Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease DOI Creative Commons
Guangming Su, Ping Huang, Dan Liu

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 11, 2024

ABSTRACT The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared fungal communities of 214 ACVD patients with those 171 healthy controls using shotgun metagenomic sequencing examined their interactions bacterial network key taxa. composition in significantly different, showing a rise opportunistic pathogens like Candida albicans , Exophiala spinifera Malassezia restricta most significant changes (Wilcoxon rank-sum test, P < 0.001, fold change >10). Network analysis revealed less interconnected more uneven microbial patients. taxa identified microbiome include globosa c182, Nakaseomyces glabratus c88, arunalokei c192, Penicillium sumatraense c22. Predictive models that integrated both enhanced prediction accuracy, underscoring critical role fungi ACVD. Our findings offer thorough understanding link progression, which vital for directing future therapeutic research. IMPORTANCE leading cause death morbidity worldwide. While development recognized, contribution remains unexplored. study reveals alterations identifies associated disease. These underscore importance pathogenesis new avenues developing preventive strategies targeting community. results provide valuable insights into complex interplay bacteria ACVD, paving way novel approaches.

Language: Английский

Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations DOI Creative Commons

Fengyuan Lu,

En Li, Xiaoyu Yang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 critical in liver low-density lipoprotein receptors (LDLRs) metabolism. In addition to its hepatocellular presence, has also been detected cardiac, cerebral, islet, renal, adipose, and other tissues. Once perceived as a “harmful factor,” focal point for the targeted inhibition of both systemic circulation localized tissues treat diseases. However, contributes maintenance normal physiological functions numerous extrahepatic tissues, encompassing LDLR-dependent -independent pathways. Consequently, deficiency may harm close association with several pathophysiological processes, such lipid accumulation, mitochondrial impairment, insulin resistance, abnormal neural differentiation. This review encapsulates beneficial effects on processes potential disorders arising from provides comprehensive analysis disparities between experimental clinical research findings regarding associated deficiency. The aim improve current understanding diverse inhibition.

Language: Английский

Citations

1

Life's essential 8 and cardiovascular diseases progression among adults in the United Kingdom DOI
Huangda Guo,

Siyue Wang,

Hexiang Peng

et al.

Metabolism, Journal Year: 2024, Volume and Issue: unknown, P. 156031 - 156031

Published: Sept. 1, 2024

Language: Английский

Citations

0

Random Forest Analysis of Out-of-Pocket Health Expenditures Associated with Cardiometabolic Diseases, Lifestyle, Lipid Profile, and Genetic Information in São Paulo, Brazil DOI Open Access
Jean Michel Rocha Sampaio Leite, Lucas Akio Iza Trindade, Jaqueline Lopes Pereira

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(22), P. 2275 - 2275

Published: Nov. 14, 2024

There is a lack of empirical studies out-of-pocket health expenditures associated with dyslipidemias, which are major cardiovascular risk factors, especially in underrepresented admixed populations. The study investigates associations costs lipid traits, GWAS-derived genetic scores (GRSs), and other cardiometabolic factors.

Language: Английский

Citations

0

Childhood obesity and risk of inflammatory bowel disease in adulthood: A Mendelian randomization study DOI Creative Commons
Zhe Luan, Jing Wang, Zhizhuang Joe Zhao

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(48), P. e40478 - e40478

Published: Nov. 29, 2024

It is well-known that childhood obesity associated with various adult gastrointestinal diseases, inflammatory bowel disease (IBD) being no exception. However, previous epidemiological observational studies, while reporting a correlation between the 2, have left question of causal relationship inconclusive. This study aims to use 2-sample Mendelian randomization (MR) analysis assess and IBD as well its subtypes (ulcerative colitis [UC] Crohn [CD]). Data on obesity, IBD, (UC CD) were sourced from IEU OpenGWAS (https://gwas.mrcieu.ac.uk/datasets/ieu-a-1096/) IIBDGC (https://www.ibdgenetics.org/). The data analyzed using inverse variance weighted (IVW), MR-Egger, median, simple mode, mode methods. MR indicates or CD). consistency results across IVW, methods suggests reliability findings. We found not causally related differs prior studies. observed discrepancies may be due common biological environmental confounding factors.

Language: Английский

Citations

0

Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease DOI Creative Commons
Guangming Su, Ping Huang, Dan Liu

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 11, 2024

ABSTRACT The connection between the gut mycobiome and atherosclerotic cardiovascular disease (ACVD) is largely uncharted. In our study, we compared fungal communities of 214 ACVD patients with those 171 healthy controls using shotgun metagenomic sequencing examined their interactions bacterial network key taxa. composition in significantly different, showing a rise opportunistic pathogens like Candida albicans , Exophiala spinifera Malassezia restricta most significant changes (Wilcoxon rank-sum test, P < 0.001, fold change >10). Network analysis revealed less interconnected more uneven microbial patients. taxa identified microbiome include globosa c182, Nakaseomyces glabratus c88, arunalokei c192, Penicillium sumatraense c22. Predictive models that integrated both enhanced prediction accuracy, underscoring critical role fungi ACVD. Our findings offer thorough understanding link progression, which vital for directing future therapeutic research. IMPORTANCE leading cause death morbidity worldwide. While development recognized, contribution remains unexplored. study reveals alterations identifies associated disease. These underscore importance pathogenesis new avenues developing preventive strategies targeting community. results provide valuable insights into complex interplay bacteria ACVD, paving way novel approaches.

Language: Английский

Citations

0