Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare DOI
Shu Gong, Lu Yan,

Jialiang Yin

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(2), P. 455 - 553

Published: Jan. 4, 2024

In the era of Internet-of-things, many things can stay connected; however, biological systems, including those necessary for human health, remain unable to connected global Internet due lack soft conformal biosensors. The fundamental challenge lies in fact that electronics and biology are distinct incompatible, as they based on different materials via functioning principles. particular, body is curvilinear, yet typically rigid planar. Recent advances design have generated tremendous opportunities wearable bioelectronics, which may bridge gap, enabling ultimate dream healthcare anyone, anytime, anywhere. We begin with a review historical development healthcare, indicating significant trend healthcare. This followed by focal point discussion about new design, particularly low-dimensional nanomaterials. summarize material types their attributes designing bioelectronic sensors; we also cover synthesis fabrication methods, top-down, bottom-up, combined approaches. Next, discuss energy challenges progress made date. addition front-end devices, describe back-end machine learning algorithms, artificial intelligence, telecommunication, software. Afterward, integration systems been applied various testbeds real-world settings, laboratories preclinical clinical environments. Finally, narrate remaining conjunction our perspectives.

Language: Английский

Technology Roadmap for Flexible Sensors DOI Creative Commons
Yifei Luo, Mohammad Reza Abidian, Jong‐Hyun Ahn

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5211 - 5295

Published: March 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Language: Английский

Citations

697
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients DOI Open Access
Minqiang Wang, Yiran Yang, Jihong Min

et al.

Nature Biomedical Engineering, Journal Year: 2022, Volume and Issue: 6(11), P. 1225 - 1235

Published: Aug. 15, 2022

Language: Английский

Citations

507
Wireless battery-free wearable sweat sensor powered by human motion DOI Creative Commons
Yu Song, Jihong Min, You Yu

et al.

Science Advances, Journal Year: 2020, Volume and Issue: 6(40)

Published: Sept. 30, 2020

Wireless wearable sweat biosensors have gained huge traction due to their potential for noninvasive health monitoring. As high energy consumption is a crucial challenge in this field, efficient harvesting from human motion represents an attractive approach sustainably power future wearables. Despite intensive research activities, most harvesters suffer complex fabrication procedures, poor robustness, and low density, making them unsuitable continuous biosensing. Here, we propose highly robust, mass-producible, battery-free platform that efficiently extracts body through flexible printed circuit board (FPCB)-based freestanding triboelectric nanogenerator (FTENG). The judiciously engineered FTENG displays output of ~416 mW m-2 Through seamless system integration management, demonstrate triboelectrically driven able multiplexed wirelessly transmit data the user interfaces Bluetooth during on-body trials.

Language: Английский

Citations

492
SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring DOI Creative Commons
Rebeca M. Torrente‐Rodríguez, Heather Lukas, Jiaobing Tu

et al.

Matter, Journal Year: 2020, Volume and Issue: 3(6), P. 1981 - 1998

Published: Oct. 5, 2020

Language: Английский

Citations

449
Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics DOI
Wenzheng Heng,

Samuel A. Solomon,

Wei Gao

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(16)

Published: Dec. 12, 2021

Abstract Medical robots are invaluable players in non‐pharmaceutical treatment of disabilities. Particularly, using prosthetic and rehabilitation devices with human–machine interfaces can greatly improve the quality life for impaired patients. In recent years, flexible electronic soft robotics have attracted tremendous attention this field due to their high biocompatibility, functionality, conformability, low‐cost. Flexible on will make a promising alternative conventional rigid devices, which potentially revolutionize paradigm future direction medical terms feedback user experience. review, fundamental components materials, structures, mechanisms human‐machine summarized by renowned applications five primary areas: physical chemical sensing, physiological recording, information processing communication, robotic actuation, stimulation. This review further concludes discussing outlook current challenges these technologies as interface robotics.

Language: Английский

Citations

375
Wearable and flexible electrochemical sensors for sweat analysis: a review DOI Creative Commons

Fupeng Gao,

Chunxiu Liu, Lichao Zhang

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 1, 2023

Abstract Flexible wearable sweat sensors allow continuous, real-time, noninvasive detection of analytes, provide insight into human physiology at the molecular level, and have received significant attention for their promising applications in personalized health monitoring. Electrochemical are best choice due to high performance, low cost, miniaturization, wide applicability. Recent developments soft microfluidics, multiplexed biosensing, energy harvesting devices, materials advanced compatibility electrochemical sweat-sensing platforms. In this review, we summarize potential medical methods stimulation collection. This paper provides an overview components recent power supply technologies highlights some typical sensing platforms different types analytes. Finally, ends with a discussion challenges view prospective development exciting field.

Language: Английский

Citations

338
Skin-Interfaced Wearable Sweat Sensors for Precision Medicine DOI
Jihong Min, Jiaobing Tu, Changhao Xu

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 5049 - 5138

Published: March 27, 2023

Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward healthcare. Advances flexible electronics, materials science, electrochemistry have spurred the development of wearable sweat that enable continuous noninvasive screening analytes indicative status. Existing major challenges include: improving extraction sensing capabilities, form factor device for minimal discomfort reliable measurements when worn, understanding clinical value biomarker discovery. This review provides a comprehensive outlines state-of-the-art technologies research strive to bridge these gaps. The physiology sweat, materials, biosensing mechanisms advances, approaches induction sampling are introduced. Additionally, design considerations system-level devices, spanning from strategies prolonged efficient powering wearables, discussed. Furthermore, applications, data commercialization efforts, challenges, prospects precision medicine

Language: Английский

Citations

322
Wearable chemical sensors for biomarker discovery in the omics era DOI Open Access
Juliane R. Sempionatto, José A. Lasalde‐Ramírez, Kuldeep Mahato

et al.

Nature Reviews Chemistry, Journal Year: 2022, Volume and Issue: 6(12), P. 899 - 915

Published: Nov. 15, 2022

Language: Английский

Citations

297
Emerging Telemedicine Tools for Remote COVID-19 Diagnosis, Monitoring, and Management DOI Open Access
Heather Lukas, Changhao Xu, You Yu

et al.

ACS Nano, Journal Year: 2020, Volume and Issue: 14(12), P. 16180 - 16193

Published: Dec. 14, 2020

The management of the COVID-19 pandemic has relied on cautious contact tracing, quarantine, and sterilization protocols while we await a vaccine to be made widely available. Telemedicine or mobile health (mHealth) is well-positioned during this time reduce potential disease spread prevent overloading healthcare system through at-home screening, diagnosis, monitoring. With rise mass-fabricated electronics for wearable portable sensors, emerging telemedicine tools have been developed address shortcomings in diagnostics, monitoring, management. In Perspective, summarize current implementations mHealth sensors COVID-19, highlight recent technological advances, provide an overview how these may utilized better control pandemic.

Language: Английский

Citations

237
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring DOI Creative Commons
Bo Wang, Chuanzhen Zhao, Zhaoqing Wang

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(1)

Published: Jan. 5, 2022

Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is in sweat nanomolar concentrations. Previous wearable sensing systems are limited to analytes the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array exploits previously unreported cortisol aptamer coupled nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced electrical signals on The physiological relevance of as biomarker demonstrated tracking salivary participants Trier Social Stress Test establishing correlations between diurnal saliva samples. These motivated development on-body validation an aptamer-FET array–based smartwatch equipped with custom, multichannel, self-referencing, autonomous source measurement unit enabling seamless, real-time sensing.

Language: Английский

Citations

236