Circadian Clock Regulates Inflammation and the Development of Neurodegeneration

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Sept. 14, 2021

The circadian clock regulates numerous key physiological processes and maintains cellular, tissue, systemic homeostasis. Disruption of machinery influences activities involved in immune response brain function. Moreover, Immune activation has been closely linked to neurodegeneration. Here, we review the molecular diurnal variation activity. We summarize control immunity both central peripheral cells, as well regulation cells that are implicated explore important role inflammation on modulates cellular metabolism, which could be a mechanism underlying control. also discuss interventions Targeting clocks potential strategy for prevention treatment neurodegenerative diseases.

Language: Английский

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Personalized reference intervals: from theory to practice

Critical Reviews in Clinical Laboratory Sciences, Journal Year: 2022, Volume and Issue: 59(7), P. 501 - 516

Published: May 17, 2022

Using laboratory test results for diagnosis and monitoring requires a reliable reference to which the can be compared. Currently, most data is derived from population, patients in this context are considered members of population group rather than individuals. However, such has limitations when used as an individual. A patient's preferably should compared with their own, individualized intervals (RI), i.e. personalized RI (prRI).The prRI based on homeostatic model calculated using individual's previous obtained steady-state situation estimates analytical (CVA) biological variation (BV). BV calculate (within-subject variation, CVI) or own (within-person CVP). Statistically, prediction interval provides useful tool (i.e. prRI) future observation measurements. With development information technology, millions stored processed medical laboratories, allowing implementation medicine. PrRI each individual made available part system continually updated new become available.In review, we summarize population-based disease, provide outline concept different approaches its determination, including statistical considerations deriving prRI, discuss aspects must further investigated prior clinical practice.

Language: Английский

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Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism

Biology, Journal Year: 2023, Volume and Issue: 13(1), P. 22 - 22

Published: Dec. 30, 2023

This study explores the relationship between light features of Arctic spring equinox and circadian rhythms, sleep metabolic health. Residents (N = 62) provided week-long actigraphy measures, including exposure, which were related to body mass index (BMI), leptin cortisol. Lower wrist temperature (wT) higher evening blue exposure (BLE), expressed as a novel index, nocturnal excess (NEIbl), most sensitive measures associated with BMI. A BMI was linked BLE within distinct time windows. These associations present specifically in carriers MTNR1B rs10830963 G-allele. larger wake-after-sleep onset (WASO), smaller 24 h amplitude earlier phase activity rhythm leptin. Higher cortisol an M10 our other Daylight Deficit Index light, DDIbl. We also found sex-, age- population-dependent differences parametric non-parametric indices BLE, wT physical activity, while there no any characteristics. Overall, this determined markers predictive health showed that these are melatonin receptor polymorphism.

Language: Английский

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Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism

Biology, Journal Year: 2023, Volume and Issue: 12(4), P. 539 - 539

Published: March 31, 2023

Like other biological functions, food intake and energy metabolism display daily rhythms controlled by the circadian timing system that comprises a main clock numerous secondary clocks in brain peripheral tissues. Each delivers local temporal cues based on intracellular transcriptional translational feedback loops are tightly interconnected to nutrient-sensing pathways. Genetic impairment of molecular alteration rhythmic synchronizing cues, such as ambient light at night or mistimed meals, lead disruption that, turn, negatively impacts metabolic health. Not all sensitive same signals. The master suprachiasmatic nuclei hypothalamus is mostly synchronized and, lesser extent, behavioral coupled arousal exercise. Secondary generally phase-shifted timed associated with feeding, exercise, changes temperature. Furthermore, both modulated calorie restriction high-fat feeding. Taking into account regularity duration eating periods, chronotype, sex, chrononutritional strategies may be useful for improving robustness rhythmicity maintaining even restoring appropriate balance.

Language: Английский

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Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans

Endocrinology, Journal Year: 2017, Volume and Issue: 158(5), P. 1074 - 1084

Published: March 15, 2017

Most organisms, including humans, have developed an intrinsic system of circadian oscillators, allowing the anticipation events related to rotation Earth around its own axis. The mammalian timing orchestrates nearly all aspects physiology and behavior. Together with systemic signals, emanating from central clock that resides in hypothalamus, peripheral oscillators orchestrate tissue-specific fluctuations gene expression, protein synthesis, posttranslational modifications, driving overt rhythms There is increasing evidence on essential roles operative metabolically active organs regulation body glucose homeostasis. Here, we review some recent findings molecular cellular makeup implications temporal coordination metabolism health disease.

Language: Английский

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