Food Science and Biotechnology, Journal Year: 2024, Volume and Issue: 34(4), P. 1015 - 1026
Published: Oct. 6, 2024
Language: Английский
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: March 20, 2024
Abstract Background Dyslipidemia and abnormalities in cholesterol metabolism are commonly observed individuals with gallstone disease. Previous research has demonstrated that dietary magnesium can influence lipid metabolism. The atherogenic index of plasma (AIP) emerged as a novel marker. This study aimed to examine the possible correlation between intake gallstones potential mediating role AIP US adults. Methods A total 4,841 adults were included this from National Health Nutrition Examination Survey (NHANES) conducted 2017 2020. variety statistical techniques such logistic regression, subgroup analysis, smoothed curve fitting, causal mediation analysis utilized analyze information collected participants. Results In fully adjusted model, statistically noteworthy inverse relationship was presence gallstones, indicated by an odds ratio (OR) 0.58 95% confidence interval (CI) (0.42, 0.81). Causal intermediary revealed association partially mediated AIP, 3.2%. Conclusion According study, had significant linear negative prevalence which played role. discovery offers perspectives on prevention management gallstones.
Language: Английский
Citations
11
Journal of Clinical and Translational Hepatology, Journal Year: 2025, Volume and Issue: 000(000), P. 000 - 000
Published: Feb. 11, 2025
Background and AimsCholesterol synthesis gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is metabolite gut microbiota. However, the underlying mechanisms TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore specific molecular through TMAO promotes formation.
Language: Английский
Citations
0
Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 867 - 867
Published: March 3, 2025
The consumption of an unbalanced diet, such as a high-fat is strongly associated with hyperlipidemia and significantly contributes to the development cardiovascular cerebrovascular diseases, which are leading causes death worldwide. Globally, about 17.9 million people die disease each year (WHO 2023). Probiotics have emerged promising intervention alleviate hyperlipidemia. Therefore, this study investigates effects Lactobacillus fermentum 166 (LF-166), isolated from yak yogurt in Sichuan Tibetan area, on lipid metabolism liver gut microbiota high-fat-diet-induced hyperlipidemic mice. results revealed that (LF-166) treatment reduced body weight decreased blood levels these Based histopathological findings, LF-166 could steatosis colon injury. Additionally, 16S rRNA sequencing mice's colonic contents showed Firmicutes/Bacteroidetes (F/B) value enhanced richness diversity microbiota. regulated hepatic through up-regulation genes Lxr, Ampkα, Fxr, Hsl, Atgl down-regulation C/ebpα Pparγ liver; it also intestinal by up-regulating Abcg5 Abcg8 ileum down-regulating expression Npc1l1, Asbt, Ibabp. Thus, may inhibit progression modulating key involved metabolism, influencing liver-gut axis, regulating systemic metabolism.
Language: Английский
Citations
0
Cancer Treatment and Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 100899 - 100899
Published: March 1, 2025
To investigate the effect and molecular mechanism of ezetimibe on colorectal cancer (CRC), our study found that significantly inhibited proliferation progression CRC. Further showed RPS6KA2 might be target gene treatment expression was lower in human CRC tissue samples associated with T classification vascular invasion tumor cells. proliferation, migration, The underlying mechanisms indicated interaction between PCSK9 observed within cytoplasmic compartment suppressed MAPK signaling pathway BI-D1780 which is an inhibitor increased related proteins SW620 However, or stimulator did not affect expression, respectively. In vivo, cells overexpression could inhibit promote growth metastasis, promoted higher N TNM stage conclusion, firstly suggests suppresses by upregulating while downregulating PCSK9/MAPK pathway.
