,
enabling
the
design
of
tunable,
high-performance
biomedical
use.
Roughly
1.71
billion
people
worldwide
suffer
from
large
bone
abnormalities,
which
are
the
primary
cause
of
disability.
Traditional
grafting
procedures
have
several
drawbacks
that
impair
their
therapeutic
efficacy
and
restrict
use
in
clinical
settings.
A
great
deal
work
has
been
done
to
create
fresh,
more
potent
strategies.
Under
these
circumstances,
a
crucial
technique
for
regeneration
major
lesions
emerged:
tissue
engineering
(BTE).
BTE
involves
biomaterials
can
imitate
natural
design
bone.
To
yet,
no
biological
material
able
fully
meet
parameters
perfect
implantable
material,
even
though
varieties
created
investigated
regeneration.
Against
this
backdrop,
researchers
focused
interest
over
past
few
years
on
subject
nanotechnology
nanostructures
regenerative
medicine.
The
ability
nanoengineered
particles
overcome
current
constraints
strategies─such
as
decreased
cell
proliferation
differentiation,
insufficient
mechanical
strength
materials,
production
extrinsic
factors
required
effective
osteogenesis
revolutionized
field
engineering.
effects
nanoparticles
characteristics
application
materials
main
topics
our
review,
summarizes
most
recent
vitro
vivo
research
context
BTE.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 052005 - 052005
Published: Aug. 6, 2024
Abstract
Bone
is
a
dynamic
tissue
that
can
always
regenerate
itself
through
remodeling
to
maintain
biofunctionality.
This
performs
several
vital
physiological
functions.
However,
bone
scaffolds
are
required
for
critical-size
damages
and
fractures,
these
be
addressed
by
engineering.
engineering
(BTE)
has
the
potential
develop
repairing
damaged
bone.
BTE
multidisciplinary
engineered
scaffold
with
desired
properties
tissue.
Herein,
we
have
provided
an
overview
of
common
carbohydrate
polymers,
fundamental
structural,
physicochemical,
biological
properties,
fabrication
techniques
We
also
discussed
advanced
biofabrication
strategies
limitations
prospects
highlighting
significant
issues
in
There
review
articles
available
on
state-of-the-art
article
recent
progress
trends
within
last
3–5
years
emphasizing
challenges
future
perspectives.
