Biochemistry and laboratory diagnosis of obesity DOI Creative Commons
Neda Milinković, Nataša Bogavac‐Stanojević, Jelena Vekić

et al.

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(3), P. 348 - 374

Published: Jan. 1, 2024

Until now, a lot of research has been carried out which significantly helped in understanding and solving the problem obesity. Despite this, there an upward obesity trend at global level. The role laboratory diagnostics field is great importance to doctors for establishing diagnosis monitoring effects therapy. Determining biochemical parameters also contributes practical usefulness prevention this disease, consequent complications. Routinely available analyses are usually used diagnose monitor initial association related refers lipid status, but variety routine that can help from different angles. Timely adequate management interest economic aspect. For reason, topic summarize latest aspects concept obesity, specifically point view biochemistry diagnostics. Taking into account complexity it important future perspectives challenges inevitably arise before both professionals healthcare providers general.

Language: Английский

Obesity, Metabolic Syndrome, and Osteoarthritis—An Updated Review DOI
Samuel Joshua Pragasam Sampath, Vijayalakshmi Venkatesan, Sudip Ghosh

et al.

Current Obesity Reports, Journal Year: 2023, Volume and Issue: 12(3), P. 308 - 331

Published: Aug. 14, 2023

Language: Английский

Citations

60
Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism DOI Creative Commons
Liyi Wang, Teresa G. Valencak, Tizhong Shan

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109221 - 109221

Published: Feb. 15, 2024

Fat infiltration in skeletal muscle (also known as myosteatosis) is now recognized a distinct disease from sarcopenia and directly related to declining capacity. Hence, understanding the origins regulatory mechanisms of fat vital for maintaining development improving human health. In this article, we summarized triggering factors such aging, metabolic diseases syndromes, nonmetabolic diseases, injury that all induce muscle. We discussed recent advances on cellular found several cell types including myogenic cells non-myogenic contribute myosteatosis. Furthermore, reviewed molecular mechanism, detection methods, intervention strategies Based current findings, our review will provide new insight into regulating function lipid metabolism treating muscle-related diseases.

Language: Английский

Citations

39
The Metabolic Syndrome, a Human Disease DOI Open Access
M. Alemany

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

Citations

30
Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease DOI Open Access
Michihiro Iwaki, Takashi Kobayashi, Asako Nogami

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 891 - 891

Published: Feb. 10, 2023

With the increasing incidence of non-alcoholic fatty liver disease (NAFLD) and aging population, sarcopenia is attracting attention as one pathological conditions involved in development progression NAFLD. In NAFLD, closely associated with insulin resistance results from atrophy skeletal muscle, an target organ. addition, inflammatory cytokines that promote muscle protein breakdown, low adiponectin levels leading to decreased sensitivity, hyperleptinemia are also NAFLD pathogenesis. The presence a prognostic factor increases risk mortality patients cirrhosis post-treatment cancer. Sarcopenia, which mainly occurs due mass, combined increased visceral fat, can lead sarcopenia-associated obesity, NASH, fibrosis, cardiovascular disease. order treat sarcopenia, it necessary properly evaluate status. Patients high BMI, sarcopenic may improve caloric restriction. However, inadequate oral intake further loss mass. Aerobic exercise should be used appropriately.

Language: Английский

Citations

35
Adipose tissue in older individuals: a contributing factor to sarcopenia DOI
Tiantian Wang, Dongmei Zhou, Zhen Hong

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 160, P. 155998 - 155998

Published: Aug. 10, 2024

Language: Английский

Citations

10
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions DOI Creative Commons
Tiantian Wang, Dong Zhou, Zhen Hong

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract Sarcopenia is defined as a muscle‐wasting syndrome that occurs with accelerated aging, while cachexia severe wasting associated conditions such cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. can considered component of cachexia, the bidirectional interplay between adipose tissue skeletal muscle potentially serving molecular mechanism for both conditions. However, underlying mechanisms differ. Recognizing distinctions these disorders essential advancing basic translational research in this area, enhancing diagnostic accuracy ultimately achieving effective therapeutic solutions affected patients. This review discusses microenvironment's changes contributing to conditions, recent approaches like lifestyle modifications, small molecules, interventions, emerging strategies gene editing, stem cell therapy, gut microbiome modulation. We also address challenges opportunities multimodal aiming provide insights into pathogenesis sarcopenia aiding innovative strategy development improved treatments.

Language: Английский

Citations

1
Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C DOI
Yang Li, Ruo-Ying Li,

Jieying Zhu

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis DOI Creative Commons
Yanqiu Peng, Lixia Zhao, Min Li

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 483 - 483

Published: April 16, 2024

Obesity, characterized by the excessive accumulation of adipose tissue, has emerged as a major public health concern worldwide. To develop effective strategies for treating obesity, it is essential to comprehend biological properties different tissue types and their respective roles in maintaining energy balance. Adipose serves crucial organ storage metabolism human body, with functions extending beyond simple fat encompass regulation homeostasis secretion endocrine factors. This review provides an overview key characteristics, functional differences, interconversion processes among white (WAT), brown (BAT), beige tissue. Moreover, delves into molecular mechanisms recent research advancements concerning browning WAT, activation BAT, whitening BAT. Although targeting holds promise potential approach obesity treatment, further investigations are necessary unravel intricate features various elucidate pathways governing interconversion. Such endeavors will pave way development more efficient targeted therapeutic interventions fight against obesity.

Language: Английский

Citations

6
The impacts of obesity in rheumatoid arthritis and insights into therapeutic purinergic modulation DOI
Geórgia de Carvalho Braga, Júlia Leão Batista Simões,

Yara Juarez Teixeira dos Santos

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112357 - 112357

Published: May 27, 2024

Language: Английский

Citations

4
Thermal-crosslinked acellular dermal matrix combined with adipose-derived stem cells to regenerate vascularized adipose tissue DOI Creative Commons
Xing Huang, Siyuan Chen, Lu Lin

et al.

Biomedical Materials, Journal Year: 2025, Volume and Issue: 20(2), P. 025020 - 025020

Published: Jan. 29, 2025

The reconstruction of large-sized soft tissue defects remains a substantial clinical challenge, with adipose engineering emerging as promising solution. acellular dermal matrix (ADM), known for its intricate spatial arrangement and active cytokine involvement, is widely employed scaffold in engineering. Since ADM shares high similarity decellularized matrix, it holds potential substitute tissue. This study explores the adipogenic ability spongy material derived from via vacuum-thermal crosslinking (T-ADM), characterized by porosity, adjustable thickness, suitable mechanical strength. Adipose-derived stem cells (ADSCs) are considered ideal seed Nevertheless, whether pre-adipogenic induction necessary before their incorporation debatable. In this context, ADSCs, both without induction, were seeded into T-ADM to regenerate vascularized A comparative analysis two constructs was performed evaluate angiogenesis adipogenesisin vitro, regeneration efficacyin vivo. Additionally, RNA-seq utilized investigate mechanisms. results showed that exhibited good performance terms volume retention maintenance adipocyte phenotype, confirming suitability engineering.In-vitrooutcomes demonstrated enhanced level but reduced promote vascularization. Furthermore, utilizing pre-induced ADSCs an insignificant superiority inin-vivofat formation, neovascularization compared those non-induced which may be attributed similar macrophage regulation, balanced modulation proliferator-activated receptor-γand hypoxia-inducible factor 1αpathways. Consequently, direct use advocated streamline process reduce associated costs. combined strategy proves feasible, convenient effective, offering addressing deficits facilitating applications.

Language: Английский

Citations

0