14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 11, 2025
Abstract
14‐3‐3
proteins
are
highly
conserved
that
regulate
numerous
cellular
processes
mostly
through
phosphorylation‐dependent
protein–protein
interactions.
In
the
heart
play
critical
roles
in
cardiac
conduction
pathways,
excitation–contraction
(EC)
coupling,
development
and
stress
responses.
This
review
summarizes
current
understanding
of
regulation
function,
with
particular
emphasis
on
its
role
ion
channel
β‐adrenergic
signalling.
We
discuss
how
act
three
main
mechanisms
–
masking,
clamping,
scaffolding
to
target
proteins,
including
Cx43,
Ca
V
1.2,
Na
1.5,
various
potassium
channels.
The
seven
mammalian
isoforms
display
distinct
but
overlapping
functions,
tissue‐specific
expression
patterns
isoform‐specific
phosphorylation
dimerization.
Recent
work
has
revealed
14‐3‐3's
importance
responses,
where
it
generally
serves
a
cardioprotective
role.
However
some
pathological
contexts
such
as
ischaemia–reperfusion
injury,
can
be
detrimental.
highlight
emerging
themes
biology,
prolonging
Understanding
complex
targets
presents
both
opportunities
challenges
for
therapeutic
development.
image
Language: Английский
Regulation of H9C2 cell hypertrophy by 14-3-3η via inhibiting glycolysis
Sha Wan,
No information about this author
Songhao Wang,
No information about this author
Xianfei Yang
No information about this author
et al.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(7), P. e0307696 - e0307696
Published: July 22, 2024
It
has
been
reported
that
Ywhah
(14-3-3η)
reduces
glycolysis.
However,
it
remains
unclear
about
the
downstream
mechanism
by
which
glycolysis
is
regulated
14-3-3η
in
cardiac
hypertrophy.
As
an
important
regulator,
Yes-associated
protein
(YAP)
interacts
with
to
participate
initiation
and
progression
of
various
diseases
vivo.
In
this
study,
model
H9C2
cardiomyocyte
hypertrophy
was
established
triiodothyronine
(T3)
or
rotenone
stimulation
probe
into
action
14-3-3η.
Interestingly,
overexpression
attenuated
T3
induced
decreased
cardiomyocytes,
whereas
knockdown
had
opposite
effect.
Mechanistically,
can
reduce
expression
level
YAP
bind
its
nuclear
translocation.
addition,
changing
may
affect
lactate
dehydrogenase
A
(LDHA),
a
glycolysis-related
protein.
Meanwhile,
LDHA
also
possible
target
for
mediate
based
on
changes
pyruvate,
substrate
LDHA.
Collectively,
suppress
via
decreasing
nucleus
translocation
glycolysis,
indicates
could
be
promising
inhibiting
Language: Английский