Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 27, 2024
Calcium
phosphate
(CaP)
biomaterials
are
amongst
the
most
widely
used
synthetic
bone
graft
substitutes,
owing
to
their
chemical
similarities
mineral
part
of
matrix
and
off-the-shelf
availability.
However,
ability
regenerate
in
critical-sized
defects
has
remained
inferior
gold
standard
autologous
bone.
Hence,
there
is
a
need
for
methods
that
can
be
employed
efficiently
produce
CaPs
with
different
properties,
enabling
screening
consequent
fine-tuning
properties
towards
effective
regeneration.
To
this
end,
we
propose
use
droplet
microfluidics
rapid
production
variety
CaP
microparticles.
Particularly,
study
aims
optimize
steps
microfluidic-based
process,
including
generation,
in-droplet
synthesis,
purification
sintering,
order
obtain
library
microparticles
fine-tuned
properties.
The
results
showed
size-controlled,
monodisperse
water-in-oil
microdroplets
containing
calcium-
phosphate-rich
solutions
produced
using
flow-focusing
droplet-generator
microfluidic
chip.
We
optimized
synthesis
protocols
based
on
mineralization
range
without
inorganic
additives.
This
was
achieved
by
adjusting
parameters,
such
as
precursor
concentration,
pH
value,
aging
time,
applying
heat
treatment.
In
addition,
our
indicated
fabrication
parameters
method
alter
microstructure
degradation
behavior
CaPs.
Overall,
highlight
potential
platform
engineering
microparticle
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
Abstract
The
number
of
people
with
hearing
loss
disorders
is
enormous,
causing
great
physical
and
mental
stress
to
patients,
as
well
a
huge
social
burden.
Among
these
caused
by
inner
ear
lesions
accounts
for
large
proportion.
Therefore,
treatment
the
important.
Inner
drug
delivery
systems,
which
can
reduce
side
effects
systemic
administration
delivering
drugs
directly
ear,
are
important
in
sensorineural
loss.
Here,
development
systems
focused,
including
complex
physiological
structure
that
they
face,
types
delivered,
routes
administration,
forms
carrier
platforms.
Recent
studies
this
process
presented
it
concluded
summary
outlook
on
problems
faced
possible
solutions.
Abstract
Drug
therapies
are
the
cornerstone
of
systemic
treatment
for
pancreatic
cancer
patients.
However,
relative
outcome
drug
evaluation
is
often
hampered
by
complex
microenvironment
due
to
lack
reasonable
tumor
models.
Here,
we
proposed
a
novel
platform
that
integrated
adenocarcinoma
cells
encapsulated
into
hydrogel
microcapsules
three‐dimensional
(3D)
cultivation
and
antitumor
agent
evaluation.
These
contain
alginate/poly
(
N
‐isopropyl
acrylamide)
(alginate/PNIPAM)
shells
carboxymethyl
cellulose
cores,
which
generated
through
microfluidic
electrospray
technique.
The
have
feature
rapid
response
temperature,
they
can
regulate
internal
pressure
environment.
Besides,
benefiting
from
good
monodispersity,
precise
size
control,
biocompatibility
these
microcapsules,
wrapped
capacity
proliferating
spontaneously
forming
3D
spheroids
with
cell
viability.
We
demonstrated
in
composite
different
PNIPAM
concentrations
showed
sensitivity,
could
be
ascribed
influence
external
pressures
results
indicate
coated
responsive
great
potential
analysis
sensitivity.
Aggregate,
Journal Year:
2023,
Volume and Issue:
5(2)
Published: Nov. 22, 2023
Abstract
Colloidal
crystals
are
materials
self‐assembled
from
the
colloidal
nanoparticles.
Due
to
ordered
microstructure,
they
exhibit
significant
optical
properties
and
have
shown
huge
potential
in
field
of
biosensing.
Besides,
unique
macroscopic
shapes
can
also
play
a
critical
role
sensing
process.
Here,
we
present
comprehensive
discussion
on
crystal‐based
biosensors
with
different
topological
shapes,
including
development
strategies
currently
reported
crystal
particles,
films,
fibers,
their
recent
progress
In
addition,
faced
challenges
possible
solutions
concluded
discussed.
We
expect
this
review
enrich
knowledge
encourage
communication
interdisciplinary
researchers,
thus
promoting
further
practical
applications
biosensors.
