Development of a Carvedilol-Loaded Solid Self-Nanoemulsifying System with Increased Solubility and Bioavailability Using Mesoporous Silica Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1592 - 1592

Published: Feb. 13, 2025

This study developed a solid self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of poorly soluble carvedilol using mesoporous silica nanoparticles (MSNs). The liquid (L-SNEDDS) consisted carvedilol, Peceol, Tween 80, and Labrasol in weight ratio 10:25:50:25. SNEDDS was suspended MSN at various ratios spray-dried produce S-SNEDDS. emulsion size, PDI, solubility, dissolution were evaluated make optimal S-SNEDDS, manufactured L-SNEDDS 1000 500, formed nanoemulsion achieved efficient supersaturation compared alone, which significantly improved solubility (approximately 400 times), 5.7 times 60 min), area under curve (AUC) (21.7 maximum plasma concentration (Cmax) (15.7 times). In addition, physicochemical properties S-SNEDDS by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR), particle electron microscopy (SEM) images. showed smaller size than crystalline transformed into an amorphous substance, resulting encapsulation MSN. These results suggest that can be novel biocompatible carrier contributing safer more effective system.

Language: Английский

Glassy Drug Microneedle Array Design: Drug Glass-Forming Ability and Stability

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Glassy microneedles, composed only of drug, provide an intradermal alternative to oral or parenteral drug delivery. Compared microneedles drug–polymer solid dispersions, they offer higher loading while possessing mechanical strength for skin penetration. However, their microneedle structure and associated are reliant on the component glass stability. This study investigates relationships between stability drug-only glass-forming ability (GFA), determined by differential scanning calorimetry (DSC) analysis. The fabricated from six drugs was evaluated at 2–8 °C under nitrogen, 25 °C/60% relative humidity (RH), 40 °C/75% RH. Drug visual assessment appearance, together with DSC powder X-ray diffraction analysis melt cooled outside molds. retained all stored nitrogen 3 months. GFA classes informed dry (nitrogen) environments temperatures below transition temperature. Under controlled conditions, crystallized, except itraconazole. did not inform when exposed water vapor during storage due absorption plasticization. Itraconazole's attributed interaction absorbed liquid crystalline phases present in itraconazole glass. results highlight how glassy is Tg moisture vapor. Results also demonstrate penetration efficiency maintained selecting stabilizing conditions.

Language: Английский

Advances in dissolving microneedles-based drug delivery system for treating dermatological diseases

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106785 - 106785

Published: March 1, 2025

Language: Английский