Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon DOI Creative Commons
Maria Clara da Costa Barros, Jorge Estefano Santana de Souza, Daniel H. F. Gomes

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 9, 2024

Despite all the efforts acquired in four years of COVID-19 pandemic, path to a full understanding biological mechanisms involved this disease remains complex. This is partly due combination factors, including inherent characteristics infection, socio-environmental elements, and variations observed within both viral human genomes. Thus, study aimed investigate correlation between genetic host factors severity COVID-19. We conducted whole exome sequencing (WES) 124 patients, categorized into severe non-severe groups. From association analysis, variants (rs1770731 CRYBG1, rs7221209 DNAH17, rs3826295 DGKE, rs7913626 CFAP46) were identified as potentially linked protective effect against clinical COVID-19, which may explain less impact on Northern Region. Our findings underscore importance carrying out more genomic studies populations living Amazon, one most diverse from point view presence rare specific alleles. To our knowledge, first WES admixed individuals Brazilian Amazon associated with

Language: Английский

TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses DOI Creative Commons
Gilmara Barros de Lima,

Everton Nencioni,

Fábio Thimoteo

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 75 - 75

Published: Jan. 7, 2025

TMPRSS2, a human transmembrane protease enzyme, plays crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving glycoproteins, which helps viruses like SARS-CoV-2 A enter cells more effectively. Genetic differences TMPRSS2 may affect people’s susceptibility to COVID-19, underscoring need for studies that consider diverse populations. Beyond infectious diseases, has also been linked some cancers, suggesting it could be valuable target drug development. review provides summary inhibitors currently under study, with already clinical trials test their effectiveness against infections. As we uncover about TMPRSS2’s pathogenesis, open new doors therapies combat future outbreaks.

Language: Английский

Citations

0
Socioecology and Prevalence of SARS‐CoV‐2 Infection in Quilombolas Living in the Brazilian Amazon DOI Creative Commons
Keise Adrielle Santos Pereira, Lílian Natália Ferreira de Lima, Bruno José Sarmento Botelho

et al.

American Journal of Human Biology, Journal Year: 2025, Volume and Issue: 37(5)

Published: May 1, 2025

ABSTRACT Objectives This cross‐sectional study presents socioecological, epidemiological aspects, and the seroprevalence of immunoglobulin G (IgG) against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in a group quilombola (afro‐derived) communities states Pará Tocantins, Brazilian Amazon, to evaluate impact SARS‐CoV‐2 prevalence among them. Methods A total 551 individuals participated. The detection anti‐SARS‐CoV‐2 antibodies was performed using an enzyme immunoassay. Socioeconomic ecological data collected from all participants 7 years age or older who were not previously vaccinated. Results both 40.7% associated with factors such as group, contact infected individuals, being lockdown inside quilombos . In Pará, statistically significant association observed between females, 12–18 years. addition, higher than reported use masks protective factor, while presence antibodies. There no COVID‐19 symptoms Pará. However, diarrhea loss taste infection. Conclusions Quilombola are highly vulnerable groups due long history enslavement Brazil. is first investigation its these Amazon. helps us understand relationship socioecological differences, behavioral characteristics, dynamics viral transmission risk infection by traditional populations, can be useful planning more culturally adequate public health policies for future epidemics.

Language: Английский

Citations

0
Polymorphisms in the ACE I/D (rs4646994) and ACE2 G8790A (rs2285666) in Young Children Living in the Amazon Region and SARS-CoV-2 Infection DOI Creative Commons
Yan Cardoso Pimenta, Flávia Freitas de Oliveira Bonfim, Carlos Eduardo da Silva Figueiredo

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(11), P. 270 - 270

Published: Nov. 7, 2024

COVID-19 infection caused by SARS-CoV-2 continues to cause significant mortality and morbidity. ACE2 is a key regulator of the renin-angiotensin-aldosterone system (RAAS). Differences in severity are thought be due imbalance RAAS/ACE mutations. This retrospective study evaluated detection genetic susceptibility 202 children ≤3 years age living Amazon region 2021. The angiotensin-converting enzyme ACE I/D (

Language: Английский

Citations

0
Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon DOI Creative Commons
Maria Clara da Costa Barros, Jorge Estefano Santana de Souza, Daniel H. F. Gomes

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 9, 2024

Despite all the efforts acquired in four years of COVID-19 pandemic, path to a full understanding biological mechanisms involved this disease remains complex. This is partly due combination factors, including inherent characteristics infection, socio-environmental elements, and variations observed within both viral human genomes. Thus, study aimed investigate correlation between genetic host factors severity COVID-19. We conducted whole exome sequencing (WES) 124 patients, categorized into severe non-severe groups. From association analysis, variants (rs1770731 CRYBG1, rs7221209 DNAH17, rs3826295 DGKE, rs7913626 CFAP46) were identified as potentially linked protective effect against clinical COVID-19, which may explain less impact on Northern Region. Our findings underscore importance carrying out more genomic studies populations living Amazon, one most diverse from point view presence rare specific alleles. To our knowledge, first WES admixed individuals Brazilian Amazon associated with

Language: Английский

Citations

0