CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis DOI Creative Commons
Zhongxue Feng, Lijun Wang, Yang Li

et al.

EMBO Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. However, how this dysregulation occurs remains be elucidated. In study, we use single-cell RNA sequencing (scRNA-seq) and conventional RNA-seq analyze the immune landscape of sepsis observe that adaptive immunity acutely strongly suppressed. This systemic immunosuppression not only in peripheral blood but also all other compartments, including spleen, lymph nodes, bone marrow. Clinical data show these immunity-related genes may have potential used distinguish patients with from those common infections. CD47 found play pivotal role inducing production amyloid-β (Aβ), which interacts CD74 on B cells, leading B-cell suppression subsequent immunosuppression. Blocking CD47-Aβ signaling significantly reduces injury improves survival rate septic mice restoring phagocytic cell functions alleviating

Language: Английский

CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis DOI Creative Commons
Zhongxue Feng, Lijun Wang, Yang Li

et al.

EMBO Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. However, how this dysregulation occurs remains be elucidated. In study, we use single-cell RNA sequencing (scRNA-seq) and conventional RNA-seq analyze the immune landscape of sepsis observe that adaptive immunity acutely strongly suppressed. This systemic immunosuppression not only in peripheral blood but also all other compartments, including spleen, lymph nodes, bone marrow. Clinical data show these immunity-related genes may have potential used distinguish patients with from those common infections. CD47 found play pivotal role inducing production amyloid-β (Aβ), which interacts CD74 on B cells, leading B-cell suppression subsequent immunosuppression. Blocking CD47-Aβ signaling significantly reduces injury improves survival rate septic mice restoring phagocytic cell functions alleviating

Language: Английский

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