Deciphering the Role of Nanomedicines for the Treatment of Ischemic Stroke DOI
Faizan Ahmad, Anik Karan, Navatha Shree Sharma

et al.

Published: Jan. 1, 2023

Ischemic stroke (IS) affects 15 million people globally which leads to death or disability. Currently, Tissue plasminogen activator (tPA) is the only medication approved by US Food and Drug Administration (FDA) for treating IS. This treatment eliminates brain's blood shortage reperfusion-related adverse effects that cause significant tissue damage. Therefore, novel approaches are urgently needed preserve integrity of blood-brain barrier (BBB) salvageable brain tissue. Nanomedicine opens a new door emerging strategies can be promising therapeutic chapter first discusses pathophysiology different events IS, then available interventions IS followed nanocarriers available. also covers viral vectors extracellular vesicles Also, it focuses on intranasal administration nanomedicines, might cross BBB finally toxicity related completely focused using nanomedicines use

Language: Английский

Toxicological and bioremediation profiling of nonessential heavy metals (mercury, chromium, cadmium, aluminium) and their impact on human health: A review DOI
Harsh Sable, Vandana Singh, Vaishali Kumar

et al.

Annales de Toxicologie Analytique, Journal Year: 2024, Volume and Issue: 36(3), P. 205 - 234

Published: April 7, 2024

Language: Английский

Citations

31
Strategically engineering advanced nanomaterials for heavy-metal remediation from wastewater DOI
Harsh Sable, Vaishali Kumar, Vandana Singh

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216079 - 216079

Published: July 15, 2024

Language: Английский

Citations

19
NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders DOI Creative Commons
Ayodeji O. Egunlusi, Jacques Joubert

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 639 - 639

Published: May 15, 2024

Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by progressive neuronal loss, leading to cognitive, motor, and behavioral impairments. Common examples Alzheimer's disease (AD) Parkinson's (PD). The global prevalence NDs is on the rise, imposing significant economic social burdens. Despite extensive research, mechanisms underlying remain incompletely understood, hampering development effective treatments. Excitotoxicity, particularly glutamate-mediated excitotoxicity, key pathological process implicated in NDs. Targeting N-methyl-D-aspartate (NMDA) receptor, which plays central role holds therapeutic promise. However, challenges, such as blood-brain barrier penetration adverse effects, extrapyramidal have hindered success many NMDA receptor antagonists clinical trials. This review explores molecular antagonists, emphasizing their structure, function, types, future prospects treating research competitive noncompetitive quest for treatments still faces hurdles. partly because same that necessitates blockage under also responsible normal physiological function receptors. Allosteric modulation receptors presents potential alternative, with GluN2B subunit emerging attractive target due its enrichment presynaptic extrasynaptic receptors, are major contributors excitotoxic-induced cell death. low side-effect profiles, selective like ifenprodil radiprodil encountered obstacles poor bioavailability Moreover, selectivity these often relative, they been shown bind other GluN2 subunits, albeit minimally. Recent advancements developing phenanthroic naphthoic acid derivatives offer promise enhanced GluN2B, GluN2A or GluN2C/GluN2D improved pharmacodynamic properties. Additional challenges antagonist conflicting preclinical results, well complexity neurodegenerative poorly defined subtypes. Although multifunctional agents targeting multiple degenerative processes being explored, data limited. Designing antagonists/modulators polycyclic moieties multitarget properties would be addressing disorders. understanding structure coupled collaborative efforts drug design, imperative realizing antagonists/modulators.

Language: Английский

Citations

18
Review—Nanosystems-Enhanced Electrochemical Biosensors for Precision in One Health Management DOI Creative Commons
Harsh Sable, Vaishali Kumar, Vandana Singh

et al.

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(3), P. 037527 - 037527

Published: March 11, 2024

One Health is a comprehensive and cohesive strategy that seeks to effectively manage enhance the well-being of people, animals, ecosystems in sustainable manner. Electrochemical biosensors are indispensable vectors for management, with diverse applications across industrial process control, environmental monitoring, healthcare, microbiology, quality assurance. The integration nanotechnology has propelled innovative sensing algorithms, enhancing efficiency precision biosensors. Nanoscale material amplifies their ability detect molecules single biomolecules nano-biosensors utilizing nanoparticles, nanowires, carbon nanotubes (CNTs), nanorods, quantum dots. Nanomaterials, distinguished by surface functionalities, tunability physical/chemical properties, high detection sensitivity, large area, stability, thermal/electrical conductivity, instrumental architecting nano-biosensors. main limitations current times scalability, cross-sensitivity, complex immobilization pathways, toxicity factor nanosensors, which hazardous ecosystem as well humans. This review explores fundamentals nanotechnology-enabled electrochemical biosensors, encompassing composition, manufacturing materials, applications, highlighting necessity advancing biosensor technology control contamination/human diseases order Health.

