Rhodium Catalysts Based on Phenyl Substituted Cp Ligands for Indole Synthesis via Oxidative Coupling of Acetanilides and Alkynes

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(22), P. 4729 - 4736

Published: Aug. 16, 2024

Abstract Rhodium‐catalyzed oxidative coupling of acetanilides and alkynes via C−H activation is the most powerful synthetic tool for producing indole motif from commercially available precursors. However, this reaction usually requires large catalyst loadings (5 mol% rhodium). In study, a 1,2‐diphenylcyclopentadienyl ligand‐based was developed that works well at 1 loading rhodium. DFT calculations step provided insight into its high catalytic activity. The efficiency also demonstrated in synthesis naturally occurring isocoumarins, such as polygonolide, tubakialactone B penicimarine F. protocols tolerate wide range functional groups, example, halide, nitro, hydroxy, alkoxy.

Language: Английский

Available strategies for the synthesis of indenes for metal complex catalysis

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(10), P. 2787 - 2800

Published: Oct. 1, 2024

Language: Английский