The impact of probiotics therapy on cognitive and metabolic characteristics in patients with cognitive impairment: An umbrella review of meta-analysis of randomized controlled trials

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177326 - 177326

Published: Feb. 1, 2025

While existing meta-analysis suggest that probiotic therapies may enhance cognitive functions and influence metabolic characteristics, the findings have been inconclusive. In light of these discrepancies, our study undertakes an umbrella review to more precisely determine aggregate effects rigorously evaluate credibility quality evidence. We conducted a systematic search across seven databases, including PubMed, Embase, Cochrane Library, ProQuest, Web Science, CINAHL, Scopus, from their inception June 20, 2024. utilized AMSTAR-2 tool meta-analyses applied GRADE system rate estimated final effect sizes (ES) along with 95% confidence intervals (CI) performed both sensitivity subgroup analyses explore sources heterogeneity. Among 314 articles identified in search, 13 met criteria were included study. The evidence studies was graded high very low. Our results demonstrate treatment significantly enhances function patients (ESSMD = 0.39, 95%CI: 0.19 0.59, p<0.001). Moreover, notably decreased level serum malondialdehyde (MDA), insulin resistance as detected by homeostasis model assessment method (HOMA-IR) high-sensitivity C-reactive protein (hs-CRP) (p<0.001). Conversely, did not impact triglycerides very-low-density lipoprotein (VLDL) (p>0.05). Although preliminary indicated therapy positively function, MDA, HOMA-IR, hs-CRP, overall is insufficient provide strong support. Therefore, future research must employ rigorous designs or initiate larger clinical trials produce compelling further validate efficacy on dysfunction.

Language: Английский

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in human body. Bacteria establish ecological niches various tissues of body, locally influencing their physiology functions, but also contributing to well‐being whole organism through systemic communication with other distant (axis). Emerging evidence indicates that when composition inhabiting niche changes toward a pathogenic state (dysbiosis) interactions become unbalanced, diseases may present. In addition, imbalances within single can cause dysbiosis organs. Current research efforts are focused on elucidating mechanisms leading dysbiosis, goal restoring tissue homeostasis. vitro models provide critical experimental platforms address this need, by reproducing cyto‐architecture high fidelity. This review surveys current host–microbiota strategies provides roadmap guide field further developing physiologically relevant niches, thus enabling investigation role health diseases. Lastly, given Food Drug Administration Modernization Act 2.0, highlights emerging support development validation new therapies market.

Language: Английский

Flavanones as Modulators of Gut Microbiota and Cognitive Function

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2203 - 2203

Published: May 18, 2025

Flavanones, a key subclass of flavonoids, exhibit wide range biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. Predominantly found in citrus fruits, they occur both aglycone glycosylated forms, undergoing extensive metabolic transformation upon ingestion. Recent evidence suggests that flavanones, such as naringenin hesperidin, influence gut microbiota composition, fostering balance between beneficial pathogenic bacterial populations. The plays pivotal role regulating the gut–brain axis, impacting cognitive function through production short-chain fatty acids (SCFAs), neurotransmitters, anti-inflammatory cytokines. modulation microbiome by flavanones has been associated with improvements performance reduced risk neurodegenerative disorders. This review provides comprehensive analysis characteristics major their pathways, impact on function. It covers fundamental mechanisms which exert effects, well potential therapeutic applications for brain health neuroprotection. Despite promising findings, further research is needed to determine optimal dosages, strategies enhance bioavailability, long-term safety profiles.

Language: Английский