A PDMS diaphragm-based bioreactor integrating mechanical and electrical stimulation for enhanced cardiomyocyte functionality and maturation

Sensors and Actuators A Physical, Journal Year: 2025, Volume and Issue: unknown, P. 116468 - 116468

Published: March 1, 2025

Language: Английский

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Advances and Challenges in 3D Bioprinted Cancer Models: Opportunities for Personalized Medicine and Tissue Engineering

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 948 - 948

Published: March 31, 2025

Cancer is the second leading cause of death worldwide, after cardiovascular disease, claiming not only a staggering number lives but also causing considerable health and economic devastation, particularly in less-developed countries. Therapeutic interventions are impeded by differences patient-to-patient responses to anti-cancer drugs. A personalized medicine approach crucial for treating specific patient groups includes using molecular genetic screens find appropriate stratifications patients who will respond (and those not) treatment regimens. However, information on which risk stratification method can be used hone cancer types likely responders agent remains elusive most cancers. Novel developments 3D bioprinting technology have been widely applied recreate relevant bioengineered tumor organotypic structures capable mimicking human tissue microenvironment or adequate drug high-throughput screening settings. Parts autogenously printed form tissues computer-aided design concept where multiple layers include different cell compatible biomaterials build configurations. Patient-derived stromal cells, together with material, extracellular matrix proteins, growth factors, create bioprinted models that provide possible platform new therapies advance. Both natural synthetic biopolymers encourage cells biological materials models/implants. These may facilitate physiologically cell-cell cell-matrix interactions heterogeneity resembling real tumors.

Language: Английский

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Gelatin methacrylate/poly(2-ethyl-2-oxazoline) porous hydrogel loaded with kartogenin drug as a biocompatible scaffold for cartilage tissue regeneration

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 404, P. 124982 - 124982

Published: May 10, 2024

Language: Английский

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Advanced strategies in 3D bioprinting for vascular tissue engineering and disease modelling using smart bioinks

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 30, 2024

Advanced three-dimensional (3D) bioprinting technology enables the precise production of complex vascular structures and biomimetic models, driving advancements in tissue engineering disease mechanism research. At core this is smart bioink, which suitable for fabricating models that can be vascularised to meet property requirements various tissues. Examples bioinks include decellularized extracellular matrix (dECM), photocrosslinkable, reversible, microgel-based biphasic (MB) bioinks, whose mechanical properties tuned through external stimuli. This tuning helps generate high-resolution complex-shaped networks essential cell survival functional maturation. review explores advanced 3D strategies using spatially controlled perfusable vitro emphasising reconstruction within bioprinted models. It also discusses challenges future prospects, suggesting could serve as alternatives traditional animal modelling drug screening.

Language: Английский

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Hybrid 3D microfluidic bioprinting for the engineering of cancer models and tissue substitutes

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 4, 2024

3D bioprinting is at the forefront of tissue engineering to fabricate complex constructs resembling functional tissues. However, inability produce heterogeneous tissues and lack spatio-temporal control over release bioactive factors are greatly limiting clinical translation. Herein, combination with high-throughput dispensing using a custom microfluidic system nanoclay-based inks presented. This approach was found enhance printability, retention, controlled factors. Advanced models were developed resemble cancer skeletal tissue, while studying effect anti-cancer (Doxorubicin) pro-osteogenic growth (bone morphogenetic protein-2, BMP-2), respectively. The new nanoclay ink allowed sustained release, making it suitable for long-term applications. These findings suggest that by combining delivery platform can be assembled, offering significant advancements in regenerative medicine.

Language: Английский

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Nature’s Blueprints: Biomimicry and the Evolution of Sustainable Materials

Published: Jan. 1, 2025

Language: Английский

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Forthcoming perspective could revolutionize healthcare worldwide for patients with extensive burns

Journal of Stem Cell Research & Therapeutics, Journal Year: 2025, Volume and Issue: 10(1), P. 17 - 19

Published: Jan. 1, 2025

Burns impact millions of individuals, both adults and children, across the globe, leading to significant morbidity mortality rates. The primary factor influencing survival in burn cases is speed wound healing. Extensive wounds surpass body's natural healing abilities, existing coverage materials often fall short due limitations cellular content, availability, or risk immunological rejection. Severe burns, particularly those that cover a substantial area body, continue pose challenge for contemporary medical practice. Current therapeutic approaches primarily involve skin grafting, which utilizes patient's own healthy tissue facilitate coverage. In situations where affected by burns extensive, it becomes nearly unfeasible locate sufficient grafting. This further exacerbated presence scarring, persistent pain, various other complications considerably diminish quality life who survive. Within this framework, groundbreaking approach utilizing 3D bioprinting (3DBP) stem cell cultivation may offer viable solution addressing severe injuries.

Language: Английский

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Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting

Regenesis repair rehabilitation., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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The rise of 3D bioprinting: from organs to personalized medicine

Patient-Oriented Medicine and Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Bioprinting has emerged as a groundbreaking technology in the realms of organ transplantation and regenerative medicine, addressing critical challenges such shortages tissue repair. This review explores technological advancements innovations bioprinting, highlighting state-of-the-art techniques, bioinks, applications engineering. Key milestones printing functional tissues, including vascularized transplantable prototypes, are discussed alongside role bioprinting personalized where patient-oriented models revolutionizing drug testing therapeutic strategies. Furthermore, this article examines ethical considerations associated with offering insights into its future potential to transform global healthcare.

Language: Английский

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Bone Regeneration: A Review of Current Treatment Strategies

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1838 - 1838

Published: March 8, 2025

Bone regeneration has emerged as a critical research and clinical advancement field, fueled by the growing demand for effective treatments in orthopedics oncology. Over past two decades, significant progress biomaterials surgical techniques led to development of novel solutions treating bone defects, surpassing use traditional autologous grafts. This review aims assess latest approaches regeneration, including autologous, allogenic, xenogenic grafts, naturally derived biomaterials, innovative synthetic substitutes such bioceramics, bioactive glasses, metals, polymers, composite materials, other specialized applications. A comprehensive literature search was conducted on PubMed, focusing studies published between 2019 2024, meta-analyses, reviews, systematic reviews. The evaluated range strategies, examining outcomes, materials used, techniques, effectiveness various defects. identified numerous studies, with inclusion criteria focused those exploring strategies. These provided valuable insights into biological outcomes different graft types. Results indicated that while advancements show promising potential, challenges remain optimizing therapeutic strategies across diverse patient populations settings. findings emphasize need an integrated approach combines scientific research, practice, technological innovation improve therapies. Further is required establish standardized protocols determine optimal application enhance quality care.

Language: Английский

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