Language: Английский

Citations

14
UDP-glucuronosyltransferase is involved in susceptibility of Chironomus kiiensis Tokunaga, 1936 (Diptera: Chironomidae) to insecticides DOI Creative Commons

Chengcheng Fan,

Zexiao Cui,

Tianying Yang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 263, P. 115353 - 115353

Published: Aug. 14, 2023

UDP-glucuronosyltransferases (UGTs) could transform various exogenous and endogenous compounds, which help detoxification of pesticides in insects. To investigate the role UGTs metabolism insecticides Chironomus kiiensis, CkUGT302M1, CkUGT302N1, CkUGT308N1 CkUGT36J1 genes were identified with 1449–1599 bp encoding 482–532 amino acids. Four UGT shared 40.86∼53.36% identity other homologous insect species, expressed all developmental stages, notably larval adult stages. Expression CkUGTs was higher gastric caecum, midgut head. Moreover, expression activity significantly increased C. kiiensis larvae exposure to sublethal concentrations carbaryl, deltamethrin phoxim, respectively. further explore functions genes, effectively silenced 4th instar by RNA interference, resulted mortality dsCkUGT308N1 treated 71.43%, 111.11% 62.50% under doses phoxim at 24-h time point, The study revealed that gene contribute provide a scientific basis for evaluating water pollution pesticides.

Language: Английский

Citations

6
Biosorption of Hexavalent Chromium by Shewanella putrefaciens MTCC 8104: Response Surface Methodology Optimization and Mechanistic Insights DOI
Harsh Sable, Vaishali Kumar, Richa Mishra

et al.

Indian Journal of Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Language: Английский

Citations

2
Harnessing Nature’s Toolbox: Naturally Derived Bioactive Compounds in Nanotechnology Enhanced Formulations DOI Creative Commons

Chetana Sanjai,

Santosh L. Gaonkar, Sushruta S. Hakkimane

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(43), P. 43302 - 43318

Published: Oct. 18, 2024

The vast diversity of plants in nature offers a rich reservoir bioactive compounds that have historically played an integral role pharmacotherapy and continue to serve as primary source novel therapeutic agents. Medicinal contain multitude secondary metabolites with pharmacological potential, making them indispensable drug discovery development. These constituents, inherent herbal remedies, exhibit wide range medicinal properties due their complex chemical compositions structural diversity. Despite the clinical application crude plant extracts is often hindered by limitations, such poor bioavailability, low biostability, variable efficacy. issues can diminish impact plant-derived compounds. Nanotechnology presents innovative approach addressing these challenges through development nanoformulations enhance efficacy This review examines both historical recent studies on synthesis characterization compounds, focusing effectiveness treating various diseases. Additionally, it addresses risks associated direct use medicine, explores extraction isolation techniques, reviews research from past five years nanoformulations, applications disease treatment. also trials conducted over last nanoformulated counterparts, providing insights into translation natural therapeutics.

Language: Английский

Citations

1
Nanotherapeutic Approaches for the Treatment of Rheumatoid Arthritis DOI
Ayushi Sharma, Anjana Goel

Nano LIFE, Journal Year: 2023, Volume and Issue: 13(04)

Published: Aug. 18, 2023

Rheumatoid arthritis (RA) has been known as an autoimmune disease that affects the joint tissues leading to development of stern inflammatory microenvironments. Patients suffering from RA are often recommended take disease-modifying anti-rheumatic drugs DMARDs by health-care professionals. But, utilizing for a prolonged time found cause toxicity in several organs patient including gastrointestinal tract, skin and kidneys. Along with affecting these organs, usage also leads immunosuppression causes varied infections. In recent years, nanomedicine emerged one most potent therapeutic techniques treating RA. This is because its efficacy localizing medicines precisely inflamed joints. Therefore, topic nanomedicine, which potential be utilized delivery specifically joints damaged inflammatory, will primary focus this review. contribute understanding assists regulating progression emphasizing immune regulation, controlled medication release, targeted delivery.

Language: Английский

Citations

2
In-situ scrutiny of the transition melting of pristine (Au) and metal oxide (Au-gallia)-supported plasmonic nanostructures DOI

L. Keerthana,

Gnanaprakash Dharmalingam

Journal of Physics and Chemistry of Solids, Journal Year: 2023, Volume and Issue: 185, P. 111800 - 111800

Published: Nov. 22, 2023

Language: Английский

Citations

2
Curcumin Nanoformulations in Neurodegenerative Diseases DOI
Vandita Kakkar,

Parina Kumari,

Jaspreet Kaur

et al.

Published: Jan. 1, 2023

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration structure and function nervous system, particularly neurons (nerve cells). These primarily affect brain spinal cord, leading to deterioration cognitive abilities, motor skills, overall neurological functioning. They majorly classified as Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), amyotrophic lateral sclerosis (ALS). Curcumin, natural compound derived from turmeric plant, has gained attention for its potential therapeutic effects in neurodegenerative diseases. It is known anti-inflammatory, anti-oxidant, neuroprotective properties. Its use limited due poor water solubility bioavailability. However, usefulness agent hindered comprised bioavailability low aqueous (11 ng/ml) high permeability (log 3.28). Nano-delivery systems such liposomes, polymeric nanoparticles micelles, lipid nanoparticles, emulsions have been extensively explored enhancing curcumin application effective management This book chapter written with focus create complete database on status nanoformulation (s) be developed therapeutics disease. Challenges applications nanoformulations AD, PD, HD, ALS. Emphasis also given regulatory aspects use.

Language: Английский

Citations

1