Microbiology Spectrum,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Dec. 11, 2024
ABSTRACT
The
connection
between
the
gut
mycobiome
and
atherosclerotic
cardiovascular
disease
(ACVD)
is
largely
uncharted.
In
our
study,
we
compared
fungal
communities
of
214
ACVD
patients
with
those
171
healthy
controls
using
shotgun
metagenomic
sequencing
examined
their
interactions
bacterial
network
key
taxa.
composition
in
significantly
different,
showing
a
rise
opportunistic
pathogens
like
Candida
albicans
,
Exophiala
spinifera
Malassezia
restricta
most
significant
changes
(Wilcoxon
rank-sum
test,
P
<
0.001,
fold
change
>10).
Network
analysis
revealed
less
interconnected
more
uneven
microbial
patients.
taxa
identified
microbiome
include
globosa
c182,
Nakaseomyces
glabratus
c88,
arunalokei
c192,
Penicillium
sumatraense
c22.
Predictive
models
that
integrated
both
enhanced
prediction
accuracy,
underscoring
critical
role
fungi
ACVD.
Our
findings
offer
thorough
understanding
link
progression,
which
vital
for
directing
future
therapeutic
research.
IMPORTANCE
leading
cause
death
morbidity
worldwide.
While
development
recognized,
contribution
remains
unexplored.
study
reveals
alterations
identifies
associated
disease.
These
underscore
importance
pathogenesis
new
avenues
developing
preventive
strategies
targeting
community.
results
provide
valuable
insights
into
complex
interplay
bacteria
ACVD,
paving
way
novel
approaches.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 30, 2024
Proprotein
convertase
subtilisin/kexin
type
9
(PCSK9)
is
primarily
secreted
by
hepatocytes.
PCSK9
critical
in
liver
low-density
lipoprotein
receptors
(LDLRs)
metabolism.
In
addition
to
its
hepatocellular
presence,
has
also
been
detected
cardiac,
cerebral,
islet,
renal,
adipose,
and
other
tissues.
Once
perceived
as
a
“harmful
factor,”
focal
point
for
the
targeted
inhibition
of
both
systemic
circulation
localized
tissues
treat
diseases.
However,
contributes
maintenance
normal
physiological
functions
numerous
extrahepatic
tissues,
encompassing
LDLR-dependent
-independent
pathways.
Consequently,
deficiency
may
harm
close
association
with
several
pathophysiological
processes,
such
lipid
accumulation,
mitochondrial
impairment,
insulin
resistance,
abnormal
neural
differentiation.
This
review
encapsulates
beneficial
effects
on
processes
potential
disorders
arising
from
provides
comprehensive
analysis
disparities
between
experimental
clinical
research
findings
regarding
associated
deficiency.
The
aim
improve
current
understanding
diverse
inhibition.
Healthcare,
Journal Year:
2024,
Volume and Issue:
12(22), P. 2275 - 2275
Published: Nov. 14, 2024
There
is
a
lack
of
empirical
studies
out-of-pocket
health
expenditures
associated
with
dyslipidemias,
which
are
major
cardiovascular
risk
factors,
especially
in
underrepresented
admixed
populations.
The
study
investigates
associations
costs
lipid
traits,
GWAS-derived
genetic
scores
(GRSs),
and
other
cardiometabolic
factors.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(48), P. e40478 - e40478
Published: Nov. 29, 2024
It
is
well-known
that
childhood
obesity
associated
with
various
adult
gastrointestinal
diseases,
inflammatory
bowel
disease
(IBD)
being
no
exception.
However,
previous
epidemiological
observational
studies,
while
reporting
a
correlation
between
the
2,
have
left
question
of
causal
relationship
inconclusive.
This
study
aims
to
use
2-sample
Mendelian
randomization
(MR)
analysis
assess
and
IBD
as
well
its
subtypes
(ulcerative
colitis
[UC]
Crohn
[CD]).
Data
on
obesity,
IBD,
(UC
CD)
were
sourced
from
IEU
OpenGWAS
(https://gwas.mrcieu.ac.uk/datasets/ieu-a-1096/)
IIBDGC
(https://www.ibdgenetics.org/).
The
data
analyzed
using
inverse
variance
weighted
(IVW),
MR-Egger,
median,
simple
mode,
mode
methods.
MR
indicates
or
CD).
consistency
results
across
IVW,
methods
suggests
reliability
findings.
We
found
not
causally
related
differs
prior
studies.
observed
discrepancies
may
be
due
common
biological
environmental
confounding
factors.
Microbiology Spectrum,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Dec. 11, 2024
ABSTRACT
The
connection
between
the
gut
mycobiome
and
atherosclerotic
cardiovascular
disease
(ACVD)
is
largely
uncharted.
In
our
study,
we
compared
fungal
communities
of
214
ACVD
patients
with
those
171
healthy
controls
using
shotgun
metagenomic
sequencing
examined
their
interactions
bacterial
network
key
taxa.
composition
in
significantly
different,
showing
a
rise
opportunistic
pathogens
like
Candida
albicans
,
Exophiala
spinifera
Malassezia
restricta
most
significant
changes
(Wilcoxon
rank-sum
test,
P
<
0.001,
fold
change
>10).
Network
analysis
revealed
less
interconnected
more
uneven
microbial
patients.
taxa
identified
microbiome
include
globosa
c182,
Nakaseomyces
glabratus
c88,
arunalokei
c192,
Penicillium
sumatraense
c22.
Predictive
models
that
integrated
both
enhanced
prediction
accuracy,
underscoring
critical
role
fungi
ACVD.
Our
findings
offer
thorough
understanding
link
progression,
which
vital
for
directing
future
therapeutic
research.
IMPORTANCE
leading
cause
death
morbidity
worldwide.
While
development
recognized,
contribution
remains
unexplored.
study
reveals
alterations
identifies
associated
disease.
These
underscore
importance
pathogenesis
new
avenues
developing
preventive
strategies
targeting
community.
results
provide
valuable
insights
into
complex
interplay
bacteria
ACVD,
paving
way
novel
approaches.
