Prospects in Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
22(4), P. 146 - 154
Published: Dec. 27, 2024
Phenolic
molecules
are
secondary
metabolites
that
facilitate
several
biological
processes.
Secondary
non-nutritive
substances
hold
significant
medicinal
value.
Our
study
combined
the
activities,
general
features,
daily
usage
conditions,
and
biosynthesis
of
luteolin
as
reported
in
literature.
The
literature
review
revealed
exhibits
activities
including
antioxidant,
antibacterial,
anticancer,
anti-inflammatory
properties.
It
was
observed
it
exerts
effects
on
illnesses
cardioprotection,
cholesterol
regulation,
neuroprotection,
autistic
spectrum
disorders,
gastrointestinal
issues,
obesity,
insulin
sensitivity,
anxiety/depression,
arthritis.
In
this
regard,
identified
a
molecule
for
pharmacological
applications.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e18758 - e18758
Published: Jan. 22, 2025
Background
The
objective
of
the
present
study
is
to
examine
total
phenolic
and
flavonoid
content
an
ethanol
extract
Sanghuangporus
sanghuang
evaluate
its
phytochemical
properties,
antioxidant
activity,
capacity
protect
DNA
from
damage.
This
pharmaceutical/food
resource
mushroom
may
serve
as
a
novel
substitute
functional
food
for
health-conscious
consumers,
given
promising
source
phenolics
flavonoids.
Methods
S.
(SEE)
was
evaluated
contents,
while
UPLC-MS
analysis
used
terpenoids,
phenylpropanoid,
flavonoids,
steroidal,
phenols
identification,
function
prediction.
Antioxidant
anti-DNA
damage
activities
were
tested
in
vitro
using
ferric
reducing
power
(FRAP),
1,1-diphenyl-2-picrylhydrazyl
(DPPH),
2,2′-azino-bis-3-ethylbenzotiazolin-6-sulfonic
acid
(ABTS),
protection
assay.
Results
Conclusion
Total
(TPC)
SEE
385.38
±
1.36
mg
GA/g
extract,
(TFC)
298.22
2.38
QE/g
extract.
extracts
exhibited
high
free
radical
scavenging
with
relatively
stronger
activity.
A
491
metabolites
investigated
by
Ultra-performance
liquid
chromatography-mass
spectrometry
(UPLC-MS).
Most
top
20
compounds
predicted
have
various
functions
like
antioxidant,
anti-cancer
anti-inflammatory.
highlighted
beneficial
It
contains
potential
natural
that
could
be
lead
contender
development
medicines
treatment
wide
range
oxidative
stress-related
illnesses.
International Journal of Secondary Metabolite,
Journal Year:
2025,
Volume and Issue:
12(1), P. 188 - 203
Published: Jan. 19, 2025
Erigeron
bonariensis
L.
is
a
weed
belonging
to
the
Asteraceae
family
and
possesses
diverse
medicinal
properties.
It
known
have
therapeutic
uses,
including
infection
management
disease
treatment.
The
current
research
aims
investigate
pharmacological
phytochemical
properties
of
plant
extracts
(leaves
shoots).
A
thorough
examination
phytochemicals
was
carried
out
through
standardized
procedures,
quantitative
assessment
evaluated
spectral
analysis.
extract
subjected
investigation,
conclusively
establishing
its
potent
antioxidant
antimicrobial
activities.
activity
using
DPPH
(2,
2-diphenyl
1-picryl-hydrazyl)
scavenging
assay
NOSA
(Nitric
Oxide
scavenging)
assay,
while
determined
disc
diffusion
method.
screening
disclosed
presence
alkaloids,
sterols,
flavonoids,
tannins,
proteins,
fixed
oils
fats,
carbohydrates,
phenols,
glycosides,
saponins.
revealed
that
had
significant
capacity.
methanolic
leaf
exhibited
higher
efficacy
against
specific
varieties
Gram-negative
bacteria
(Escherichia
coli)
Gram-positive
(Bacillus
subtilis)
few
fungal
species
(Aspergillus
niger
Fusarium
oxysporum)
in
contrast
obtained
from
shoot,
as
evidenced
by
tests
conducted.
outcomes
indicate
leaves
bonariensis,
when
prepared
methanol,
show
greater
activities
than
shoots
do.
would
be
highly
beneficial
isolate
bioactive
compounds
responsible
for
natural
substances'
This
approach
can
facilitate
development
effective
treatments
various
health
conditions
future.
International Journal of Secondary Metabolite,
Journal Year:
2025,
Volume and Issue:
12(1), P. 46 - 53
Published: Jan. 19, 2025
Plants
are
vital
natural
resources
that
used
in
a
wide
range
of
applications.
Throughout
history,
these
tools
have
proven
to
be
valuable
assets
for
individuals.
We
conducted
study
assess
the
biological
activity
aerial
portions
Thalictrum
minus
L.
In
this
particular
situation,
plant's
ethanol
and
methanol
extracts
were
obtained
using
Soxhlet
equipment.
The
Rel
Assay
kits
measure
total
antioxidant
status
(TAS),
oxidant
(TOS),
oxidative
stress
index
(OSI).
antiproliferative
effectiveness
against
A549
lung
cancer
cell
line
was
assessed
MTT
test.
anticholinesterase
by
measuring
activities
acetylcholinesterase
butyrylcholinesterase.
analyzed,
their
TAS
values
determined
4.371±0.083
4.027±0.081,
respectively.
TOS
11.816±0.121
13.580±0.176,
respectively,
whereas
OSI
0.271±0.007
0.337±0.009.
extract
plant
found
greater
than
extract.
had
an
anti-AChE
value
58.90±1.41,
while
65.11±1.01.
