Risk prediction for liver injury in Epstein-Barr virus infection in pediatric respiratory tract infections DOI Creative Commons
Song Mao,

Liangxia Wu,

Wenjing Shi

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2023, Volume and Issue: 49(1)

Published: Oct. 11, 2023

Epstein-Barr virus (EBV) infection is likely to co-occur in pediatric respiratory tract infections (RTIs). Liver injury the common complication of EBV infection. The detailed risk factors for liver remain elusive. We aimed investigate incidence, characteristics and potential early prediction.We retrospectively recruited RTIs cases with according a predefined criteria from our hospital between January 2015 December 2017. extracted clinical laboratory data electronical medical records. impact age, gender, various parameters on was investigated. Univariate logistic regression analysis performed analyse association clinical/laboratory injury. related indexes were enrolled multivariate analysis. Decision curve used yield value predicting Receiver operating (ROC) applied produce C-index white blood cell (WBC) count also tested non-linear WBC alanine aminotransferase (ALT).A total 216 enrolled. more occur during winter season. Cytomegalovirus independently associated (OR = 6.972, 95% CI 1.648-29.490, p 0.008). 1.169, 1.051-1.301, 0.004). P interaction cytomegalovirus 0.149. decision showed that had larger area under compared platelet (PLT) birthweight (BW). ROC yielded c-index count: 0.75 cut-point 8.3. turning point its ALT 16.8. before after < 0.001 0.123, respectively.Cytomegalovirus co-infection demonstrated 5.972 times an independent biomarker 16.8 More attention should be paid winter. merit monitoring possible among RTIs.

Language: Английский

Case report: emapalumab treatment for a pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patient with cytokine storm enabling allogeneic hematopoietic cell transplantation DOI Open Access

Wenguang Jia,

Xiaoqin Chen,

Jianming Luo

et al.

Translational Pediatrics, Journal Year: 2024, Volume and Issue: 13(4), P. 663 - 672

Published: April 1, 2024

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive immune activation and inflammatory response. Conventional immunotherapy molecular targeted drugs demonstrate varying efficacy. Cytokine storm, the primary pathogenic mechanism of HLH, driven interferon-gamma (IFN-γ), interleukin (IL)-2, IL-18, etc., in which IFN-γ plays critical role development disease. Emapalumab, potent inhibitor, effectively reduces occurrence cytokine storms refractory relapsed HLH.

Language: Английский

Citations

1
A predictive model for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis DOI Creative Commons
Rui Huang, Dan Wu, Ling Wang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 5, 2024

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a severe hyperinflammatory disorder induced by overactivation of macrophages and T cells. This study aims to identify the risk factors for progression from infectious mononucleosis (EBV-IM) EBV-HLH, analyzing laboratory parameters patients with EBV-IM EBV-HLH constructing clinical prediction model. The outcome this carries important value early diagnosis treatment EBV-HLH.

Language: Английский

Citations

1
Editorial introduction: Special issue on immunology, epidemiology, prevention, diagnosis, and treatment of pediatric infectious diseases and neglected tropical diseases DOI Creative Commons
Ran Wang, Qingjie Xue, Lingyun Guo

et al.

Infection Genetics and Evolution, Journal Year: 2024, Volume and Issue: 122, P. 105615 - 105615

Published: June 6, 2024

Language: Английский

Citations

0
The level of anti-viral antigen-specific antibodies to EBNA-1 in the serum of ms patients does not depend on the severity of the disease DOI
Leyla A. Ovchinnikova,

Samir S. Dzhelad,

Т. О. Simaniv

et al.

Доклады Российской академии наук Науки о жизни, Journal Year: 2024, Volume and Issue: 515(1), P. 92 - 96

Published: April 15, 2024

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease leading to inevitable disability and primarily affecting the young middle-aged population. Recent studies have shown a direct correlation between risk of MS development Epstein-Barr virus (EBV) infection. Analysis titer EBV-specific antibodies among patients with healthy donors Russian population confirmed that characterized by increased level serum IgG binding EBNA-1 (EBV nuclear antigen 1). The number elevated levels EBNA-1-specific does not differ statistically significantly two groups diametrically opposite courses MS: benign or highly active MS. It can be assumed primary link EBV restricted initiation impact its severity.

Language: Английский

Citations

0
The trend of Epstein-Barr virus DNA loads and CD8+ T lymphocyte numbers can predict the prognosis of pediatric liver transplant recipients with PTLD DOI Creative Commons
Kedi Wang, Dong-Jiang Xu,

Yan Gao

et al.

Journal of Laboratory Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract Objectives Epstein-Barr virus (EBV) can cause lymphoproliferative disorders (PTLD) in immunodeficiency individuals. The pathogenesis of EBV infection depends on its effective recognition and elimination. Our study investigated the effect peripheral lymphocyte subsets (PLS) elimination EBV. Methods A retrospective single-center included 63 patients with 17 pediatric liver transplant recipients EBV-induced PTLD (PTLD group) 46 diagnosed mononucleosis (IM group). Dynamic monitoring PLS EBV-DNA loads was performed. Results replicated at a high level (5.2E3∼5.93E7 copies/mL PBMC) before treatment all group. B lymphocytes were main infected cells. After Rituximab, decreased below lower limit detection 10 (PTLD-stable disease, PTLD-SD group), viral six (PTLD-partial response, PTLD-PR In group, percentage CD3 + CD8 T increased beyond normal range ascending loads, then it to accompanied by clearance kept range, while replication. Conclusions number occurred parallel decline which is most useful index estimating host capacity immuno-surveillance against

Language: Английский

Citations

0
Risk prediction for liver injury in Epstein-Barr virus infection in pediatric respiratory tract infections DOI Creative Commons
Song Mao,

Liangxia Wu,

Wenjing Shi

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2023, Volume and Issue: 49(1)

Published: Oct. 11, 2023

Epstein-Barr virus (EBV) infection is likely to co-occur in pediatric respiratory tract infections (RTIs). Liver injury the common complication of EBV infection. The detailed risk factors for liver remain elusive. We aimed investigate incidence, characteristics and potential early prediction.We retrospectively recruited RTIs cases with according a predefined criteria from our hospital between January 2015 December 2017. extracted clinical laboratory data electronical medical records. impact age, gender, various parameters on was investigated. Univariate logistic regression analysis performed analyse association clinical/laboratory injury. related indexes were enrolled multivariate analysis. Decision curve used yield value predicting Receiver operating (ROC) applied produce C-index white blood cell (WBC) count also tested non-linear WBC alanine aminotransferase (ALT).A total 216 enrolled. more occur during winter season. Cytomegalovirus independently associated (OR = 6.972, 95% CI 1.648-29.490, p 0.008). 1.169, 1.051-1.301, 0.004). P interaction cytomegalovirus 0.149. decision showed that had larger area under compared platelet (PLT) birthweight (BW). ROC yielded c-index count: 0.75 cut-point 8.3. turning point its ALT 16.8. before after < 0.001 0.123, respectively.Cytomegalovirus co-infection demonstrated 5.972 times an independent biomarker 16.8 More attention should be paid winter. merit monitoring possible among RTIs.

Language: Английский

Citations

1