The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(22), P. 5615 - 5615

Published: Nov. 10, 2019

The etiopathogenesis of endometriosis is a multifactorial process resulting in heterogeneous disease. Considering that etiology and pathogenesis are still far from being fully elucidated, the current review aims to offer comprehensive summary available evidence. We performed narrative synthesizing findings English literature retrieved computerized databases inception June 2019, using Medical Subject Headings (MeSH) unique ID term “Endometriosis” (ID:D004715) with “Etiology” (ID:Q000209), “Immunology” (ID:Q000276), “Genetics” (ID:D005823) “Epigenesis, Genetic” (ID:D044127). Endometriosis may origin Müllerian or non-Müllerian stem cells including those endometrial basal layer, remnants, bone marrow, peritoneum. innate ability regenerate cyclically seems play key role, as well dysregulated hormonal pathways. presence such peritoneal cavity what leads development complex large number interconnected factors, potentially both inherited acquired. Genetic predisposition related combined action several genes limited influence. epigenetic mechanisms control many processes involved immunologic, immunohistochemical, histological, biological aberrations characterize eutopic ectopic endometrium affected patients. However, triggers alterations not clear be genetically epigenetically inherited, it acquired by particular combination elements persistent menstrual reflux exogenous factors. heterogeneity different contexts which develops suggest single etiopathogenetic model sufficient explain its pathobiology.

Language: Английский

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Pathogenesis of endometriosis: the genetic/epigenetic theory

Fertility and Sterility, Journal Year: 2018, Volume and Issue: 111(2), P. 327 - 340

Published: Dec. 7, 2018

Language: Английский

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The Burden of Endometriosis on Women’s Lifespan: A Narrative Overview on Quality of Life and Psychosocial Wellbeing

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(13), P. 4683 - 4683

Published: June 29, 2020

Endometriosis is a chronic, inflammatory disease affecting more than 170 million women worldwide and up to 10% of reproductive age. As consequence reaction infiltration anatomic structures, endometriosis can cause “pain symptoms” including dysmenorrhea, dyspareunia, dyschezia, dysuria, chronic pelvic pain. In this review, we summarized the impact on quality life in all its aspects sexual life, work, social relationships. The data research was conducted using web-based search engines and/or various electronic databases querying for articles related from inception database February 2020. has not only physical but also psychological effects, causing depression, anxiety, compromising Furthermore, negatively impacts At last, economic burden should be underestimated, both individually community, as pathology leads loss productivity at work large use health resources. Thus, endometriosis-related symptoms control women’s lives aspects. lives.

Language: Английский

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Pathogenesis of deep endometriosis

Fertility and Sterility, Journal Year: 2017, Volume and Issue: 108(6), P. 872 - 885.e1

Published: Nov. 1, 2017

Language: Английский

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Iron Deficiency Anemia in Pregnancy: Novel Approaches for an Old Problem

Oman Medical Journal, Journal Year: 2020, Volume and Issue: 35(5), P. e166 - e166

Published: Sept. 8, 2020

Iron needs increase exponentially during pregnancy to meet the increased demands of fetoplacental unit, expand maternal erythrocyte mass, and compensate for iron loss at delivery. In more than 80% countries in world, prevalence anemia is > 20% could be considered a major public health problem. The global estimated approximately 41.8%. Undiagnosed untreated deficiency (IDA) can have great impact on fetal health. Indeed, chronic affect general wellbeing mother leads fatigue reduced working capacity. Given significant adverse maternal-fetal outcomes, early recognition treatment this clinical condition fundamental. Therefore, laboratory assays are recommended from first trimester evaluate status. Oral supplementation line cases mild anemia. However, considering numerous gastrointestinal side effects that often lead poor compliance, other therapeutic strategies should evaluated. This review aims provide an overview current evidence about management IDA available options.

Language: Английский

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Impact of Endometriosis on Life-Course Potential: A Narrative Review

International Journal of General Medicine, Journal Year: 2021, Volume and Issue: Volume 14, P. 9 - 25

Published: Jan. 1, 2021

Endometriosis may exert a profound negative influence on the lives of individuals with disorder, adversely affecting quality life, participation in daily and social activities, physical sexual functioning, relationships, educational work productivity, mental health, well-being. Over course lifetime, these challenges translate into limitations achieving life goals such as pursuing or completing opportunities; making career choices advancing chosen career; forming stable, fulfilling relationships; starting family, all which ultimately alter one's trajectory. The potential for endometriosis to impact is considerable, symptom onset generally occurs at time (menarche through menopause, adolescence middle age) when multiple life-changing trajectory-defining decisions are made. Using life-course approach, we examine how known effects life-domain satisfaction health well-being across affected individuals. We provide quasi-systematic, narrative review literature well expert opinion recommendations clinical management future research directions.

