Fabrication of 3D printed Si3N4 bioceramics with superior comprehensive performance through ZnO nanowires doping DOI Creative Commons
Xiaofeng Zeng, Coswald Stephen Sipaut, Noor Maizura Ismail

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(18), P. 34457 - 34466

Published: June 13, 2024

Silicon nitride (Si3N4) material holds significant potential as a widespread applied biomedical with high reliability in mechanical properties and biological activity. This study utilized 3D printing techniques to fabricate Si3N4 bioceramics reinforced zinc oxide (ZnO) nanowires, which overcomes the dilemma faced by traditional materials, possess excellent but lack sufficient antibacterial performance, or porous materials that exhibit good yet suffer from poor characteristics. Compared Ti-alloy, Al2O3, PEEK, conventional bioceramic an addition of 5 wt percent (wt%) ZnO nanowires retains superior properties: bending strength 735 MPa, fracture toughness 8.25 MPa m1/2, vickers hardness 14.8 GPa, compressive 2575 MPa. Furthermore, demonstrates commendable biocompatibility outstanding effects. Cellular activity on surface this is also noted be exceptionally vigorous. Research indicates synergistic effects characteristics appropriate inclusion positively interact β-Si3N4 crystals, are primarily responsible for exceptional comprehensive performance printed bioceramics.

Language: Английский

Optimizing environmental sustainability in pharmaceutical 3D printing through machine learning DOI Creative Commons
Hanxiang Li,

Manal E. Alkahtani,

Abdul W. Basit

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 648, P. 123561 - 123561

Published: Oct. 30, 2023

3D Printing (3DP) of pharmaceuticals could drastically transform the manufacturing medicines and facilitate widespread availability personalised healthcare. However, with increasing awareness environmental damage manufacturing, 3DP must be eco-friendly, especially when it comes to carbon emissions. This study investigated effects pharmaceutical 3DP. Using Design Experiments (DoE) Machine Learning (ML), we looked at energy use in Fused Deposition Modeling (FDM). From 136 experimental runs across four common dosage forms, identified several key parameters that contributed consumption, consequently CO

Language: Английский

Citations

12
3D printing technology and its combination with nanotechnology in bone tissue engineering DOI
Yuezhou Wu, Yucheng Ji, Zhuocheng Lyu

et al.

Biomedical Engineering Letters, Journal Year: 2024, Volume and Issue: 14(3), P. 451 - 464

Published: Jan. 30, 2024

Language: Английский

Citations

5
Three-Dimensional Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering DOI Creative Commons
Zeeshan Sheikh, Vasudev Vivekanand Nayak,

Umer Daood

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(3), P. 60 - 60

Published: March 1, 2024

Three-dimensional printing (3DP) technology has revolutionized the field of use bioceramics for maxillofacial and periodontal applications, offering unprecedented control over shape, size, structure bioceramic implants. In addition, have become attractive materials these applications due to their biocompatibility, biostability, favorable mechanical properties. However, despite advantages, implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, an increased risk implant failure. To address challenges, researchers been developing strategies improve 3D-printed The purpose this review is provide overview 3DP techniques designed bone regeneration. also addresses incorporation active biomolecules in constructs stimulate By controlling surface roughness chemical composition implant, construct can be tailored promote osseointegration reduce adverse reactions. Additionally, growth factors, morphogenic proteins (rhBMP-2) pharmacologic agent (dipyridamole), incorporated new tissue. Incorporating porosity into formation overall response implant. As such, employing modification, combining other materials, incorporating workflow lead better patient healing outcomes.

Language: Английский

Citations

4
Experimental investigation of PCL‐based composite material fabricated using solvent‐cast 3D printing process DOI
Debashish Gogoi,

Tanyu Donarld Kongnyui,

Manjesh Kumar

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(5)

Published: May 1, 2024

Abstract Bone tissue engineering relies on scaffolds with enhanced mechanical properties, achievable through 3D printing techniques. Our study focuses enhancing properties using a solvent‐cast method. For this, poly‐ε‐caprolactone (PCL) reinforced polyhydroxybutyrate (PHB), and synthetic fluorapatite (FHAp) nanopowders were utilized, immersed in solution of dichloromethane (DCM) dimethylformamide (DMF). Sol–gel method was used to synthesized FHAp, the XRD pattern confirmed crystalline FHAp presence, notable peaks at 2 θ values 31.937°, 33.128°, 32.268°, 25.864°. Moreover, composites exhibited nonchemical PCL‐PHB/FHAp interactions, PHB crystallographic planes evident. Surface roughness, assessed via RMS values, showed progressive increases higher content. Tensile strength peaked 19% wt/v PHB, varied effects FHAp. Compressive reached its apex 30% content consistently strength. Flexural notably increased peaking wt/v, further Young's modulus rose both Hardness Cell viability improved showing responses Hemocompatibility evaluations indicated low hemolysis percentages, especially balanced PHB/FHAp compositions. These findings highlight crucial role composite compositions tailoring biological for optimal bone scaffold design, promising advancements regeneration technologies.

Language: Английский

Citations

4
Fabrication of 3D printed Si3N4 bioceramics with superior comprehensive performance through ZnO nanowires doping DOI Creative Commons
Xiaofeng Zeng, Coswald Stephen Sipaut, Noor Maizura Ismail

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(18), P. 34457 - 34466

Published: June 13, 2024

Silicon nitride (Si3N4) material holds significant potential as a widespread applied biomedical with high reliability in mechanical properties and biological activity. This study utilized 3D printing techniques to fabricate Si3N4 bioceramics reinforced zinc oxide (ZnO) nanowires, which overcomes the dilemma faced by traditional materials, possess excellent but lack sufficient antibacterial performance, or porous materials that exhibit good yet suffer from poor characteristics. Compared Ti-alloy, Al2O3, PEEK, conventional bioceramic an addition of 5 wt percent (wt%) ZnO nanowires retains superior properties: bending strength 735 MPa, fracture toughness 8.25 MPa m1/2, vickers hardness 14.8 GPa, compressive 2575 MPa. Furthermore, demonstrates commendable biocompatibility outstanding effects. Cellular activity on surface this is also noted be exceptionally vigorous. Research indicates synergistic effects characteristics appropriate inclusion positively interact β-Si3N4 crystals, are primarily responsible for exceptional comprehensive performance printed bioceramics.

Language: Английский

Citations

4