Childhood Experiences of Individuals Whose Parents are Schizophrenia Patients: A Phenomenological Study

International Journal of Systemic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: Feb. 10, 2025

Language: Английский

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Effects of Lee Silverman Voice Treatment‐BIG on Motor, Cognition, Mental Health, Occupational Performance, and Occupational Balance in Patients With Schizophrenia: A Single‐Subject Experimental Study

Occupational Therapy International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Introduction: In this study, we aim to apply BIG patients with schizophrenia confirm changes in mental symptoms, task performance, and occupational balance through motor cognitive enhancement. Method: This study used a single-subject A-B-A design. It consisted of total 22 sessions, 4 sessions the baseline period, 16 intervention period (Lee Silverman Voice Treatment-BIG), 2 follow-up period. The subjects were three male diagnosed chronic schizophrenia, all severe cases. During timed up go test (TUG) functional reach (FRT) Montreal Cognitive Assessment (MoCA) determine function cognition, subjective score (SS), Canadian Occupational Performance Measure (COPM), Balance Questionnaire-Korean (OBQ-K) psychiatric work satisfaction before after intervention. Statistically significant determined using two standard deviation (2SD) band method. Results: TUG, FRT, MoCA showed results compared SS, COPM, OBQ-K also positive scores from pre- postintervention. Conclusion: was found promote improvement patients, effects on satisfaction.

Language: Английский

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Protein palmitoylation: biological functions, disease, and therapeutic targets

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: Feb. 21, 2025

Abstract Protein palmitoylation, a reversible post‐translational lipid modification, is catalyzed by the ZDHHC family of palmitoyltransferases and reversed several acyl protein thioesterases, regulating localization, accumulation, secretion, function. Neurological disorders encompass spectrum diseases that affect both central peripheral nervous system. Recently, accumulating studies have revealed pathological associated with neurological diseases, such as β‐amyloid, α‐synuclein, Huntingtin, could undergo highlighting crucial roles palmitoylation in onset development diseases. However, few preclinical clinical trials focus on interventional strategies target palmitoylation. Here, we comprehensively reviewed emerging evidence role various summarized classification, processes, functions its impact stability, membrane protein–protein interaction, well signal transduction. Furthermore, also discussed potential targeting proteins elucidated their underlying pathogenic mechanisms Overall, an in‐depth understanding significances provide new avenues for investigating therapeutic approaches disorders.

Language: Английский

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ECT-induced primary open-angle glaucoma in a patient with unstable thyroid function: a case report

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

Schizophrenia is a prevalent and severe psychiatric disorder for which electroconvulsive therapy (ECT) frequently utilized as treatment modality. Although ECT can transiently elevate intraocular pressure, the incidence of ECT-related adverse ophthalmic events in patients with coexisting hyperthyroidism not well documented. In this report, we describe an elderly woman schizophrenia hyperthyroidism. Before undergoing ECT, she had no previous history glaucoma, her thyroid function was unstable state. After three sessions patient exhibited conjunctival congestion subsequently diagnosed primary open-angle treated. Her pressure normalized prior to following fourth session, experienced further ocular discomfort during subsequent treatments (fifth through eighth sessions). has been used dysfunction, there lack reports addressing risk inducing or exacerbating glaucoma context function. This case emphasizes necessity monitoring mitigate complications.

Language: Английский

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Current perspectives on the recognition and management of treatment-resistant schizophrenia: challenges and opportunities

Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Introduction Treatment-resistant schizophrenia (TRS) significantly impacts patients with schizophrenia, leading to a high disease burden, reduced quality of life, and functional impairment. Many fail respond standard antipsychotic treatments, requiring specialized therapeutic approaches. Clozapine remains the only approved treatment for TRS, demonstrating effectiveness in reducing symptoms, hospitalizations, risk suicide. However, its use is often delayed due concerns about adverse events, need ongoing monitoring.

