Effects of Animal-Based and Plant-Based Nitrates and Nitrites on Human Health: Beyond Nitric Oxide Production

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 236 - 236

Published: Feb. 7, 2025

Nitrate (NO3) and nitrite (NO2) are important nitrogen compounds that play a vital role in the cycle, contributing to plant nutrition broader ecological functions. Nitrates produced from nitric acid (HNO3), while nitrites come nitrous (HNO2). These substances commonly found environment, especially food water, due contamination both human natural sources. Human activities major contributors high levels of nitrates leading environmental pollution. Although is crucial for growth, excessive fertilizer use has caused disruptions. In plants, tend accumulate primarily leaves non-leguminous crops, such as leafy vegetables, which known their nitrate content. Furthermore, added animal-based foods, processed meats cheeses, prevent bacterial slow spoilage, improve flavor color. The concentration these can vary different factors like farming practices, climate, soil conditions, production methods. This review seeks examine differences between plant-based sources assess potential impact on health, considering also paradigm goes beyond oxide production.

Language: Английский

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Integrated Assessment of Groundwater Quality Dynamics and Land Use/Land Cover Changes in Rapidly Urbanizing Semi-Arid Region

Environmental Research, Journal Year: 2024, Volume and Issue: 260, P. 119622 - 119622

Published: July 15, 2024

Language: Английский

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Nanonitrator: Novel nano-composite formulation of inorganic nitrate enhancing body protective effects

Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: 70(4-5), P. 460 - 462

Published: Feb. 1, 2025

Language: Английский

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Nitrate ameliorates myelin loss and cognitive impairment in Alzheimer’s disease through upregulation of neuronal sialin and subsequent inhibition of TPPP phosphorylation

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Nitrates and Nitrites in Leafy Vegetables: The Influence of Culinary Processing on Concentration Levels and Possible Impact on Health

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3018 - 3018

Published: March 26, 2025

Vegetables, as an important source of vitamins and minerals, are highly recommended in a healthy diet. At the same time, vegetables can contain elevated amounts nitrates nitrites, which possible nitrosating agents responsible for formation carcinogenic nitrosamines. In young children, they cause methemoglobinemia. Determining level well reduction their concentrations during culinary processing, is especially diet who introduced to leafy first year. For some types that often found diet, maximum permissible have not yet been established. Our goal was estimate factors nitrites suggest best ways properly prepare foods. this purpose, samples Swiss chard, spinach, white cabbage were collected from market determine nitrate nitrite content. Vegetable subjected preparations: soaking, cooking, combination soaking cooking. Quantitative qualitative determination carried out on high-performance liquid chromatography (HPLC) equipped with diode array detector (DAD). The obtained results showed highest chard samples, followed by lowest samples. impact preparation spinach Considering average achieved after cooking or there no risk exceeding ADI limit. However, values would be exceeded at concentrations.

Language: Английский

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Topical Application of Nitrate Ameliorates Skin Fibrosis by Regulating ST2+CD4+ T Cells in Systemic Sclerosis Mouse Model

Journal of Investigative Dermatology, Journal Year: 2024, Volume and Issue: 145(2), P. 346 - 358.e5

Published: June 28, 2024

Language: Английский

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Dietary nitrate attenuated oral submucous fibrosis via inhibiting PI3K/AKT signaling pathway

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Oral submucous fibrosis (OSF) is a potentially malignant disorder characterized by the accumulation of extracellular matrix in oral mucosa, which leads to stiffening and can result trismus. There still lack effective measures prevent treat OSF. Nitrate has been verified provide protective responses against fibrotic diseases multiple organs tissues. It remains unclear whether dietary nitrate In present study, we established OSF rat model evaluate effect for preventing treatment demonstrated promising preventive effects, including alleviation mucosal pallor, improved mouth opening, ameliorated histopathologic features rats with OSF, no side effects. Moreover, also inhibit collagen deposition, profibrogenic marker expression, inflammation. RNA-seq analysis tissues, followed functional verification, revealed that nitrate's primarily mediated through inhibition PI3K/AKT signaling pathway, ultimately leading reduced expression fibrosis-related markers. Our findings first time exhibited strong effects both vitro vivo models inhibiting pathway. Dietary supplementation could offer novel, safe, approach

Language: Английский

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BioCosMe: Lip-based Cosmetics with Colorimetric Biosensors for Salivary Analysis using Deep Learning

Published: Sept. 25, 2024

Language: Английский

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