Language: Английский

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Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(5), P. 1750 - 1750

Published: March 4, 2020

Background: Early and accurate diagnosis of endometriosis is crucial for the management this benign, yet debilitating pathology. Despite advances modern medicine, there no common ground regarding pathophysiology disease as it continues to affect quality life millions women reproductive age. The lack specific symptoms often determines a belated diagnosis. gold standard remains invasive, surgery followed by histopathological exam. A biomarker or panel biomarkers easy measure, usually noninvasive, could benefit clinician in both diagnosing monitoring treatment response. Several studies have advanced idea endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing results these search promising perspectives on early Methods: We selected papers from Google Academic, PubMed, CrossRef reviewed recent articles literature, aiming evaluate effectiveness various putative serum urinary endometriosis. Results: majority focused biomarkers, rather than single were unable identify biomolecule with sufficient specificity sensitivity Conclusion: Noninvasive proteomics, genomics, miRNA microarray may aid diagnosis, but further research larger datasets along better understanding pathophysiologic mechanisms are needed.

Language: Английский

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Anti-inflammatory cytokines in endometriosis

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 76(11), P. 2111 - 2132

Published: March 2, 2019

Language: Английский

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Diagnostic delay for superficial and deep endometriosis in the United Kingdom

Journal of Obstetrics and Gynaecology, Journal Year: 2019, Volume and Issue: 40(1), P. 83 - 89

Published: July 22, 2019

A Cross-sectional study was undertaken at a specialist centre in the United Kingdom investigating duration and causes of delay diagnosis endometriosis. One hundred one women completed self-reported questionnaire containing 20 items about their psychosocial, symptoms experiences. The statistical analysis included Mann-Whitney U test. p value .05 considered statistically significant. Spearman's rank correlation also calculated. Overall, there median 8 years (Q1–Q3: 3–14) from onset to Factors such as menstrual cramps adolescence, presence rectovaginal endometriosis, normalisation pain attitudes health professionals contributed delayed (p values<.05). There negative indicating earlier symptoms, greater (Spearman's Rank Correlation Coefficient –0.63, p<.01). results this highlight considerable diagnostic associated with endometriosis need for clinician education public awareness.Impact statementWhat is already known on subject? 7–9 has been reported globally. In an effort standardise surgical treatment, improve outcomes, shorten delays centres were introduced 2011. no recent quality improvement assessment since establishment centres.What do add? This most evaluation introduction centres. years. seem not have improved over last two decades. We identified medical psychosocial factors that may contribute delays. These include diagnosis.What are implications these findings clinical practice and/or further research? study, awareness decrease long term-morbidity complications result untreated

Language: Английский

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Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 10

Published: Jan. 29, 2020

Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue (glands and stroma) outside uterus, mainly in peritoneal cavity, ovaries, intestines. This condition shows estrogen dependency progesterone resistance, it has been associated with chronic inflammation, severe pain, infertility, which negatively affect quality life reproductive-age women. The molecular mechanisms involved pathogenesis endometriosis are not completely understood, however, inflammation plays key role pathophysiology disease, altering function immune cells (macrophages, T cells, natural killer ) increasing levels pro-inflammatory mediators endometrium, blood. These alterations, inhibit apoptotic pathways promote adhesion proliferation endometriotic as well angiogenesis neurogenesis lesions. It demonstrated that hormonal alterations related to inflammatory unbalance this disease. Particularly, steroid hormones (mainly estradiol) expression release factors. In turn, excessive observed contributes resistance high sensitivity modulating sex receptors aromatase activity. addition, dysregulation inflammasome pathway, mediated an alteration cellular responses hormones, participates disease progression through preventing cell death, promoting adhesion, invasion, Furthermore, endometriosis-associated due response mounted alters their receptivity impairing biochemical decidualization. purpose review present overview current research about clarify probable

Language: Английский

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