Side Chain Phenyl Isomerization‐Induced Spatial Conjugation for Achieving Efficient NIR‐II Phototheranostic Agents DOI Open Access

Chunbin Li,

Mengfan Yao,

Guoyu Jiang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The contradiction of near‐infrared II (NIR‐II) emission and photothermal effects limits the development phototheranostic agents (PTAs) in many emerging cutting‐edge applications. Organic aggregates present a promising opportunity for balance competitive relaxation processes through manipulation molecular structure packing. Herein, side chain phenyl isomerization‐induced spatial conjugation was proposed constructing A‐D‐A type NIR‐II PTAs with simultaneous enhancement fluorescence brightness properties. Three pairs mutually isomeric fluorophores, whose phenyls respectively located at outside ( o ‐series) inside i chain, were designed synthesized. positional isomerization endows ‐series crystals strong between group on backbone, as well interlocked planar network, which is different to that observed ‐series. Thus, all nanoparticles (NPs) exhibit red‐shifted absorption, enhanced emission, superior properties than their counterparts. A prominent member ‐series, ‐ITNP NPs, demonstrated efficacy facilitating angiography, tumor localization, imaging‐guided therapy. success this strategy paves way precise control aggregation behavior further efficient PTAs.

Language: Английский

Constructing Flexible Crystalline Porous Organic Salts via a Zwitterionic Strategy DOI
Jin Wang, Shengyi Yang, Liang Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(45), P. 31042 - 31052

Published: Nov. 4, 2024

The unique ionic channels and highly polar pore structures have distinguished crystalline porous organic salts (CPOSs) from conventional frameworks in the past decade. Up to now, CPOSs were all constructed by a monoionic strategy, which two types of building units individually bearing anionic or cationic groups introduced, thus increasing complexity synthesis CPOSs. In this study, utilizing stereoisomeric compounds TPE-NS-Z TPE-NS-E both as single unit, zwitterionic strategy was proven feasible constructing Benefiting simplified preparation process reduced difficulty studying aggregation behavior into And also, novel enabled precise control finally obtained through fine-tuning initial units. Surprisingly, special parallel/vertical alternated stacking mode interaction networks crystal structure provided flexible characteristic CPOS-E, further guaranteed multitime controllable release chemicals different solvents.

Language: Английский

Citations

1
Side Chain Phenyl Isomerization‐Induced Spatial Conjugation for Achieving Efficient NIR‐II Phototheranostic Agents DOI Open Access

Chunbin Li,

Mengfan Yao,

Guoyu Jiang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

The contradiction of near-infrared II (NIR-II) emission and photothermal effects limits the development phototheranostic agents (PTAs) in many emerging cutting-edge applications. Organic aggregates present a promising opportunity for balance competitive relaxation processes through manipulation molecular structure packing. Herein, side chain phenyl isomerization-induced spatial conjugation was proposed constructing A-D-A type NIR-II PTAs with simultaneous enhancement fluorescence brightness properties. Three pairs mutually isomeric fluorophores, whose phenyls respectively located at outside (o-series) inside (i-series) chain, were designed synthesized. positional isomerization endows o-series crystals strong between group on backbone, as well interlocked planar network, which is different to that observed i-series. Thus, all nanoparticles (NPs) exhibit red-shifted absorption, enhanced emission, superior properties than their i-series counterparts. A prominent member o-series, o-ITNP NPs, demonstrated efficacy facilitating angiography, tumor localization, imaging-guided therapy. success this strategy paves way precise control aggregation behavior further efficient PTAs.

Language: Английский

Citations

1
A case study: From reductionism to holism DOI
Haoran Wang, Qian Wu, Jong Seung Kim

et al.

Chem, Journal Year: 2024, Volume and Issue: 10(8), P. 2355 - 2357

Published: Aug. 1, 2024

Language: Английский

Citations

0
Side Chain Phenyl Isomerization‐Induced Spatial Conjugation for Achieving Efficient NIR‐II Phototheranostic Agents DOI Open Access

Chunbin Li,

Mengfan Yao,

Guoyu Jiang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The contradiction of near‐infrared II (NIR‐II) emission and photothermal effects limits the development phototheranostic agents (PTAs) in many emerging cutting‐edge applications. Organic aggregates present a promising opportunity for balance competitive relaxation processes through manipulation molecular structure packing. Herein, side chain phenyl isomerization‐induced spatial conjugation was proposed constructing A‐D‐A type NIR‐II PTAs with simultaneous enhancement fluorescence brightness properties. Three pairs mutually isomeric fluorophores, whose phenyls respectively located at outside ( o ‐series) inside i chain, were designed synthesized. positional isomerization endows ‐series crystals strong between group on backbone, as well interlocked planar network, which is different to that observed ‐series. Thus, all nanoparticles (NPs) exhibit red‐shifted absorption, enhanced emission, superior properties than their counterparts. A prominent member ‐series, ‐ITNP NPs, demonstrated efficacy facilitating angiography, tumor localization, imaging‐guided therapy. success this strategy paves way precise control aggregation behavior further efficient PTAs.

Language: Английский

Citations

0