Advances in Microfluidics-Enabled Dimensional Design of Micro-/Nanomaterials for Biomedical Applications: A Review

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Biomedical materials are of great significance for preventing and treating major diseases protecting human health. At present, more stringent requirements have been put forward the preparation methods dimension control biomedical based on urgent demand high-performance materials, especially existence various physiological size thresholds in vitro/in vivo. Microfluidic platforms break limitations traditional micro-/nanomaterial synthesis, which provide a miniaturized highly controlled environment size-dependent biomaterials. In this review, basic conceptions technical characteristics microfluidics first described. Then syntheses with different dimensions (0D, 1D, 2D, 3D) driven by systematically summarized. Meanwhile, applications microfluidics-driven including diagnosis, anti-inflammatory, drug delivery, antibacterial, disease therapy, discussed. Furthermore, challenges developments research field further proposed. This work is expected to facilitate convergence between bioscience engineering communities continue contribute emerging field.

Language: Английский

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Split-Ring Structured All-Inorganic Perovskite Photodetector Arrays for Masterly Internet of Things

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 15(1)

Published: Nov. 29, 2022

Abstract Photodetectors with long detection distances and fast response are important media in constructing a non-contact human–machine interface for the Masterly Internet of Things (MIT). All-inorganic perovskites have excellent optoelectronic performance high moisture oxygen resistance, making them one promising candidates high-performance photodetectors, but simple, low-cost reliable fabrication technology is urgently needed. Here, dual-function laser etching method developed to complete both lyophilic split-ring structure electrode patterning. This novel can capture perovskite precursor droplet efficiently achieve uniform compact deposition CsPbBr 3 films. Furthermore, our devices based on laterally conducting structured photodetectors possess outstanding performance, including maximum responsivity 1.44 × 10 5 mA W −1 , time 150 μs 1.5 kHz one-unit area < 4 –2 mm 2 . Based these photodetector arrays, we realized three-dimensional gesture up 100 distance 600 s speed detection, low-cost, integrative, interfaces. Finally, applied this MIT wearable flexible digital recognition watch panel, safe comfortable central controller integrated car screen, remote control robot, demonstrating broad potential applications.

Language: Английский

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Nanoplasmonic Single‐Tumoroid Microarray for Real‐Time Secretion Analysis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

Organoid tumor models have emerged as a powerful tool in the fields of biology and medicine such 3D structures grown from cells recapitulate better characteristics, making these tumoroids unique for personalized cancer research. Assessment their functional behavior, particularly protein secretion, is significant importance to provide comprehensive insights. Here, label-free spectroscopic imaging platform presented with advanced integrated optofluidic nanoplasmonic biosensor that enables real-time secretion analysis single tumoroids. A novel two-layer microwell design isolates tumoroids, preventing signal interference, microarray configuration allows concurrent multiple The dual capability combining time-lapse plasmonic spectroscopy bright-field microscopy facilitates simultaneous observation dynamics, motility, morphology. demonstrated colorectal derived both cell lines patient samples investigate vascular endothelial growth factor (VEGF-A) growth, movement under various conditions, including normoxia, hypoxia, drug treatment. This platform, by offering approach nanophotonics monitor can pave way new applications fundamental biological studies, screening, development therapies.

Language: Английский

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Micropatterned Polymer Nanoarrays with Distinct Superwettability for a Highly Efficient Sweat Collection and Sensing Patch

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Abstract Wearable sweat sensor offers a promising means for noninvasive real‐time health monitoring, but the efficient collection and accurate analysis of remains challenging. One obstacles is to precisely modulate surface wettability microfluidics achieve collection. Here facile initiated chemical vapor deposition (iCVD) method presented grow pattern polymer nanocone arrays with distinct superwettability on polydimethylsiloxane microfluidics, which facilitate highly transportation The nanoarray synthesized by manipulating monomer supersaturation during iCVD induce controlled nucleation preferential vertical growth fluorinated polymer. Subsequent selective conformal hydrogel nanolayer results in superhydrophilic floor walls within microchannel that provide large capillary force superhydrophobic ceiling drastically reduces flow friction, enabling rapid transport along varied directions. A carbon/hydrogel/enzyme nanocomposite electrode then fabricated sequential porous carbon nanoparticles nanocoating sensitive stable detection. Further encapsulation assembled sweatsensing patch imparts self‐cleaning water‐proof capability. Finally, sensing demonstrates glucose lactate detection on‐body test.

