The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 30, 2024

Although previous studies have identified specific circulating inflammatory markers associated with the risk of mortality, they often overlooked broader impact a comprehensive response on health outcomes. This study aims to assess association between systemic inflammation and age-related hospitalization premature death, as well explore potential mediating effects various dietary patterns these associations.

Language: Английский

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Role of Cardiovascular Health in the Bidirectional Progression Trajectories Between Cardiovascular Disease, Type 2 Diabetes, and Cancer

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

There existed bidirectional associations of cardiovascular disease (CVD) and type 2 diabetes (T2D) with cancer, partly attributed to their shared risk factors. We aimed explore the role health (CVH) in transitions between CVD, T2D, cancer. Based on UK Biobank, we used subcohorts: a disease-free cohort 277 997 individuals without T2D; survivor consisting 61 971 cases T2D at baseline. The CVH was assessed basis Life's Essential 8 score. conducted multistate model Cox proportional hazards cancer cohorts, respectively. High significantly associated lower transition from CVD (hazard ratio, 0.822 [95% CI, 0.693-0.975]). On other hand, increased related reduced risks progression (both P for trend<0.001), particularly high group. For per 10-point increase >10% cases, 16% 42% reduction incident among survivors, decreased This highlighted significance maintaining throughout life span primary prevention

Language: Английский

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Diabetes and Cancer: A Twisted Bond

Oncology Reviews, Journal Year: 2024, Volume and Issue: 18

Published: May 21, 2024

This paper presents an overview of the interconnection between various factors related to both cancer and type 2 diabetes mellitus (T2DM). Hyperglycemia, hyperinsulinemia, chronic inflammation, obesity are involved in development progression diseases but, strong evidence for a direct causal relationship cancer, is lacking. Several studies described hyperglycemia at cellular, tissular organismic levels but same time recent Mendelian randomization proved significant only breast cancer. On other hand, association hyperinsulinemia several types appears be robust as demonstrated by randomized studies. Metabolic alterations, including Warburg effect excessive glucose consumption tumors, discussed, highlighting potential impact dietary restrictions, such fasting low-carb diets, on tumor growth inflammation. Recent data indicates that circulating branched-chain amino acids levels, may represent novel biomarkers contribute better control early pancreatic detection. Understanding underlying mechanisms shared risk T2DM can provide valuable insights prevention, detection, management strategies.

Language: Английский

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Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 809 - 823

Published: Feb. 1, 2024

Abstract: The incidences of thyroid cancer and diabetes are rapidly increasing worldwide. relationship between is a popular topic in medicine. Increasing evidence has shown that increases the risk to certain extent. This mechanism may be related genetic factors, abnormal thyroid-stimulating hormone secretion, oxidative stress injury, hyperinsulinemia, elevated insulin-like growth factor-1 levels, secretion adipocytokines, increased inflammatory factors chemokines. article reviews latest research progress on diabetes, including association developing cancer, its underlying mechanisms, potential anti-thyroid effects hypoglycemic drugs. It providing novel strategies for prevention, treatment, improving prognosis cancer. Keywords: drugs

Language: Английский

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Association of healthy sleep pattern with lower risk of acute myocardial infarction mortality among people with diabetes: A prospective cohort study

Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(4)

Published: April 1, 2024

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Language: Английский

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Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 13, 2024

Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), common complication and leading cause death. Persistent micro-inflammation is unique feature MHD. Given the established role inflammation in pathogenesis atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent factors for CVD MHD patients. A cross-sectional survey was conducted on from three dialysis centers, categorized into non-CVD group based medical history, laboratory tests, physical examination. Fasting blood samples were collected all participants indicator testing. The analysis 209 revealed that 104 had concurrent CVD. Patients significantly older exhibited anxiety depression scores. Forward stepwise multivariate logistic regression results identified index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082–1.491, P < 0.05) systemic immune-inflammation (SII) 1.001, 1.0001–1.002, Receiver operating characteristic (ROC) curve demonstrated SII, platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), NLR possess predictive diagnostic values events patient population. Hemodialysis centers utilize simple cost-effective proactively identify Future research how contributes required.

Language: Английский

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Association between walking pace and risks of major chronic diseases in individuals with hypertension based on a prospective study in UK biobank: Involvement of inflammation

Preventive Medicine, Journal Year: 2024, Volume and Issue: 184, P. 107986 - 107986

Published: May 5, 2024

Language: Английский

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Yetişkin Kadınlarda Pişirme ve Yiyecek Hazırlama Becerilerinin Diabetes Mellitus Riski ile İlişkisi

Turkish Journal of Diabetes and Obesity, Journal Year: 2024, Volume and Issue: 8(3), P. 277 - 286

Published: Dec. 30, 2024

Amaç: Bu çalışma, yemek hazırlama görevini sıklıkla kadınların üstlendiği toplumumuzda pişirme ve yiyecek becerileri ile diyabet riski arasındaki ilişkinin incelenmesi amacıyla yapılmıştır. Gereç Yöntemler: Çalışmaya yaşları 19-64 yıl arasında değişen 254 kadın katılmıştır. Beyana dayalı alınan vücut ağırlığı boy uzunluğu bilgileri kullanılarak beden kütle indeksi (BKİ) hesaplanmıştır. Veriler araştırmacı tarafından hazırlanan anket formu toplanmıştır. Anket formunda sosyodemografik bilgileri, Finlandiya Diyabet Riski Anketi (FINDRISK) Pişirme Yiyecek Hazırlama Becerileri Ölçeği yer almaktadır. Verilerin analizinde bağımsız örneklem t testi Pearson Ki-Kare uygulanmıştır. Basit Doğrusal Çoklu Regresyon modeli veriler ilişki incelenmiştir. İstatistiksel anlamlılık p

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