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Unveiling novel features and phylogenomic assessment of indigenous Priestia megaterium AB-S79 using comparative genomics DOI

Adetomiwa A. Adeniji, Chinenyenwa Fortune Chukwuneme, Emilyn Costa Conceição

et al.

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

ABSTRACT Priestia megaterium strain AB-S79 isolated from active gold mine soil previously expressed in vitro heavy metal resistance and has a 5.7 Mb genome useful for biotechnological exploitation. This study used web-based bioinformatic resources to analyze P. genomic relatedness, decipher its secondary metabolite biosynthetic gene clusters (BGCs), better comprehend taxa. Genes were highly conserved across the 14 P . genomes examined here. The pangenome reflected total of 61,397 protein-coding genes, 59,745 homolog protein family hits, 1,652 singleton hits. There also 7,735 families, including 1,653 families 6,082 families. OrthoVenn3 comparison sequences with 13 other strains, 7 spp., 6 Bacillus spp. highlighted AB-S79’s unique evolutionary trait. antiSMASH identified two key transcription factor binding site regulators genome: zinc-responsive repressor (Zur) antibiotic production activator (AbrC3), plus putative enzymes biosynthesis terpenes ranthipeptides. harbors BGCs siderophores (synechobactins schizokinens), phosphonate, dienelactone hydrolase protein, phenazine (phzF), which is significant this study. Phosphonate particularly showed specificity sp. validating effect expansion contraction. looks be viable source value-added compounds. Thus, contributes theoretical framework systematic metabolic genetic exploitation sp., value-yielding strains. IMPORTANCE explores microbial natural product discovery using mining, focusing on Key findings highlight potential , AB-S79, applications. research shows limited output Africa, emphasizing importance native AB-S79. Additionally, underlines strain’s diverse capabilities, reinforcing suitability as model cell factories foundational role future

Language: Английский

Citations

Draft genome sequence of Priestia megaterium AB-S79 strain isolated from active gold mine DOI