Language: Английский

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Identification of biomarkers related to propionate metabolism in schizophrenia

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

Schizophrenia (SCZ) is a severe mental disorder with complex etiology. Research shows propionate metabolism crucial for neurological function and health. This suggests abnormalities in may link to SCZ. Therefore, identifying biomarkers associated might be beneficial the diagnosis treatment of SCZ patients. datasets metabolism-related genes (PMRGs) from public databases were obtained. DE-PMRGs identified through differential correlation analysis PMRGs. Machine learning was used screen key validate expression levels, aiming identify potential biomarkers. Gene Set Enrichment Analysis (GSEA) immune infiltration performed on An upstream regulatory network constructed, drugs targeting these explored. Finally, real-time fluorescence quantitative PCR (qPCR) verify biomarker levels. A total 11 identified, machine technology employed further 5 genes. Among these, LY96 TMEM123 emerged as verification. diagnostic model developed, achieving an area under curve (AUC) greater than 0.7, which indicates strong performance. Additionally, nomograms based demonstrated promising predictive capabilities assessing risk To explore gene functions mechanisms at deeper level, competitive endogenous RNA (ceRNA) including 2 biomarkers, 72 microRNAs, 202 long non-coding RNAs. In addition, containing 104 transcription factors (TFs) also established investigate interacting Potential biomarker-targeted by exploring DrugBank database; notably, exhibited higher binding affinities four drugs, docking scores consistently below-5 kcal/mol. The qPCR results indicated that levels whole blood patients significantly those healthy control group, consistent GSE38484 GSE27383 datasets. study disease SCZ, specifically TMEM123. These findings offer novel perspectives management

Language: Английский

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Epigenetics factors in schizophrenia: future directions for etiologic and therapeutic study approaches

Annals of General Psychiatry, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 4, 2025

Schizophrenia is a complex, heterogeneous, and highly disabling severe mental disorder whose pathogenesis has not yet been fully elucidated. Epigenetics, as bridge between genetic environmental factors, plays an important role in the pathophysiology of schizophrenia. Over past decade, epigenetic-wide association studies have rapidly become branch psychiatric research, especially deciphering molecular mechanisms This review systematically analyzes recent advances epigenome-wide (EWAS) schizophrenia, focusing on technological developments. We synthesize findings from large-scale EWAS alongside emerging evidence DNA methylation patterns, histone modifications, regulatory networks, emphasizing their roles disease treatment responses. In addition, this provides prospective outlook, evaluating impact that developments may future With continuous advancement high-throughput sequencing technology increasing maturity big data analysis methods, epigenetics expected to significant early diagnosis, prognosis assessment even personalized

Language: Английский

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Global research on cognitive function for Schizophrenia from 2014 to 2024: a bibliometric and visual analysis

Critical Public Health, Journal Year: 2025, Volume and Issue: 35(1)

Published: April 9, 2025

Language: Английский

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The roles of extracellular vesicles in mental disorders: information carriers, biomarkers, therapeutic agents

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Mental disorders are complex conditions that encompass various symptoms and types, affecting approximately 1 in 8 people globally. They place a significant burden on both families society as whole. So far, the etiology of mental remains poorly understood, making diagnosis treatment particularly challenging. Extracellular vesicles (EVs) nanoscale particles produced by cells released into extracellular space. contain bioactive molecules including nucleotides, proteins, lipids, metabolites, which can mediate intercellular communication involved physiological pathological processes. Recent studies have shown EVs closely linked to like schizophrenia, major depressive disorder, bipolar playing key role their development, diagnosis, prognosis, treatment. Therefore, based recent research findings, this paper aims describe roles summarize potential applications treatment, providing new ideas for future clinical transformation application EVs.

Language: Английский

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Association between elevated serum matrix metalloproteinase-2 and tumor necrosis factor-α, and clinical symptoms in male patients with treatment-resistant and chronic medicated schizophrenia

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 1, 2024

Inflammation has an important role in the pathogenesis of schizophrenia. The aim this study was to investigate levels tumor necrosis factor (TNF) and matrix metalloproteinase-2 (MMP-2) male patients with treatment-resistant schizophrenia (TRS) chronic medicated (CMS), relationship psychopathology.

Language: Английский

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