Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Abstract Micro/nano‐scale robotic devices are emerging as a cutting‐edge approach for precision intravascular therapies, offering the potential highly targeted drug delivery. While employing micro/nanorobotics stroke treatment is promising strategy due to its ability localize therapy and minimize dosage, current methods require prolonged durations, increasing risk of nerve tissue necrosis from extended hypoxia. Here programmable colloidal microswarm capable rapidly detaching blood clots vessel wall developed, enabling swift recanalization without need complete clot degradation. More importantly, detached debris, despite their random shapes, functions magnetic “debris‐robots” can be efficiently propelled through helical swimming within flowing vessels, followed by retrieval using catheter suction. The entire process—including delivery, controlled locomotion, detachment, retrieval—can completed in approximately half an hour, significantly saving time compared critical “Golden 6 hours” window treatment. This procedure greatly minimizes nanoparticle exposure bloodstream lowers secondary clotting distal marking significant advancement robotic‐assisted thrombolysis.

Language: Английский