ACS Applied Energy Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Solar
absorbers
play
a
crucial
role
in
interfacial
solar
steam
generation
(ISSG)
technology,
facilitating
efficient
and
sterilization.
Nonetheless,
limitations
conversion
efficiency
water
transport
effects,
coupled
with
challenges
outdoor
portability
of
traditional
installations,
have
hindered
the
progress
sterilization
technology.
In
this
work,
based
on
Cu8S5/PDA
nanoparticles
(NPs)
sodium
alginate
(SA)
hydrogel,
absorber
superior
photothermal
antibacterial
properties
was
developed.
The
Cu8S5/PDA@SA
hydrogel
synthesized
via
situ
deposition
demonstrated
remarkable
full-spectrum
absorption
performance
stable
ability
(37.56%),
capable
effectively
destroying
bacterial
structure
metabolic
functions
through
multiple
therapeutic
mechanisms:
therapy
thermal
effect
high
temperature
chemodynamic
photodynamic
therapies
oxidation
reactive
oxygen
species
depletion
intracellular
glutathione,
achieving
100%
presenting
excellent
potential
under
low
irradiation
conditions.
This
study
proposes
promising
avenue
for
development
environmentally
friendly
easy-to-use
sterilizers
off-grid
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(16), P. 15962 - 15977
Published: Aug. 3, 2023
Treatment
of
diabetic
foot
ulcers
(DFU)
needs
to
reduce
inflammation,
relieve
hypoxia,
lower
blood
glucose,
promote
angiogenesis,
and
eliminate
pathogenic
bacteria,
but
the
therapeutic
efficacy
is
greatly
limited
by
diversity
synergy
drug
functions
as
well
DFU
microenvironment
itself.
Herein,
an
ultrasound-augmented
multienzyme-like
nanozyme
hydrogel
spray
was
developed
using
hyaluronic
acid
encapsulated
l-arginine
ultrasmall
gold
nanoparticles
Cu1.6O
coloaded
phosphorus
doped
graphitic
carbon
nitride
nanosheets
(ACPCAH).
This
possesses
five
types
enzyme-like
activities,
including
superoxide
dismutase
(SOD)-,
catalase
(CAT)-,
glucose
oxidase
(GOx)-,
peroxidase
(POD)-,
nitric
oxide
synthase
(NOS)-like
activities.
The
kinetics
reaction
mechanism
sonodynamic/sonothermal
synergistic
enhancement
SOD-CAT-GOx-POD/NOS
cascade
ACPCAH
are
fully
investigated.
Both
in
vitro
vivo
tests
demonstrate
that
this
can
be
activated
thus
accelerating
wound
healing
effectively.
study
highlights
a
competitive
approach
based
on
nanozymes
for
development
all-in-one
therapies.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 7, 2024
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(33)
Published: June 14, 2024
Infectious
diseases
caused
by
bacterial,
viral,
and
fungal
pathogens
present
significant
global
health
challenges.
The
rapid
emergence
of
antimicrobial
resistance
exacerbates
this
issue,
leading
to
a
scenario
where
effective
antibiotics
are
increasingly
scarce.
Traditional
antibiotic
development
strategies
proving
inadequate
against
the
swift
evolution
microbial
resistance.
Therefore,
there
is
an
urgent
need
develop
novel
with
mechanisms
distinct
from
those
existing
antibiotics.
Nanozybiotics,
which
nanozyme-based
antimicrobials,
mimic
catalytic
action
lysosomal
enzymes
in
innate
immune
cells
kill
infectious
pathogens.
This
review
reinforces
concept
nanozymes
provides
comprehensive
summary
recent
research
advancements
on
potential
candidates.
Initially,
nanozybiotics
categorized
based
their
activities,
mimicking
either
oxidoreductase-like
or
hydrolase-like
functions,
thereby
highlighting
superior
combating
then
discusses
progress
treating
infections,
confirming
as
translational
nanozybiotic-based
products,
including
hydrogels,
nanorobots,
sprays,
bandages,
masks,
protective
clothing,
also
considered.
