Emerging risk factors for heart failure in younger populations: A growing public health concern

World Journal of Cardiology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 21, 2025

Heart failure (HF) is a growing public health concern, with an increasing incidence among younger populations. Traditionally, HF was considered condition primarily affecting the elderly, but of late, emerging evidence hints at rapidly rising in youth past 2 decades. has been linked to complex interaction between risk factors, such as metabolic syndrome, environmental exposures, genetic predispositions, and lifestyle behaviors. This review examines these evolving determinants, including substance abuse, autoimmune diseases, long-term cardiovascular effects coronavirus disease 2019, which disproportionately affect individuals. Through comprehensive analysis, study highlights importance early detection, targeted prevention strategies, multidisciplinary management approaches address this alarming trend. Promoting awareness integrating age-specific interventions could significantly reduce burden improve outcomes

Language: Английский

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Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS

Disease-a-Month, Journal Year: 2025, Volume and Issue: unknown, P. 101853 - 101853

Published: Jan. 1, 2025

Language: Английский

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Exploratory study on plasma Acylglycerol and Acylethanolamide dysregulation in substance use and attention-deficit/hyperactivity disorder: Implications for novel biomarkers in dual diagnosis

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111350 - 111350

Published: April 1, 2025

Substance use disorder (SUD) is a major global public health challenge, frequently co-occurring with psychiatric conditions such as attention-deficit/hyperactivity (ADHD). Endocannabinoid system (ECS) dysregulation has been implicated in both SUD and ADHD, but the interplay between these remains poorly understood. This study investigates plasma concentrations of endocannabinoid-congeners individuals SUD, without comorbid to identify potential biomarkers. exploratory included 469 participants divided into three groups: (1) healthy controls (n = 136), (2) patients ADHD 267), (3) 66). Plasma 12 endocannabinoid-related molecules, including acylglycerols (2-AG, 2-LG, 2-OG) acylethanolamides (AEA, DEA, DHEA, DGLEA, LEA, OEA, PEA, POEA, SEA), were quantified using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS). A multinomial Elastic Net regression model was applied assess their biomarker potential. Patients exhibited significantly lower 2-AG 2-LG compared controls, while most elevated, except for POEA SEA. comorbidity associated 2-AG, AEA, SEA, PEA elevated. Machine learning analysis identified SEA key biomarkers, achieving an accuracy 72.1 % ROC-AUC 0.77. suggests distinct ECS alterations highlighting Future research should validate findings larger cohorts explore ECS-targeted therapeutic interventions dual-diagnosis populations.

Language: Английский

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Positive allosteric modulation of glutamate transporter reduces cocaine-induced locomotion and expression of cocaine conditioned place preference in rats

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177017 - 177017

Published: Sept. 1, 2024

Language: Английский

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Substance use disorders and cooperative research on addictions: Spanish approach as a model

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107233 - 107233

Published: June 2, 2024

Substance use disorders (SUD), also named addiction when it is severe, a chronic brain disorder with serious impact on individual who suffer, the public health and high burden of disease. They are multitude mechanisms/factors involved in addiction: from characteristics person (from genetic to impacts stress, sex, age) social environmental situation (availability accessibility substances, cultural legal aspects, socio-economical situation) type substance (pharmacological characteristics) Then, research Addiction must include different, complementary, translational perspectives. In this review, we explore neurobiological, psychosocial, epidemiological knowledge addiction, main role played by pharmacology field. Spain, since 2002, collaborative networks have emerged for comprehensive addictions, creation Addictive Disorders Network (RTA), currently redefined as Research Primary Care Addictions (RIAPAd) support Carlos III Health Institute (Instituto de Salud III). Basic (including neuropharmacology behavioral pharmacology), clinical groups stand out, combining efforts address prevention, early detection treatment through interdisciplinary cooperation subsequent dissemination results.

Language: Английский

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Effect of N-acetylcysteine on craving in substance use disorders (SUD): a meta-analysis of randomized controlled trials

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 6, 2024

N-acetyl cysteine (NAC) appears promising as a treatment in patients with substance use disorder (SUD) it helps rebalance glutamate levels the central nervous system (CNS). Basal concentrations of are indeed reduced SUD but increased during craving.

Language: Английский

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