Advances in Host–Pathogen Interactions in Tuberculosis: Emerging Strategies for Therapeutic Intervention
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1621 - 1621
Published: Feb. 14, 2025
Tuberculosis
(TB)
remains
one
of
the
most
challenging
infectious
diseases,
with
Mycobacterium
tuberculosis
(Mtb)
employing
sophisticated
mechanisms
to
evade
host
immunity
and
establish
persistent
infections.
This
review
explores
recent
advances
in
understanding
Mtb's
immune
evasion
strategies;
granuloma
dynamics;
emerging
immunotherapeutic
approaches.
Key
findings
highlight
manipulation
autophagy;
metabolic
reprogramming;
cytokine
pathways
by
Mtb
sustain
its
survival
within
cells.
Insights
into
formation
reveal
critical
role
bacterial
lipids;
modulation;
hypoxia-driven
dormancy
maintaining
chronic
infection.
Innovative
therapeutic
strategies,
including
host-directed
therapies;
epigenetic
interventions;
immunomodulators,
hold
promise
for
improving
TB
management
combating
drug-resistant
strains.
Despite
these
advancements,
significant
challenges
remain,
development
effective
vaccines;
addressing
latent
TB;
ensuring
equitable
access
novel
treatments.
The
integration
advanced
technologies
such
as
artificial
intelligence
multi-omics
approaches,
alongside
global
collaboration,
is
essential
overcome
hurdles.
underscores
importance
a
multidisciplinary
approach
tackling
TB,
ultimate
goal
eradicating
this
health
threat.
Language: Английский
Advancing personalized medicine: Integrating statistical algorithms with omics and nano-omics for enhanced diagnostic accuracy and treatment efficacy
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Journal Year:
2024,
Volume and Issue:
1870(7), P. 167339 - 167339
Published: Oct. 1, 2024
Language: Английский
Advancing Precision Medicine: Uncovering Biomarkers and Strategies to Mitigate Immune-Related Adverse Events in Immune Checkpoint Inhibitors Therapy
K L Nityashree,
No information about this author
P. Rachitha,
No information about this author
Shilpa Hanchinmane
No information about this author
et al.
Toxicology Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102035 - 102035
Published: April 1, 2025
Language: Английский
Innovative strategies in the fight against bacterial infections: Phage therapy, nanotechnology, and new antimicrobial agents for multidrug-resistant pathogens
Results in Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102304 - 102304
Published: April 1, 2025
Language: Английский
Model systems to study Mycobacterium tuberculosis infections: an overview of scientific potential and impediments
Prachi Nangpal,
No information about this author
Neha Nagpal,
No information about this author
Nupur Angrish
No information about this author
et al.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: May 8, 2025
Despite
years
of
global
efforts
to
combat
tuberculosis
(TB),
Mycobacterium
(Mtb),
the
causative
agent
this
disease,
continues
haunt
humankind
making
TB
elimination
a
distant
task.
To
comprehend
pathogenic
nuances
organism,
various
in
vitro,
ex
vivo
and
experimental
models
have
been
employed
by
researchers.
This
review
focuses
on
salient
features
as
well
pros
cons
model
systems
for
research.
In
vitro
macrophage
infection
extensively
used
studying
Mtb
physiology.
Animal
provided
us
with
great
wealth
information
immensely
contributed
understanding
pathogenesis
host
responses
during
infection.
Additionally,
they
evaluation
anti-mycobacterial
drug
therapy
determining
efficacy
potential
vaccine
candidates.
Advancements
'omics'
based
approaches
enhanced
our
about
host-pathogen
interface.
Although
animal
cornerstone
research,
none
them
is
ideal
that
gives
complete
picture
human
infection,
disease
progression.
Further,
also
discusses
newer
including
three
dimensional
(3D)-tissue
models,
lung-on-chip
model,
granuloma
their
limitations
TB.
Thus,
converging
gained
from
tandem
experiments
will
ultimately
bridge
gap
exists
Language: Английский
Precision medicine and personalized treatment
Elsevier eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 151 - 174
Published: Jan. 1, 2025
Language: Английский
Viewpoint of multi-omics potential in tuberculosis research: identifying biomarkers for biomanufacturing of efficient control tools
Frontiers in Tropical Diseases,
Journal Year:
2024,
Volume and Issue:
5
Published: July 31, 2024
Tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis
complex
(MTBC),
remains
a
global
health
burden,
claiming
millions
of
lives
annually.
Despite
the
availability
vaccine
(the
Bacillus
Calmette-Guérin;
BCG),
diagnostics
(smear
microscopy
and
DNA-based
diagnostics)
drugs
for
treatment,
challenges
like
drug
resistance,
lower
diagnostic
sensitivity
such
as
microscopy,
instrumentation
high-level
operational
expertise
requirement
poor
efficacy
pose
greater
hinderance
to
TB
monitoring
control.
The
inability
BCG
protect
against
other
than
disseminated
disease
in
neonates
call
innovative
approaches
provide
improved
interventions.
This
review
highlights
potential
multi-omics
powerful
emerging
tool
offering
holistic
insight
into
intricate
interplay
between
pathogens
host
immune
response.
It
discusses
discovering
biomarkers
targets
rational
design,
production
more
effective
vaccines
stable
universally
applicable
rapid
early
accurate
detection
well
treatment.
Language: Английский