ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
Polymer Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Language: Английский
Citations
10
Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 012005 - 012005
Published: Nov. 8, 2024
Abstract Artificial bone graft stands out for avoiding limited source of autograft as well susceptibility to infection allograft, which makes it a current research hotspot in the field defect repair. However, traditional design and manufacturing method cannot fabricate scaffold that mimics complicated bone-like shape with interconnected porous structure multiple properties akin human natural bone. Additive manufacturing, can achieve implant’s tailored external contour controllable fabrication internal microporous structure, is able form almost any designed via layer-by-layer process. As additive promising building artificial scaffold, only combining excellent structural appropriate process produce ideal biological mechanical properties. In this article, we sum up analyze state art methods realize shape/properties collaborative intelligent manufacturing. Scaffold be mainly classified into based on unit cells whole while basic 3D bioprinting are recommended suitable fabrication. The challenges future perspectives manufactured also discussed.
Language: Английский
Citations
9
Biofabrication, Journal Year: 2024, Volume and Issue: 16(4), P. 045014 - 045014
Published: July 15, 2024
Abstract 3D (Bio)printing is a highly effective method for fabricating tissue engineering scaffolds, renowned their exceptional precision and control. Artificial intelligence (AI) has become crucial technology in this field, capable of learning replicating complex patterns that surpass human capabilities. However, the integration AI often hampered by lack comprehensive reliable data. This study addresses these challenges providing one most extensive datasets on 3D-printed scaffolds. It provides open-source dataset employs various techniques, from unsupervised to supervised learning. includes detailed information 1171 featuring variety biomaterials concentrations—including 60 such as natural synthesized biomaterials, crosslinkers, enzymes, etc.—along with 49 cell lines, densities, different printing conditions. We used over 40 machine deep algorithms, tuning hyperparameters reveal hidden predict response, printability, scaffold quality. The clustering analysis using KMeans identified five distinct ones. In classification tasks, algorithms XGBoost, Gradient Boosting, Extra Trees Classifier, Random Forest LightGBM demonstrated superior performance, achieving higher accuracy F1 scores. A fully connected neural network six layers scratch was developed, precisely its accurate predictions. developed associated code are publicly available https://github.com/saeedrafieyan/MLATE promote future research.
Language: Английский
Citations
8
Biomimetics, Journal Year: 2024, Volume and Issue: 9(8), P. 480 - 480
Published: Aug. 9, 2024
The periodontal tissue is made up of supporting tissues and among its functions, it promotes viscoelastic properties, proprioceptive sensors, dental anchorage. Its progressive destruction by disease leads to the loss bone ligaments. For this reason, biomaterials are constantly being developed restore function. Various techniques used promote regenerative dentistry, including 3D bioprinting with bioink formulations. This paper aims review different types formulations in regeneration. Different have been formulated, addition materials into bioinks has conducted, intention improving process creating a that supports cell viability, proliferation, differentiation, stability for
Language: Английский
Citations
5
Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)
Published: July 22, 2024
Achieving efficient scaffolds for bone tissue engineering (TE) requires smartly defined parameters reaching a balance between physical–chemical properties, biocompatibility and complex architectures. Three-dimensional (3D) printing offers precise geometry control of the desired scaffold at micro-scale. However, performance 3D is highly dependent on formulation, challenge being to achieve suitable ink establish most parameters. Gelatin methacryloyl (GelMA) emerges as promising due superior biological photocrosslinking ability printability. The present review focuses evolution GelMA-based inks bioinks from simplest advanced multicomponent formulations capable regeneration. Additionally, comparative analysis different photoinitiators covered, indicating each one's advantages disadvantages. Furthermore, main bioprinting methods that are used in GelMA outlined with required their influence final product performance.
Language: Английский
Citations
4
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113718 - 113718
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: March 12, 2025
Introduction Skin aging is an inevitable physiological process driven by factors like cellular senescence, ultraviolet radiation (UV) radiation, and environmental pollutants. A key feature the accelerated collagen degradation in dermal extracellular matrix, leading to visible signs such as sagging, wrinkles, hyperpigmentation. Traditional fillers, hyaluronic acid collagen-based offer only temporary volume enhancement without stimulating regeneration. Studies have shown that electrical signals generated piezoelectric materials can promote tissue Methods This study explored potential of PHBHHx microspheres innovative skin filler for enhancing regeneration improving maxillofacial aesthetics, with aid low-intensity pulsed ultrasound (LIPUS) stimulation. comprehensive characterizations were conducted, their stimulate was assessed using a subcutaneous injection model New Zealand white rabbits. Results The results indicated exhibited stable properties, great properties excellent biocompatibility. Moreover, when stimulated LIPUS, collagen-regenerating effect further enhanced, histological analysis revealed denser more organized structures LIPUS-stimulated group. Discussion These findings highlight advanced biomaterial applications aesthetic medicine, particularly promoting rejuvenation.
Language: Английский
Citations
0
Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00407 - e00407
Published: March 1, 2025
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3510 - 3510
Published: April 9, 2025
Recent advancements in 3D bioprinting technology have transformed the development of complex tissue scaffolds, offering significant potential for applications bone and dental regenerative medicine. Oil-based hydrogels garnered considerable interest owing to their tunable mechanical properties, biocompatibility, ability facilitate cell adhesion, proliferation, differentiation. This review provides an in-depth recent research regarding utilization oil-based development, focusing on strategies. The investigates biological efficacy diverse oils used hydrogel formulations, as well physicochemical promoting osteogenesis regeneration. Significant results from both vitro vivo are examined, emphasizing capacity sustain functions promote Challenges such stability, printability, cytotoxicity efficiency thoroughly along with strategies improve these materials translational clinical applications. study highlights revolutionary enhancing medicine, providing insights into current status, future pathways.
Language: Английский
Citations
0