A sustainable approach to derive sheep corneal scaffolds from stored slaughterhouse waste
Regenerative Medicine,
Journal Year:
2024,
Volume and Issue:
19(6), P. 303 - 315
Published: June 2, 2024
The
escalating
demand
for
corneal
transplants
significantly
surpasses
the
available
supply.
To
bridge
this
gap,
we
concentrated
on
ethical
and
sustainable
grafting
sources.
Our
objective
was
to
create
viable
scaffolds
from
preserved
slaughterhouse
waste.
Language: Английский
Transforming meat waste into sustainable corneal keratoplasty models
Ayman Mobin,
No information about this author
Zayd Hashem,
No information about this author
Peter R. Corridon
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et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 14, 2025
With
a
rapidly
global
population,
there
is
critical
need
to
enhance
food
production
and
waste
management.
This
necessity
driving
opportunities
for
sustainable
integrated
chains
committed
biovalorization
circular
bioeconomic
practices.
One
approach
that
aligns
with
this
vision
relies
on
tissue
engineering,
which
offers
leverage
systems
in
the
search
natural
biomaterials
from
agricultural
waste.
In
perspective,
we
propose
utilizing
common
meat
sources,
often
associated
high
environmental
footprint,
develop
graft
models.
These
models
reduce
waste,
decrease
reliance
animal
testing,
support
both
medical
innovation.
Specifically,
explore
unique
generate
corneal
transplantation
completely
discarded
components
of
chain,
using
eyes
bladders.
strategy
involves
creating
keratoplasty
by
reseeding
decellularized
extracellular
matrix
(dECM),
encompassing
three
major
regions:
epithelium,
stroma,
endothelium.
Interestingly,
these
scaffolds
can
be
recellularized
cellular
lineages
derived
stem
niches
harvested
urine.
integrates
management
regenerative
medicine,
fostering
advancements
engineering.
Language: Английский
Integrated environmental and health economic assessments of novel xeno-keratografts addressing a growing public health crisis
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 27, 2024
Tissue
scarcity
poses
global
challenges
for
corneal
transplantation
and
public
health.
Xeno-keratoplasty
using
animal-derived
tissues
offers
a
potential
solution,
but
its
environmental
economic
implications
remain
unclear.
This
study
evaluated
two
xeno-keratoplasty
procedures
at
single
institution:
(1)
native
corneas
(Option
1)
(2)
tissue-engineered
scaffolds
derived
from
slaughterhouse
waste
2).
Life
cycle
assessment
(LCA)
quantified
impacts
across
18
midpoint
indicators,
while
cost-effectiveness
analysis
(CEA)
incorporated
cost
impact
approaches.
Option
1
exhibited
significantly
lower
than
2
most
primarily
due
to
the
energy
equipment
demands
of
cell
culture
in
2.
Both
CEA
approaches
(carbon
offset
pricing
utility
decrement)
demonstrated
dominance
1.
appears
more
environmentally
economically
favorable
2)
current
analysis.
Future
studies
could
explore
diverse
techniques
optimizing
sustainability.
Language: Английский
Sustainable varicose vein therapy using functionalized hydrogels derived solely from livestock waste
Frontiers in Sustainable Food Systems,
Journal Year:
2024,
Volume and Issue:
8
Published: Aug. 7, 2024
Developing
sustainable
and
effective
treatments
for
chronic
venous
insufficiency
(CVI)
is
crucial.
In
this
study,
we
propose
an
innovative
restorative
approach
utilizing
hydrogels
derived
from
the
decellularized
extracellular
matrix
(dECM)
of
cadaveric
vascular
tissues,
adipose-derived
stem
cells
(ADSCs),
gold
nanoparticles
(AuNPs).
This
therapeutic
method
leverages
waste
valorization
by
repurposing
discarded
tissues
slaughterhouse
livestock.
The
dECM
hydrogels,
enriched
with
ADSCs
AuNPs,
offer
a
biocompatible
scaffold
that
supports
cellular
differentiation
integrity.
Our
addresses
limitations
current
allo-,
auto-,
xenograft
methods
enhancing
integration
functionality
while
potentially
reducing
costs
through
practices.
study
explores
functionalized
hydrogel
formulation
solely
generated
agri-food
waste,
gelation
mechanisms,
preliminary
cost-effectiveness,
presenting
promising
new
avenue
treating
early-stage
varicose
veins
can
ultimately
be
translated
to
human
models
using
tissues.
Language: Английский
Investigation of Fatty Acid Profile of Eyes Recovered from Slaughterhouse Waste
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(18), P. e38148 - e38148
Published: Sept. 1, 2024
Polyunsaturated
fatty
acids
(PUFAs),
principally
Docosahexaenoic
acid
(DHA,
22:6n-3),
the
foremost
omega-3
PUFAs
in
brain
and
eyes,
have
been
implicated
maintaining
structural
functional
properties
of
retina
cornea.
Another
PUFA,
Arachidonic
Acid
(AA,
20:4n-6),
primary
omega-6
PUFA
cell
membrane
phospholipids,
is
a
central
inflammatory
mediator
involved
many
molecular
cellular
functions
under
physiological
pathological
conditions,
including
dry
eye
disease
(DED)
age-related
macular
degeneration
(AMD).
This
study
investigated
(FA)
composition
vitreous
humor,
retina,
cornea,
whole
two
mammals,
Arabian
sheep
(
Language: Английский