Finally,
current
challenges
future
prospects
nanozybiotic-related
products
explored,
emphasizing
design
capabilities
for
applications.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Biofilms
play
a
pivotal
role
in
bacterial
pathogenicity
and
antibiotic
resistance,
representing
major
challenge
the
treatment
of
infections.
The
limited
diffusion
inactivation
efficacy
antibiotics
within
biofilms
hinder
their
clearance,
while
increasing
dosage
may
enhance
effectiveness,
it
also
promotes
resistance.
Nano-delivery
systems
that
target
antimicrobial
agents
directly
to
offer
promising
strategy
overcome
this
challenge.
This
review
summarizes
resistance
mechanisms
therapeutic
challenges
associated
with
biofilms,
focus
on
recent
advances
nano-delivery
such
as
liposomes,
nanoemulsions,
cell
membrane
vesicles
(CMVs),
polymers,
dendrimers,
nanogels,
inorganic
nanoparticles,
metal-organic
frameworks
(MOFs).
Furthermore,
explores
potential
applications
biofilm
provides
recommendations
guide
future
research
development
field.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
233, P. 112252 - 112252
Published: Aug. 18, 2023
Various
wounds
caused
by
burns,
trauma,
surgery,
and
genetic
irregularities,
including
acute
chronic
wounds,
pose
a
huge
burden
on
global
healthcare.
Many
therapeutic
strategies,
such
as
nanomedicine
regenerative
medicine,
have
been
applied
to
wound
repair
skin
regeneration.
As
promising
exciting
nanomaterial,
metal-organic
frameworks
(MOFs)
encompass
many
desirable
properties,
crystalline
porous
structure,
tunable
size,
good
mechanical
stability,
large
specific
surface
area,
exceptional
chemical
stability.
Most
importantly,
the
performance
of
MOFs
can
be
modulated
changing
synthesis
steps
conditions.
release
metal
ions
modulate
cellular
behaviors
kill
various
microorganisms,
which
meets
this
dual
agent
strategy
for
healing
Additionally,
act
carriers
delivering
bioactive
agents
in
desired
manner.
Recently,
an
increasing
number
researchers
conducted
studies
applying
Based
this,
we
perform
study
report
current
status
further
perspective
MOFs-based
strategy.
Furthermore,
molecular
process
fabrication
were
also
discussed.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11439 - 11439
Published: July 14, 2023
Management
of
chronic
inflammation
and
wounds
has
always
been
a
key
issue
in
the
pharmaceutical
healthcare
sectors.
Curcumin
(CCM)
is
an
active
ingredient
extracted
from
turmeric
rhizomes
with
antioxidant,
anti-inflammatory,
antibacterial
activities,
thus
showing
significant
effectiveness
toward
wound
healing.
However,
its
shortcomings,
such
as
poor
water
solubility,
chemical
stability,
fast
metabolic
rate,
limit
bioavailability
long-term
use.
In
this
context,
hydrogels
appear
to
be
versatile
matrix
for
carrying
stabilizing
drugs
due
their
biomimetic
structure,
soft
porous
microarchitecture,
favorable
biomechanical
properties.
The
drug
loading/releasing
efficiencies
can
also
controlled
via
using
highly
crystalline
metal-organic
frameworks
(MOFs).
Herein,
flexible
hydrogel
composed
sodium
alginate
(SA)
CCM-loaded
MOFs
was
constructed
release
activity.
morphology
physicochemical
properties
composite
were
analyzed
by
scanning
electron
microscopy
(SEM),
Fourier
transform
infrared
spectroscopy
(FT-IR),
X-ray
diffraction
(XRD),
ultraviolet-visible
(UV-Vis),
Raman
spectroscopy,
mechanical
property
tests.
results
showed
that
twistable
bendable
comply
human
skin
mechanically.
as-prepared
could
capture
efficient
CCM
slow
effectively
kill
bacteria.
Therefore,
expected
provide
new
management
system
dressings.
