BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 30, 2024
Sarcopenia has been shown to be an important condition with the ability predict negative health outcomes, especially in hospitalized older adults; hence, its accurate identification role prognosis of patients.
Language: Английский
Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(3), P. 454 - 499
Published: Jan. 30, 2024
Steatotic liver disease (SLD) displays a dynamic and complex phenotype. Consequently, the metabolic dysfunction-associated steatotic (MASLD)/metabolic steatohepatitis (MASH) therapeutic pipeline is expanding rapidly in multiple directions. In parallel, non-invasive tools for diagnosing monitoring responses to interventions are being studied, clinically feasible findings explored as primary outcomes interventional trials. The realization that distinct subgroups exist under umbrella of SLD should guide more precise personalized treatment recommendations facilitate advancements pharmacotherapeutics. This review summarizes recent updates pathophysiology-based nomenclature outlines both effective pharmacotherapeutics those MASLD/MASH, detailing their mode action current status phase 2 3 clinical Of extensive arsenal MASLD/MASH pipeline, several have been rejected, whereas other, mainly monotherapy options, shown only marginal benefits now tested part combination therapies, yet others still development monotherapies. Although successful drug candidate (or combinations) remains elusive, such approaches will ideally target MASH fibrosis while improving cardiometabolic risk factors. Due urgent need novel strategies potential availability safety tolerability data, repurposing existing approved drugs an appealing option. Finally, it essential highlight and, by extension, MASLD be recognized approached systemic affecting organs, with vigorous implementation interdisciplinary coordinated plans. Significance Statement SLD, including, among others, MASH, considered most prevalent chronic condition than one-fourth global population. aims provide information regarding pathophysiology, diagnosis, management line guidelines Collectively, hoped provided furthers understanding state direct implications stimulates additional research initiatives.
Language: Английский
Citations
31
Metabolism, Journal Year: 2023, Volume and Issue: 147, P. 155676 - 155676
Published: Aug. 4, 2023
Language: Английский
Citations
36
Metabolism, Journal Year: 2023, Volume and Issue: 149, P. 155711 - 155711
Published: Oct. 21, 2023
Language: Английский
Citations
26
Published: Aug. 12, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.
Language: Английский
Citations
13
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320079 - e0320079
Published: March 19, 2025
Physical functioning refers to the ability perform daily living activities, namely basic instrumental, and advanced activities. Poorer performance in these areas may indicate potential presence of sarcopenia. To analyze differences physical function between older people with without sarcopenia investigate associations tests A cross-sectional study based on data from Northern region Brazil year 2018 was conducted. Study participants included 312 aged ≥ 60 years (64.1% female). Sarcopenia defined using updated criteria European Working Group Older People (EWGSOP2). measured functional fitness (30-second chair stand test, sit-and-reach 8-foot Up-and-Go Test, 6-minute walk 4-meter gait speed, Fullerton Advanced Balance Scale). Confirmed detected 29.2% participants, but no participant had severe Most parameters crude analysis were associated confirmed (all p < 0.05), except for back scratch test. In a model adjusted sex, age body mass index, slower speed (OR = 1.29, 95%CI 1.08 1.54), up-and-go test time 1.32, 1.16 1.49), greater 0.97, 0.94 0.99) higher self-reported Composite Function scores 0.94, 0.89 significantly status. EWGSOP2 is prevalent residing Brazil's independently walking rising ability, reduced trunk lower-limb flexibility, as well poorer function.
Language: Английский
Citations
1
Metabolism, Journal Year: 2023, Volume and Issue: 145, P. 155595 - 155595
Published: May 26, 2023
Language: Английский
Citations
19
Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096
Published: Sept. 13, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.
Language: Английский
Citations
6
Metabolism, Journal Year: 2024, Volume and Issue: 158, P. 155972 - 155972
Published: July 6, 2024
Language: Английский
Citations
5
The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(8), P. 100290 - 100290
Published: June 21, 2024
An age-dependent normative values of calf circumference (CC) has been recently proposed as an accessible proxy for muscle mass. However, its usefulness to estimate sarcopenia not assessed. The objectives the present study were determine if substitution classical way assess mass by these have enough diagnostic accuracy and prognostic value among older adults living in community.
Language: Английский
Citations
4
Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: 27(5), P. 402 - 409
Published: July 18, 2024
Sarcopenic obesity is a likely common, but certainly underestimated phenotype, with an important negative clinical impact. Its definition and diagnosis have however remained elusive until recently.
Language: Английский
Citations
4