The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
A catalytic one-pot cascade dehydrogenative cyclization of 1-(2-aminophenyl)ethanone using primary alcohols is presented. The reaction catalyzed by an earth-abundant manganese pincer complex NNSe ligand, without any solvent, additives, base, or hydrogen acceptor, liberating dihydrogen and water as the only byproducts. Compared to earlier reported four-step coupling protocol, a single step required synthesize 2-aryl-2,3-dihydroquinolin-4(1H)-ones.
Language: Английский