Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus DOI Creative Commons

Mona Yassine,

Soha A. Hassan,

Lea Aylin Yücel

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2202 - 2202

Published: Sept. 27, 2024

: Chronic liver diseases such as hepatic tumors can affect the brain through liver-brain axis, leading to neurotransmitter dysregulation and behavioral changes. Cancer patients suffer from fatigue, which be associated with sleep disturbances. Sleep is regulated via two interlocked mechanisms: homeostatic regulation circadian system. In mammals, hypothalamic suprachiasmatic nucleus (SCN) key component of It generates rhythms in physiology behavior controls their entrainment surrounding light/dark cycle. Neuron-glia interactions are crucial for functional integrity SCN. Under pathological conditions, oxidative stress compromise these thus timekeeping entrainment. To date, little known about impact peripheral pathologies hepatocellular carcinoma (HCC) on

Language: Английский

The interplay between sleep and cancer-related fatigue in breast cancer: A casual and computer-simulated network analysis DOI Creative Commons

Hongman Li,

Ying Xiong, Qihan Zhang

et al.

Asia-Pacific Journal of Oncology Nursing, Journal Year: 2025, Volume and Issue: unknown, P. 100692 - 100692

Published: March 1, 2025

Sleep problems and cancer-related fatigue are common symptoms in women for breast cancer, during after treatment. Identifying key intervention targets this symptom cluster may improve patient reported outcomes. This study aimed to explore the relationship between sleep identify optimal targets. In "Be Resilient Breast Cancer" program, self report data were collected on Multidimensional Fatigue Symptom Inventory-Short Form Pittsburgh Quality Index. Gaussian network analysis was employed central nodes, while a Bayesian explored their causal relationships. Computer-simulated interventions used core as intervention. General (Str ​= ​0.95, Bet ​7, Clo ​0.007) considered node with strongest centrality. The daytime dysfunction item quality index had bridge strength. Core identified by computer-simulated analysis. is predictor of from casual networking perspective. latency should be targeted break chained interaction fatigue.

Language: Английский

Citations

0
A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto’s Thyroiditis: Analysis of Asthenia as Admission Complaint DOI Creative Commons

Ana Valea,

Mihai Costăchescu,

Mihaela Stanciu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1380 - 1380

Published: Oct. 27, 2024

Background: Amid the large panel of autoimmune thyroid diseases, Hashimoto’s thyroiditis (HT) represents a major point across multidisciplinary daily practice. When it comes to clinical picture, particularly in regard asthenia (also described as “fatigue” or “decreased energy”), differential diagnosis is challenging, and meticulous anamnesis should be backed up by focused lab investigations. Our objective was analyze newly diagnosed patients with HT relationship presence an admission complaint. Methods: This retrospective, multi-centric, real-life study conducted secondary endocrine units (university hospitals) from July 2022 2023. The exclusion criteria were COVID-19 infection; active malignancy, etc. Results: cohort (N = 120) included group (AS, 49.2%) non-AS similar age (49.3 ± 14.7 vs. 47.1 14.8 y, p 0.426). Headache more frequent AS (35.6% 18%, 0.03). Thyroid function HT-related antibodies assays between groups show no correlation serum total cholesterol triglycerides, respectively. TSH levels did not vary among sub-groups (p 0.701). One third studied population affected hypothyroidism (TSH > 4.5 μIU/mL), being seen at higher rate (39%) (23%). Total positively correlated patients’ (r 0.180, 0.049) triglycerides 120; r 0.324, < 0.001), found only 0.246, 0.006, respectively, 0.319, 0.001). Conclusions: analysis pinpointed fact that, practice, complaint seems less indicator underlying dysfunction level against without full picture thyrotoxicosis myxoedema.

Language: Английский

Citations

0
Análise da qualidade de vida e sono de pacientes em tratamento oncológico DOI Creative Commons
José Silva, Giovanna Vallim Jorgetto, Sandra Soares Mendes

et al.

Cuadernos de Educación y Desarrollo, Journal Year: 2024, Volume and Issue: 16(11), P. e6408 - e6408

Published: Nov. 19, 2024

O diagnóstico de câncer afeta tanto a saúde física quanto psicológica dos pacientes, comprometendo qualidade vida. Durante o tratamento, alterações no sono, causadas por fatores como mudanças bioquímicas e sintomas da doença, agravam ainda mais esse impacto negativo. presente estudo transversal quantitativo investigou relação entre vida padrão sono em pacientes oncológicos. A amostra, composta 54 tratamento oncológico pelo Sistema Único Saúde uma instituição oncológica do interior São Paulo, foi avaliada meio questionário sociodemgráfico hábitos vida, através EORTC QLQ-C30 Índice Qualidade Sono Pittsburgh (PSQI). Os resultados indicaram que os prevalentes, dor, fadiga insônia, impactaram significativamente funcionalidade emocional pacientes. Além disso, 53,7% relataram acordar durante noite, 61,1% faziam uso medicamentos para dormir. Houve correlação negativa significativa subjetiva (r = -0,89; p < 0,001). Esses achados reforçam importância intervenções abordem destacando necessidade um cuidado multidisciplinar melhorar bem-estar geral

Citations

0
Associations Between Cancer-Related Fatigue and Healthcare Use During Cancer Follow-Up Care: A Survey-Administrative Health Data Linkage Study DOI Creative Commons
Robin Urquhart, Cynthia Kendell, Lynn Lethbridge

et al.

Current Oncology, Journal Year: 2024, Volume and Issue: 31(11), P. 7352 - 7362

Published: Nov. 19, 2024

Little is known about the impacts of fatigue after cancer treatment, including whether cancer-related people's use healthcare. This study sought to examine how healthcare completing treatment. A population-based survey was administered in Nova Scotia, Canada, survivors' experiences and needs Respondents included survivors breast, melanoma, colorectal, prostate, hematologic, young adult cancers who were 1-3 years post-treatment. Survey responses linked registry, physicians' claims, hospitalization, ambulatory care data. Data analyzed descriptively using regression models. The final cohort 823 respondents. Younger respondents reported higher levels compared older More females than males fatigue. Upon adjusted analyses, those with had lower odds being discharged primary for their follow-up (odds ratio = 0.71,

Language: Английский

Citations

0
Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus DOI Creative Commons

Mona Yassine,

Soha A. Hassan,

Lea Aylin Yücel

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2202 - 2202

Published: Sept. 27, 2024

: Chronic liver diseases such as hepatic tumors can affect the brain through liver-brain axis, leading to neurotransmitter dysregulation and behavioral changes. Cancer patients suffer from fatigue, which be associated with sleep disturbances. Sleep is regulated via two interlocked mechanisms: homeostatic regulation circadian system. In mammals, hypothalamic suprachiasmatic nucleus (SCN) key component of It generates rhythms in physiology behavior controls their entrainment surrounding light/dark cycle. Neuron-glia interactions are crucial for functional integrity SCN. Under pathological conditions, oxidative stress compromise these thus timekeeping entrainment. To date, little known about impact peripheral pathologies hepatocellular carcinoma (HCC) on

Language: Английский

Citations

0