NAVIGATING RHEUMATOID ARTHRITIS: INSIGHTS INTO LIGAND-ANCHORED NANOPARTICLE STRATEGIES FOR ANTI-INFLAMMATORY THERAPY AND RELIEF DOI Creative Commons

Shriya Karmarkar,

Trinette Fernandes,

Zainab Choonia

et al.

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Ligand-based nanotechnology is promising in enhancing targeted drug delivery autoimmune disorders. This study explores molecular targets and new active targeting techniques. These technologies enhance specificity via precise targeting.

Language: Английский

Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy DOI
Л. А. Васильева, Gulnara A. Gaynanova,

E. A. Romanova

et al.

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150

Published: Oct. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Language: Английский

Citations

4
Nanometer preparation of natural bioactive compounds for treatment of rheumatoid arthritis DOI Creative Commons

Junping Zhu,

Xiang Qin, Qi Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101341 - 101341

Published: May 1, 2025

Language: Английский

Citations

0
Amelioration of the rheumatoid arthritis microenvironment using celastrol-loaded silver-modified ceria nanoparticles for enhanced treatment DOI Creative Commons
Xiaoru Zhang,

Xiaguo Fu,

Wanying Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 22, 2025

Rheumatoid arthritis (RA) is characterized by elevated levels of reactive oxygen species (ROS) and a persistent inflammatory microenvironment dominated M1 macrophages, both which contribute to disease progression. To address these pathological features, we developed core-shell nanoplatform consisting silver-modified ceria nanoparticles loaded with celastrol (Ag-CeNP@Cel). This significantly enhances the water solubility reduces its hepato-renal toxicity enabling passive accumulation in inflamed joints. The synergistically combine scavenge excess ROS reprogram macrophages into M2 thereby mitigating responses improving rheumatoid (RAM). Ag-CeNP@Cel exhibited robust therapeutic efficacy safety preclinical models, presenting an innovative approach RA treatment integrating elimination macrophage modulation ameliorate microenvironment. study underscores potential as promising strategy for management.

Language: Английский

Citations

0
NAVIGATING RHEUMATOID ARTHRITIS: INSIGHTS INTO LIGAND-ANCHORED NANOPARTICLE STRATEGIES FOR ANTI-INFLAMMATORY THERAPY AND RELIEF DOI Creative Commons

Shriya Karmarkar,

Trinette Fernandes,

Zainab Choonia

et al.

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Ligand-based nanotechnology is promising in enhancing targeted drug delivery autoimmune disorders. This study explores molecular targets and new active targeting techniques. These technologies enhance specificity via precise targeting.

Language: Английский

Citations

2