Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation DOI Open Access
Alina Malita,

Olga I. Kubrak,

Xiaokang Chen

et al.

Published: Sept. 18, 2024

Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate JAK-STAT cells, including those of blood-brain barrier (BBB). This activity maintains during oxidative-stress-induced intestinal disturbances, suggesting glia inhibits wake-promoting facilitate sleep-dependent restoration under these conditions. We find enteric peptide Allatostatin A (AstA) enhances wakefulness, stress, gut-derived 2/3 AstA receptor expression BBB glia, thereby sustaining an state inflammation or illness. Taken together, our work identifies gut-to-glial communication couples with homeostasis disease, enhancing sickness, contributes understanding how disturbances arise gastrointestinal disturbances.

Language: Английский

Sports and Immunity, from the recreational to the elite athlete DOI Creative Commons
Richard Baskerville,

L M Castell,

Stéphane Bermon

et al.

Infectious Diseases Now, Journal Year: 2024, Volume and Issue: 54(4), P. 104893 - 104893

Published: March 24, 2024

The pivotal role of the immune system in physical activity is well-established. While interactions are complex, they tend to constitute discrete responses. Moderate intensity exercise causes leukocytosis with a mild anti-inflammatory cytokine profile and immunoenhancement. Above threshold intensity, lactate-mediated IL-6 release proinflammatory state followed by depressed inflammatory state, which stimulates adaptation longer term cardiometabolic enhancement. Exercise-related responses modulated sex, age immunonutrition. At all ability levels, these factors collectively affect balance between enhancement or overload dysfunction. Excessive training, mental stress insufficient recovery risks cell exhaustion hypothalamic pituitary axis (HPA) causing immunodepression negative impacts on performance general health. Participation sport provides additional benefits terms ensuring regularity, social inclusion, well-being healthier life choices diet reduced smoking alcohol, thereby consolidating healthy lifestyles Significant differences exist recreational professional athletes inherent characteristics, training resilience stresses arising from competition schedules, travel-related infections stress. Exercise immunology examines central immunity physiology straddles multiple disciplines ranging neuroendocrinology nutrition genetics, aim guiding train optimally safely. This review brief outline main exercise, some influencing factors, current guidance maintaining

Language: Английский

Citations

4
Studying Cellular Senescence Using the Model Organism Drosophila melanogaster DOI

Xanthippi P. Louka,

Sentiljana Gumeni, Ioannis P. Trougakos

et al.

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 281 - 299

Published: Jan. 1, 2025

Language: Английский

Citations

0
Leptina: descripción de su intrigante biología. Una revisión. Parte I DOI

Yara Irene López-Dionicio,

Miguel Ortíz-Flores, Isabel Carrillo‐Hidalgo

et al.

Cardiovascular and Metabolic Science, Journal Year: 2025, Volume and Issue: 36(1), P. 58 - 69

Published: Jan. 1, 2025

Citations

0
Maternal Iron Deficiency Modulates Antioxidant Status and Longevity in a Sex-Dependent Manner in Drosophila melanogaster DOI

Saudat Faruk,

Kasimu Ibrahim Ghandi,

Abdullahi Y. Abbas

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Background: Maternal iron deficiency (ID) disrupts both maternal and offspring health by impairing status antioxidant defenses. This study examines the intergenerational effects of ID rapamycin intervention on Drosophila melanogaster. Rapamycin is known for promoting autophagy, longevity, activity. Method: Female flies (F0) were subjected to an iron-deficient diet 14 days, followed a 30-day with either normal or rapamycin-treated diet. After chelation, some F0 females crossed males produce F1 offspring. Physiological, biochemical, gene expression changes assessed in after days chelation 30 interventions. Post-eclosion evaluations conducted flies, along 60-day survival generations. Result: In females, significantly reduced (p < 0.0001) body weight, levels, enzyme while increasing GSH levels. Gene showed significant 0.05) storage (Fer1HCH), autophagy (ATG1), telomere-related genes (dHeT-A, dTahre, dTart). A partially restored levels survival, improved antioxidants but had mixed expression. male/female exhibited reduced/increased respectively, also increased median weight female their survival. Conclusion: has lasting effects, diets restoring enhances defenses reduces particularly females.

