Sarcopenia and GERD

Experimental and Clinical Gastroenterology, Journal Year: 2025, Volume and Issue: 9, P. 119 - 125

Published: March 6, 2025

According to experts, sarcopenia, as a generalized progressive disorder of skeletal muscle function, will acquire the status global problem in near future, which is associated with an increase human life expectancy, and significance its main phenotypes (sarcopenic obesity, cachexia) beyond doubt. The results meta-analysis indicate that sarcopenic obesity significant predictor all-cause mortality among elderly, especially hospitalized patients. Cachexia cancer. Of particular interest are data on close relationship between GERD various sarcopenia. presented review demonstrates available date confirming this relationship. importance early diagnosis cachexia shown order possibly correct condition reduce rates. elderly.

Language: Английский

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Prognostic value of sarcopenia in patients with unresectable colorectal liver metastases after drug-eluting beads transcatheter arterial chemoembolization: a single center retrospective study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 1, 2025

Sarcopenia is a prevalent condition in tumor patients and can potentially impact the prognosis of treatment. This retrospective study aimed to evaluate correlations between sarcopenia with unresectable colorectal liver metastases (CRLM) received drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) therapy. From December 2018 2023, CRLM who had already second-line therapy from Wuhan Union Hospital were involved our study. Skeletal muscle mass was evaluated on CT at L3 vertebra, optimal cut-off point for skeletal index classification determined using x-tile software. Overall survival (OS) progression-free (PFS) estimated Kaplan–Meier analysis Cox regression analysis. Seventy-one included study, 34 (sarcopenia group) 37 without (non-sarcopenia group), respectively. The median PFS OS elevated non-sarcopenia group compared (6.1 months versus 4.3 months, p = 0.012; 14.8 10.2 < 0.001). multivariate revealed that sarcopenia, extrahepatic metastases, neutrophil-to-lymphocyte ratio (NLR) ≥ 5 identified as independent risk factors both OS. advantages terms consistent across all subgroups examined. Additionally, exhibited higher incidence vomiting/nausea, fatigue, abdominal pain following DEB-TACE operation group. demonstrated substantial predictive value underwent treatments. Besides, NLR > linked poorer prognosis. Furthermore, may face an increased likelihood experiencing adverse events

Language: Английский

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Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 1, 2025

Exercise combats obesity and metabolic disorders, but the underlying mechanism is incompletely understood. KLF10, a transcription factor involved in various biological processes, has an undefined role adipose tissue obesity. Here, we show that exercise facilitates adipocyte-derived KLF10 expression via SIRT1/FOXO1 pathway. Adipocyte-specific knockout of blunts exercise-promoted white browning, energy expenditure, fat loss, glucose tolerance diet-induced obese male mice. Conversely, adipocyte-specific transgenic mice enhanced above profits induced by exercise. Mechanistically, interacts with FOXO1 recruitment KDM4A to form ternary complex on promoter regions Pnpla2 Lipe genes promote these key lipolytic demethylating H3K9me3 their promoters, which lipolysis defend against As downstream effector responding exercise, could act as potential target fight The exercise-mediated anti-obesity effects not clear. authors exercise-induced recruits transactivate genes, defends

Language: Английский

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Leg and hip muscles show muscle‐specific effects of ageing and sport on muscle volume and fat fraction in male Masters athletes

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Age‐related deterioration in muscle volume, intramuscular fat content and function can be modulated by physical activity. We explored whether Masters athletes, as examples of highly physically active people into old age, could prevent these age‐related deteriorations. Four groups 43 men were examined: young athletes (20–35 years, n = 10), (60–75 10) two age‐matched control (old: 11, young: 12). Volumes fractions 17 different hip leg muscles determined using magnetic resonance imaging. In the soleus extra‐ intramyocellular lipids measured 1H‐MR‐spectroscopy. Finally volumes glutei, quadriceps triceps surae cumulated compared to peak jumping power. both age sum showed larger (young: 5758 ± 1139 ml, old: 5285 895 ml) corresponding 4781 833 4379 612 ( p < 0.001). Fat fraction varied between 1.5% 12.5% 1 H‐signal across was greater than 0.001), but lower that controls 0.001) comparable with controls. Age exercise‐related effects on predominantly originated from extramyocellular lipids. power per volume effectively halved combined older younger groups. Our findings suggest sarcosthenia, is, intrinsic weakness, is an effective cause declines addition sarcopenia accumulation. image Key points Muscle controls, imaging (MRI) a six‐point‐DIXON sequence. partially smaller athletes. higher Muscles produce only 50% subjects. The reduction loss not explained muscle.

Language: Английский

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Chronicity of obesity and the importance of early treatment to reduce cardiometabolic risk and improve body composition

Obesity Pillars, Journal Year: 2025, Volume and Issue: unknown, P. 100175 - 100175

Published: April 1, 2025

Language: Английский

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