Similarly,
anti-BChE
72.25±0.79,
85.79±0.68.
Consequently,
it
established
has
antioxidant,
anticancer,
properties.
BMC Biotechnology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 4, 2025
Algae
are
microscopic
or
macroscopic
organisms
that
can
photosynthesize
and
found
in
both
freshwater
saltwater
ecosystems
considered
one
of
the
cornerstones
life.
In
our
study,
biological
activities
extracts
produced
under
extract
conditions
provided
highest
activity
Ulva
lactuca
L.
were
determined.
Two
different
methods,
Response
Surface
Method
(RSM)
Artificial
Neural
Network-Genetic
Algorithm
(ANN-GA)
integration
used
for
optimization.
this
context,
optimum
determined
as
54.940
˚C
temperature,
6.513
h,
42.109
ethanol/water
ratio
according
to
RSM
method
56.286
7.2793
36.8625
ANN-GA.
The
antioxidant
optimized
evaluated
by
Rel
Assay
kits,
DPPH
FRAP
methods.
Anticholinesterase
testing
against
acetylcholinesterase
butyrylcholinesterase
enzymes.
addition,
antiproliferative
effects
examined
A549
lung
cancer
cell
line
phenolic
compound
contents
analyzed
LC-MS/MS.
As
a
result
analyzes,
it
was
seen
obtained
from
recommended
ANN-GA
exhibited
higher
activities.
Optimized
U.
have
potential
terms
total
value
6.272
±
0.024
mmol/L.
showed
strong
cytotoxic
line.
gallic
acid,
4-hydroxybenzoic
caffeic
vanillic
syringic
quercetin
kaempferol
algae
conditions.
detected
acid.
addition
all
these
properties,
has
anticholinesterase
study.
conclusion,
attract
attention
with
their
well
be
source
treatment
management
neurological
diseases.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 15, 2025
Abstract
In
this
study,
the
biological
activities
of
extracts
obtained
under
optimum
extraction
conditions
kernel
part
Juglans
regia
L.
were
determined.
Two
different
methods,
Response
Surface
Method
(RSM)
and
Artificial
Neural
Network-Genetic
Algorithm
(ANN-GA)
integration,
used
for
optimization.
The
antioxidant
capacity
extract
suggested
by
two
methods
was
evaluated
Rel
Assay
kits,
DPPH
FRAP
methods.
Anticholinesterase
optimized
measured
action
acetylcholinesterase
butyrylcholinesterase
enzymes.
Antiproliferative
effects
tested
on
A549
lung
cancer
cell
line.
Phenolic
compounds
analyzed
LC-MS/MS.
It
determined
that
both
exhibited
strong
against
line
depending
concentration
increase.
addition,
it
acetyl
inhibition
activity
close
to
galantamine
as
a
standard.
extracts,
13
including
gallic
acid,
catechinhyrate,
4-hydroxybenzoic
caffeic
vanillic
syringic
2-hydoxycinamic
resveratrol,
myricetin,
quercetin,
kaempferol,
protocatechuic
acid
2-hyroxy1,4
naphthaquinone
identified.
predicted
ANN-GA
higher
in
general.
Prospects in Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
23(2), P. 35 - 41
Published: April 29, 2025
In
this
study,
Silene
macrodonta
Boiss.
and
S.
chaetodonta
plant
species
belonging
to
the
Caryophyllaceae
family
growing
in
Gaziantep
region
were
examined
terms
of
antioxidant,
antimicrobial
phenolic
compounds.
Total
antioxidant
status
(TAS),
total
oxidant
(TOS)
oxidative
stress
index
(OSI)
values
determined
using
Rel
Assay
kits.
It
was
that
TAS
value
higher
with
5.983±0.156,
TOS
15.686±0.188,
OSI
0.341±0.010.
Within
scope
activity
by
Agar
dilution
method,
it
showed
than
macrodonta.
Phenolic
contents
plants
LC-MS/MS
device.
For
some
standards
used,
presence
compounds
detected.
As
a
result
studies,
have
high
biological
activity.
Prospects in Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
22(3), P. 69 - 75
Published: July 24, 2024
T
Today,
many
plant
species
come
to
the
fore
with
their
medicinal
potential.
Plants
are
medically
important
natural
resources.
In
our
study,
biological
activities
of
Equisetum
ramosissimum
were
determined.
Additionally,
total
phenolic
and
flavonoid
contents
measured.
The
aboveground
parts
extracted
ethanol
methanol.
Antioxidant
extracts
measured
Rel
Assay
TAS
TOS
kits.
Antimicrobial
activity
was
determined
against
test
bacteria
fungi
using
agar
dilution
method.
anticholinesterase
potential
(anti-AchE
anti-BchE)
by
measuring
acetyl-
butyrylcholinesterase
activities.
Total
content
Folin-Ciocalteu
reagent.
quantification
performed
aluminum
chloride
assay.
As
a
result
values
methanol
as
4.802±0.090
mmol/L
5.350±0.008
mmol/L,
respectively.
7.643±0.189
µmol/L
11.608±0.145
µmol/L,
OSI
0.159±0.005
0.217±0.006,
It
that
extract
effective
bacterial
strains
at
concentrations
50-400
µg/mL
fungal
50-200
µg/mL.
addition,
anti-AChE
20.45±0.54
16.70±0.43
µg/mL,
respectively,
anti-BChE
40.07±0.90
36.94±0.86
161.30±3.51
mg/g
199.11±1.96
mg/g,
119.00±1.60
103.61±2.39
mg/g.
result,
it
has
been
high
can
be
used
material
in
pharmacological
designs.
