Exploring Angiotensin II and Oxidative Stress in Radiation-Induced Cataract Formation: Potential for Therapeutic Intervention DOI Creative Commons
Vidya P. Kumar,

Yali Kong,

Riana Dolland

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1207 - 1207

Published: Oct. 8, 2024

Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require deep understanding of the mechanisms underlying RIC formation (RICF). This study investigates roles angiotensin II (Ang II) oxidative stress in development, with focus on their combined effects lens transparency cellular function. Key include generation reactive oxygen species (ROS) damage proteins lipids, as well impact Ang inflammatory responses apoptosis. While ROS from water radiolysis is established, RICs less understood. intensifies by activating type 1 receptors (AT1Rs) epithelial cells, resulting increased production responses. leads protein aggregation, lipid peroxidation, apoptosis, ultimately compromising contributing cataract formation. Recent studies highlight II's dual role promoting both inflammation, which accelerates development. pose substantial concern due widespread prevalence quality life. Targeting signaling simultaneously could promising approach. Continued research necessary validate these explore efficacy preventing or reversing

Language: Английский

Electroacupuncture inhibits oxidative stress and improves cognitive function by downregulating the Ang II/AT1R/NOX axis in chronic cerebral ischemia rats DOI

Qi Ai,

Jurui Wei,

Bijun Luo

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138179 - 138179

Published: Feb. 1, 2025

Language: Английский

Citations

0
Carnosol mitigates Ang II-stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation DOI

Yucheng Jiang,

Zhaozheng Zheng,

Junyi Wang

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
The gut microbiota in mice with erythropoietin—induced abdominal aortic aneurysm DOI Creative Commons
Xuanxin Lyu,

Ming Jiang,

Jiahao Shi

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19222 - e19222

Published: April 7, 2025

Background In recent years, a novel animal abdominal aortic aneurysm (AAA) model was established by administering erythropoietin (EPO) to wild-type (WT) mice. However, the influence of EPO on murine fecal microbiota remains uninvestigated. Therefore, this study aims explore potential association between gut changes and AAA development in model. Methods results Adult male C57BL/6 mice were used establish intraperitoneal administration recombinant human at dosage 10,000 IU/kg daily for 28 consecutive days. Hematoxylin eosin (H&E) Elastin Van Gieson (EVG) staining revealed that increased wall thickness diameter, accompanied enhanced degradation elastic lamina. The 16S rRNA—sequencing data deposited Sequence Read Archive (PRJNA1172300). LEfSe analysis Akkermansia, Lawsonibacter, Clostridium, Neglectibacter significantly associated with EPO-induced development, while Lactobacillus, Alistipes, Limosilactobacillus, Eisenbergiella showed significant negative correlations. Analysis using Kyoto Encyclopedia Genes Genomes (KEGG) prediction module differences metabolic pathways two groups, including alanine, aspartate glutamate metabolism; cysteine methionine pyrimidine carbon ABC transporters; oxidative phosphorylation pathways. Conclusions dysbiosis, particularly Alistipes abundance, may contribute formation via inflammation, stress, dysfunction. While advances research, its limitations underscore need validation mechanistic studies. Future work should prioritize multi-omics integration cross-model comparisons unravel complex microbiota-AAA axis.

Language: Английский

Citations

0
Exploring Angiotensin II and Oxidative Stress in Radiation-Induced Cataract Formation: Potential for Therapeutic Intervention DOI Creative Commons
Vidya P. Kumar,

Yali Kong,

Riana Dolland

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1207 - 1207

Published: Oct. 8, 2024

Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require deep understanding of the mechanisms underlying RIC formation (RICF). This study investigates roles angiotensin II (Ang II) oxidative stress in development, with focus on their combined effects lens transparency cellular function. Key include generation reactive oxygen species (ROS) damage proteins lipids, as well impact Ang inflammatory responses apoptosis. While ROS from water radiolysis is established, RICs less understood. intensifies by activating type 1 receptors (AT1Rs) epithelial cells, resulting increased production responses. leads protein aggregation, lipid peroxidation, apoptosis, ultimately compromising contributing cataract formation. Recent studies highlight II's dual role promoting both inflammation, which accelerates development. pose substantial concern due widespread prevalence quality life. Targeting signaling simultaneously could promising approach. Continued research necessary validate these explore efficacy preventing or reversing

Language: Английский

Citations

1