Language: Английский

Citations

0
Professional phagocytes are recruited for the clearance of obsolete nonprofessional phagocytes in the Drosophila ovary DOI Creative Commons
Alexandra Y. Chasse, Shruthi Bandyadka,

Max C. Wertheimer

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Cell death is an important process in the body, as it occurs throughout every tissue during development, disease, and regeneration. Phagocytes are responsible for clearing away dying cells typically characterized either professional or nonprofessional phagocytes. Professional phagocytes, such macrophages, found nearly part of body while epithelial cells, type. However, there organs that considered “immune-privileged” they have little to no immune surveillance rely on phagocytes engulf cells. These surrounded by barriers protect from viruses, bacteria, perhaps even The Drosophila ovary immune-privileged, however presence hemocytes, macrophages , around suggests may a potential function. Here we analyze hemocyte localization functions response starvation-induced cell ovary. Hemocytes were accumulate oviduct vicinity mature eggs follicle debris. Genetic ablation hemocytes revealed affects oogenesis phagocytose ovarian debris their absence fecundity decreases. Unpaired3, IL-6 like cytokine, was be required recruitment clear obsolete findings demonstrate role ovary, providing more thorough understanding phagocyte communication clearance previously thought immune-privileged organ.

Language: Английский

Citations

0
Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation DOI
Alina Malita,

Olga I. Kubrak,

Xiaokang Chen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 30, 2024

Abstract Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate JAK-STAT cells, including those of blood-brain barrier (BBB). This activity maintains during oxidative-stress-induced intestinal disturbances, suggesting glia inhibits wake-promoting facilitate sleep-dependent restoration under these conditions. We find enteric peptide Allatostatin A (AstA) enhances wakefulness, stress, gut-derived 2/3 AstA receptor expression BBB glia, thereby sustaining an state inflammation or illness. Taken together, our work identifies gut-to-glial communication couples with homeostasis disease, enhancing sickness, contributes understanding how disturbances arise gastrointestinal disturbances.

Language: Английский

Citations

0
Hormonal regulation and disruption in invertebrates – an historical perspective and recent findings DOI
Anapaula Sommer Vinagre, Angela B. Lange, João C. R. Cardoso

et al.

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 593, P. 112335 - 112335

Published: July 30, 2024

Language: Английский

Citations

0
Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation DOI Open Access
Alina Malita,

Olga I. Kubrak,

Xiaokang Chen

et al.

Published: Sept. 18, 2024

Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate JAK-STAT cells, including those of blood-brain barrier (BBB). This activity maintains during oxidative-stress-induced intestinal disturbances, suggesting glia inhibits wake-promoting facilitate sleep-dependent restoration under these conditions. We find enteric peptide Allatostatin A (AstA) enhances wakefulness, stress, gut-derived 2/3 AstA receptor expression BBB glia, thereby sustaining an state inflammation or illness. Taken together, our work identifies gut-to-glial communication couples with homeostasis disease, enhancing sickness, contributes understanding how disturbances arise gastrointestinal disturbances.

Language: Английский

Citations

0
Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation DOI Open Access
Alina Malita,

Olga I. Kubrak,

Xiaokang Chen

et al.

Published: Sept. 18, 2024

Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show interleukin-6-like cytokine signaling Drosophila gut to brain glial cells regulates sleep. Under healthy conditions, this pathway wakefulness. However, elevated in response oxidative stress – triggered by immune and inflammatory responses intestine induces The cytokines Unpaired 2 -3 upregulated enteroendocrine activate JAK-STAT cells, including those of blood-brain barrier (BBB). This activity maintains during oxidative-stress-induced intestinal disturbances, suggesting glia inhibits wake-promoting facilitate sleep-dependent restoration under these conditions. We find enteric peptide Allatostatin A (AstA) enhances wakefulness, stress, gut-derived 2/3 AstA receptor expression BBB glia, thereby sustaining an state inflammation or illness. Taken together, our work identifies gut-to-glial communication couples with homeostasis disease, enhancing sickness, contributes understanding how disturbances arise gastrointestinal disturbances.

Language: Английский

Citations

0