Language: Английский

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Highly durable, thermally stable, semi-transparent superhydrophobic surfaces for easy-cleaning of contaminants

Progress in Organic Coatings, Journal Year: 2023, Volume and Issue: 179, P. 107537 - 107537

Published: March 28, 2023

Language: Английский

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Precisely writing/printing hydrogel patterns on polymer surfaces

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 149851 - 149851

Published: Feb. 19, 2024

Language: Английский

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Virus detection light diffraction fingerprints for biological applications

Science Advances, Journal Year: 2024, Volume and Issue: 10(11)

Published: March 13, 2024

The transmission of viral diseases is highly unstable and contagious. As the carrier virus transmission, cell an important factor to explore mechanism disease. However, there still a lack effective means continuously monitor process infection in cells, no rapid, high-throughput method assess status infection. On basis light diffraction fingerprint we applied gray co-occurrence matrix, set two parameters effectively distinguish time visualized cells high throughput. We provide efficient nondestructive testing for selection excellent livestock poultry breeds at cellular level. Meanwhile, our work provides detection methods recessive human-to-human, animal-to-animal, zoonotic inhibit block their further development.

Language: Английский

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Controlling Frost Propagation on Polymeric Surfaces Using SI‐ATRP Chemical Micropatterning

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Micropatterned surfaces with both hydrophilic and hydrophobic regions are relevant for a wide range of applications from fuel cells to water harvesting systems. The preferential nucleation on can also be used control frost chemically patterned surfaces. So far, this concept has been tested brittle silicon only few different sizes shapes regions. In work, the controlled icing is investigated five polymeric surface energies modified by micropatterning them three types polymer brushes. Frost formation propagation resulting varying wettability monitored quantified using high‐resolution thermal imaging. study proves that over achieved commodity polymers. addition influencing time location ice nucleation, local patterning affects freezing mode rate due its impact continuity thickness molecular layers (MWL). These results show state MWLs key controlling events

Language: Английский

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Partition-Less Digital Immunoassay Using Configurable Topographic Nanoarrays for Extracellular Vesicle Diagnosis of Ewing Sarcoma

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Emerging digital bioassays provide opportunities for bioanalysis and clinical diagnostics due to their improved analytical performance. Prevailing digitization strategies rely on partitioning single molecules into discrete compartments which bead-based capture may be used. Herein we report a partition-free enzyme-linked immunosorbent assay (dELISA) named microfluidic Topographically Intensified, Partition-less dELISA (μTIP-dELISA). Our method builds single-molecule signal amplification technique that employs simple micropost device generate topographic nanogap array significantly enhance surface-bound enzymatic reactions. Compared existing methods, our approach features appreciable simplicity enhanced adaptability as it obviates the needs sophisticated fabrication, complicated workflow off-line immunomagnetic capture, ultralow-volume compartmentalization. Moreover, μTIP-dELISA integrates inherent advantages of microfluidics in improving performance throughput enhancing scalability automation. As proof-of-concept potential biomedical applications, adapted extracellular vesicle (EV)-based liquid biopsy diagnosis pediatric cancer, Ewing sarcoma (EWS). technology confers >300-fold improvement over conventional ELISA detecting four EWS protein biomarkers. We demonstrated highly sensitive specific detection cases with machine-learning-defined four-marker EV signature. The markers were further tested assess age prognostic factor, resulting an overall accuracy 97% classifying control, adult subjects. Overall, envision μTIP strategy could promote development adaptation useful tool many malignancies.

Language: Английский

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One-Step Fabrication of Packaged Glass Microheater Using Selective Laser Welding

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

The increasing demand for miniaturized and versatile microdevices has driven advancements in micropatterning technologies; however, packaging considerations are often overlooked or addressed with basic additions. This study introduces a new selective laser welding process facilitated by silver (Ag) thin film, enabling simultaneous single step. In the proposed method, Ag film serves as absorber welded area, where it transitions to fully insulating state, while unwelded areas, remaining an electrode without transitions. Mathematical modeling heat transfer simulations were conducted examine energy mechanism determine optimal thickness of film. Laser scan paths designed Joule heating microheater generated subsequent welding. was fabricated hermetically packaged between glass substrates. Finally, reusable cell culture tester demonstrate practical applicability microheater. prototype directly applicable requiring additional packaging. Moreover, demonstrated consistent performance even after washing reuse, indicating its feasibility devices. These results indicate that process, demonstrating potential advancing technologies diverse applications, is promising approach manufacturing microdevices.

Language: Английский

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