Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metastatic colorectal carcinoma: a quasi-experimental study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

An exploration of the influence probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity prognosis in patients metastatic colorectal carcinoma. This was a quasi-experimental study. During March 2019 to 2020, 96 carcinoma were arbitrarily classified into control group (n = 48) intervention 48). The received only inhibitors or chemotherapy, while plus probiotic therapy. Survival complication rates after 6 months, 12 months 2 years treatment calculated. Intestinal barrier function quality life analyzed before treatment. Ninety-six recorded at follow-up demonstrating superior survival D-lactate diamine oxidase (DAO) levels elevated treatment, smaller elevations (P < 0.05). Bifidobacterium Lactobacillus remarkably higher compared prior following therapy amount Enterococcus Escherichia coli obviously lower pre-treatment groups CD3+, CD4+, CD4+/CD8+ found be 0.05), CD8+ reduced All dimensions QLQC-30 scale incidence complications such as nausea vomiting, loss appetite, bloating diarrhea considerably Immune regimens can enhance combination therapeutic strategy balance imbalanced flora, improve lessen adverse events, so it is worthy clinical application reactions.

Language: Английский

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Immuno-oncological Challenges and Chemoresistance in Veterinary Medicine: Probiotics as a New Strategic Tool

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

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Advances in understanding therapeutic mechanisms of probiotics in cancer management, with special emphasis on breast cancer: a comprehensive review

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177410 - 177410

Published: Feb. 1, 2025

Language: Английский

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Exploring the Impact of Chemotherapy on the Emergence of Antibiotic Resistance in the Gut Microbiota of Colorectal Cancer Patients

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 264 - 264

Published: March 5, 2025

With nearly half of colorectal cancer (CRC) patients diagnosed at advanced stages where surgery alone is insufficient, chemotherapy remains a cornerstone for this treatment. To prevent infections and improve outcomes, antibiotics are often co-administered. However, chemotherapeutic interactions with the gut microbiota cause significant non-selective toxicity, affecting not only tumor normal epithelial cells but also microbiota. This toxicity triggers bacterial SOS response loss microbial diversity, leading to mutations dysbiosis. Consequently, pathogenic overgrowth systemic increase, necessitating broad-spectrum intervention. review underscores how prolonged antibiotic use during chemotherapy, combined chemotherapy-induced mutations, creates selective pressures that drive de novo antimicrobial resistance (AMR), allowing resistant bacteria dominate gut. compromises treatment efficacy elevates mortality risk. Restoring diversity may mitigate therapeutic emerging strategies, such as fecal transplantation (FMT), probiotics, prebiotics, show considerable promise. Given global threat posed by treatment, prioritizing stewardship essential optimizing preventing in CRC undergoing chemotherapy. Future research should aim minimize chemotherapy’s impact on develop targeted interventions restore affected

Language: Английский

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Investigating the effectiveness of jackfruit (Artocarpus heterophyllus) substitution on fermentation dynamics and potential health benefits in Idli batter

Innovative Food Science & Emerging Technologies, Journal Year: 2024, Volume and Issue: unknown, P. 103900 - 103900

Published: Dec. 1, 2024

Language: Английский

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