Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

Transmembrane and coiled-coil domain family 3 gene is a novel target of hepatic peroxisome proliferator-activated receptor γ in fatty liver disease

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: unknown, P. 112379 - 112379

Published: Sept. 1, 2024

Language: Английский

Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient secretion. Its characteristic pathophysiological processes involve the interaction of multiple mechanisms. In recent years, globally, prevalence T2DM has shown sharp rise due to profound changes in socio-economic structure, persistent influence environmental factors, complex role genetic background. It worth noting that most patients show significant IR, which further exacerbates difficulty progression prevention. process extensively exploring pathogenesis T2DM, dynamic equilibrium gut microbes its diverse activities have increasingly emphasized central T2DM. Bile acids (BAs) metabolism, as crucial link between development not only precisely regulates lipid absorption metabolism but also profoundly influences glucose homeostasis energy balance through intricate signaling pathways, thus playing pivotal IR This review aims delve into specific mechanism BAs contribute especially emphasizing how mediate transformation based on current traditional Chinese medicine research. Ultimately, it seeks offer new insights prevention treatment Diet, genetics, environment intricately sculpt microbiota influencing T2DM-IR. The research illuminated impact single herbal medicine, TCM formulae, external therapeutic methods such electroacupuncture pool perturbations structure. affects well sensitivity. Additionally, pathways including BA-FXR-SHP, BA-FXR-FGFR15/19, BA-FXR-NLRP3, BA-TGR5-GLP-1, BAs-TGR5/FXR been identified significantly alter blood levels improve IR. These findings novel approaches for enhancing managing disorders among with

Language: Английский