Published: Jan. 1, 2024
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract The interaction between biomaterials and immune system is a critical area of research, especially in tissue engineering regenerative medicine. A fascinating less explored aspect involves the immunomodulatory behaviors macrophage (MΦ)‐derived exosomes induced by biomaterial surfaces. Herein, untreated surface, nanostructured type I collagen (Col‐I)‐decorated surface titanium implants are chosen to culture MΦs, followed extraction MΦ‐derived investigation their functions mechanisms. results show that group carried plenty inflammatory cytokines, predominantly C ─ motif chemokine ligand 2 (CCL2). After targeting recipient cells, CCL2 on can specifically bind its receptor 2, triggering downstream signaling pathways induce internalization membrane integrin β1 targeted lysosomal degradation, consequently suppressing cells. In contrast, group, Col‐I‐decorated few CCL2, moderating inhibition These findings not only clearly key constituent involved host system, but also potentially target for designing advanced promote repair regeneration.
Language: Английский
Citations
0
Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130703 - 130703
Published: March 1, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract As the global population ages, an increasing number of elderly people are experiencing weakened bone regenerative capabilities, resulting in slower repair processes and associated risks various complications. This review outlines research progress on biomaterials that promote through immunotherapy. examines how manufacturing technologies such as 3D printing, electrospinning, microfluidic technology contribute to enhancing therapeutic effects these biomaterials. Following this, it provides detailed introductions anti‐osteoporosis drug delivery systems, injectable hydrogels, nanoparticles, engineered exosomes, well tissue engineering materials coatings used immunomodulation. Moreover, critically analyzes current limitations biomaterial‐mediated immunotherapy explores future directions for material‐mediated aims inspire new approaches broaden perspectives addressing challenges aging by exploring innovative strategies.
Language: Английский
Citations
0
Nano Letters, Journal Year: 2024, Volume and Issue: 24(46), P. 14574 - 14583
Published: Nov. 8, 2024
The creation of complex multilayer periosteal graft structures is challenging. This study introduced a novel bottom-up approach to assemble cell-laden nanofiber mats into three-dimensional (3D) periosteum mimic, successfully replicating the hierarchical complexity natural periosteum. These mats, which were fabricated by electrospinning, surface modification, and stimulated body fluid (SBF) immersion, are composed nanoscale polycaprolactone (PCL) fibers coated with mineralized collagen layer along fiber orientation. They closely resembled matrix, thereby promoting osteogenic differentiation rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. biomimetic periosteum, constructed via layer-by-layer assembly, offered advantages such as nanofibrous structure, controlled cell distribution, reservoir for osteoprogenitors, enhanced pro-osteogenic potential. calvarial defect model confirmed its potent repair capacity. presents an efficient construct tissue-engineered mimics, holding promise serving grafts orthopedic applications.
Language: Английский
Citations
2
Published: Jan. 1, 2024
Language: Английский
Citations
0