Microbiology Spectrum,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Dec. 11, 2024
ABSTRACT
The
connection
between
the
gut
mycobiome
and
atherosclerotic
cardiovascular
disease
(ACVD)
is
largely
uncharted.
In
our
study,
we
compared
fungal
communities
of
214
ACVD
patients
with
those
171
healthy
controls
using
shotgun
metagenomic
sequencing
examined
their
interactions
bacterial
network
key
taxa.
composition
in
significantly
different,
showing
a
rise
opportunistic
pathogens
like
Candida
albicans
,
Exophiala
spinifera
Malassezia
restricta
most
significant
changes
(Wilcoxon
rank-sum
test,
P
<
0.001,
fold
change
>10).
Network
analysis
revealed
less
interconnected
more
uneven
microbial
patients.
taxa
identified
microbiome
include
globosa
c182,
Nakaseomyces
glabratus
c88,
arunalokei
c192,
Penicillium
sumatraense
c22.
Predictive
models
that
integrated
both
enhanced
prediction
accuracy,
underscoring
critical
role
fungi
ACVD.
Our
findings
offer
thorough
understanding
link
progression,
which
vital
for
directing
future
therapeutic
research.
IMPORTANCE
leading
cause
death
morbidity
worldwide.
While
development
recognized,
contribution
remains
unexplored.
study
reveals
alterations
identifies
associated
disease.
These
underscore
importance
pathogenesis
new
avenues
developing
preventive
strategies
targeting
community.
results
provide
valuable
insights
into
complex
interplay
bacteria
ACVD,
paving
way
novel
approaches.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1104 - 1104
Published: Jan. 27, 2025
Chronic
inflammation
is
a
confirmed
risk
factor
for
colorectal
cancer
(CRC).
Indicators
of
systemic
inflammatory
response
(SIR),
such
as
neutrophil-to-lymphocyte
ratio
(NLR)
or
platelet-to-lymphocyte
(PLR),
are
easily
accessible
indicators
the
generalized
response.
At
molecular
level,
inflammation-related
carcinogenesis
involves
proteins
from
adamalysin
family:
ADAM10
and
ADAM17.
The
aim
study
was
to
assess
NLR
PLR
their
relationship
with
selected
clinical
parameters
in
CRC
patients,
well
correlation
between
ADAM17
tumor
tissue
matched
surgical
margins
values.
Tumor
material
margins,
blood
collected
66
patients
who
underwent
surgery
because
CRC.
concentrations
were
tested
using
enzyme-linked
immunosorbent
assay
(ELISA)
method.
SIR
(NLR,
PLR)
also
determined.
results
statistically
analyzed
compared
parameters.
Results:
showed
that
lower
comorbid
cardiovascular
diseases
(CVD).
In
preoperative
treatment,
both
values
higher
than
primary
surgery.
There
negative
margin
conclusion,
presence
additional
CVD
diabetes
mellitus
type
2
(DMT2)
use
treatment
should
be
taken
into
account
when
assessing
patients.
Moreover,
no
clear
correlations
have
been
found
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 17, 2025
To
investigate
the
possible
association
between
pan-immune-inflammation
value
(PIV)
and
dyslipidemia.
This
cross-sectional
study
used
data
obtained
from
National
Health
Nutrition
Examination
Survey
(NHANES).
The
independent
variable
logarithmic
form
of
PIV-log2
(PIV).
definition
dyslipidemia
was
based
on
Cholesterol
Education
Program
standards.
Weighted
multivariate
logistic
regression
analyses,
restricted
cubic
spline
(RCS)
threshold
effect
analysis
were
explore
PIV
Stratified
analyses
to
identify
potential
associations
with
other
covariates.
receiver
operating
characteristic
(ROC)
curve
constructed
compared
systemic
immune-inflammation
index
(SII).
6,821
participants
included,
whom
47%
male
77%
had
After
adjusting
for
all
confounders,
an
significantly
positive
(OR
(95%CI):
1.13
(1.01-1.25);
P
=
0.03).
Compared
lowest
quartile
(Q1)
PIV,
highest
(Q4)
a
higher
risk
1.37
(1.05-1.80);
0.022).
RCS
showed
inverted
J-shaped
relationship
(P-nonlinear
0.0415,
P-overall
<
0.001).
revealed
that
inflection
point
9.192.
age
BMI
modified
PIV-dyslipidemia
(P
interaction
0.05).
ROC
found
SII,
similar
predictive
(area
under
(AUC):
0.566
vs
0.558;
0.073).
discovered
dyslipidemia,
especially
in
young
overweight
individuals.
ABSTRACT
The
immune
microenvironment
includes
cells,
cytokines,
extracellular
matrix,
vesicles,
etc.
interactions
between
these
components
form
a
unique
local
microecology.
Although
immunity
serves
as
the
defense
against
external
pathogens,
aberrant
activation
often
contributes
to
disease
development.
Chronic
diseases,
broad
category
of
noncommunicable
conditions
characterized
by
long
latency
and
prolonged
course,
are
increasingly
recognized
for
their
intricate
relationship
with
microenvironment.
Herein,
we
comprehensively
summarize
how
microenvironment,
through
its
complex
regulatory
network,
influences
progression
manifestation
chronic
diseases.
We
further
explore
potential
targeting
therapeutic
strategy,
aiming
provide
new
insights
directions
prevention,
diagnosis,
treatment
Biomedical Chromatography,
Journal Year:
2025,
Volume and Issue:
39(7)
Published: May 21, 2025
ABSTRACT
Inflammation
plays
a
pivotal
role
in
the
pathogenesis
of
numerous
chronic
inflammatory
diseases,
including
cardiovascular
diseases.
Buyang
Huanwu
decoction
(BYHWD)
is
widely
employed
to
treat
inflammation
and
related
disorders.
However,
pharmacokinetics
BYHWD's
active
compounds
under
conditions
remain
unclear.
This
study
aims
investigate
comparative
eight
bioactive
components
control
LPS‐induced
rats
following
oral
administration
BYHWD.
A
rat
model
was
established
by
administering
low‐dose
lipopolysaccharide
(LPS,
200
μg
/
kg)
via
tail
vein
injection.
An
ultra‐performance
liquid
chromatography–tandem
mass
spectrometry
(UPLC‐MS/MS)
method
developed
for
simultaneous
quantification
major
BYHWD
plasma.
Subsequently,
pharmacokinetic
profiles
these
analytes
were
characterized
both
rats.
Excellent
linearity
(
R
2
>
0.9958)
observed
all
plasma
samples.
Absolute
recoveries
ranged
from
50.84%
111.86%,
matrix
effects
varied
between
85.04%
110.14%.
The
met
criteria
intra‐
inter‐day
precision,
accuracy,
stability.
In
conclusion,
UPLC‐MS/MS
reliably
investigated
characteristics
indicate
that
may
reduce
absorption
compounds,
providing
valuable
insights
into
clinical
applications.