Language: Английский
Citations
0
Biologics, Journal Year: 2025, Volume and Issue: Volume 19, P. 113 - 123
Published: March 1, 2025
This study investigates the role of DNA topoisomerase IIα (TOP2A) in retinoblastoma (RB), focusing on its involvement epithelial-mesenchymal transition (EMT) and potential TOP2A inhibition as a therapeutic strategy. We analyzed expression RB tissues using public gene databases (GSE97508, GSE110811, GSE172170) conducted functional assays human cell lines (Y79 WERI-Rb-1) modified to knock down or overexpress TOP2A. Assessments included proliferation, migration, invasion, EMT marker via RT-PCR Western blot. Additionally, we evaluated effects modulation subcutaneous liver metastasis mouse xenograft models. was significantly overexpressed (p < 0.0001). In vitro, knockdown inhibited reversed 0.05), while overexpression enhanced these oncogenic processes. vivo, reduced tumor growth both models 0.05). Combination therapy with inhibitors further anti-tumor effects, reducing burden metastatic lesions 0.01). is pivotal pathogenesis progression, primarily by regulating EMT. Its not only curtails proliferation but also reverses EMT, underscoring target. lays groundwork for exploration TOP2A-targeted therapies RB.
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118165 - 118165
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119365 - 119365
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 30, 2025
With the increasing annual production of Lentinula edodes , residues Lentinus are mass produced and wasted every year. In order to further explore added value effective utilization we studied lipid-lowering efficacy liver protective effect soluble dietary fiber in mice on high-fat diet. Project team from extracted fiber, its physicochemical properties, selected 30 male mice, randomly divided into normal group (N), high fat diet (F), add low dose (FL), medium (FM), (FH) five groups. After 4 weeks, assessed general state, organ conditions, status, blood parameters, expression hepatic lipid metabolism genes, mRNA levels key genes. The results showed that molecular weight is about 17.029 kDa, monosaccharides such as galactose, glucose mannitol connected by β-glycosidic bond. can effectively slow growth due diet, delay tissue lesions, reduce ALT, AST, ACP, LDL-C, TG, TV, FFA, SOD, GSH MDA, increase γ-GT, HDL-C CAT blood. decreased AMPKα SREBP-2 liver, increased PPARα, ACS, CPT1a, CYP7A1. It proved alleviate accumulation caused some extent, combat injury, oxidative stress pressure disorder provide an experimental basis for subsequent use reduction.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 26, 2025
The preprotein convertase, Bacillus subtilis protease/kexin type 9 serine protease (PCSK9), has garnered significant attention as a potential lipid lowering and therapeutic drug target for atherosclerosis (AS). Peroxisome proliferator-activated receptor alpha (PPARα) is expressed in various tissues crucial roles metabolism the inflammatory response; however, precise impact of PCSK9 on AS progression through its regulation PPARα remains uncertain. present study aimed to examine introducing stable liver transduction human derived with gain function D374Y mutation (PCSK9DY) into systemic knockout mice (PPARα−/−) plasma levels AS. Enzymatic assays were employed evaluate concentrations at time points, aortic plaque formation degree infiltration quantified. Subsequently, we validated our vivo results using mouse primary peritoneal macrophages (MPMs). Furthermore, AAV8.2-PPARα virus vector was transduced transgenic PCSK9(hPCSK9DY-Tg) by tail vein, changes level detected. PCSK9DY expression exacerbated symptoms hypercholesterolemia PPARα−/− mice. En face analysis quantification root sections demonstrated increase area Secretion cytokines elevated In vitro, recombinant hPCSK9 protein promotes foam cell secretion MPMs increasing SR-A TLR4/NF-κB pathway proteins. can reduce hPCSK9DY-Tg These finding demonstrate that notably facilitated inflammation. However, overexpression
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41745 - e41745
Published: March 7, 2025
Asymptomatic gallbladder and biliary tract calculus may make into symptomatic disease or bring anxiety for patients. The formation of gallstones was associated with genetic risk factors metabolic abnormalities. Genome-wide association studies (GWAS) data 1400 plasma metabolites (PMs) 91 circulating inflammatory cytokines (CICs) were obtained from the GWAS catalog, while without cholecystitis bile duct cholangitis retrieved IEU OpenGWAS project. causalities PMs CICs to asymptomatic cholecyst explored by 2-sample Mendelian randomization (MR) analysis. Furthermore, MR analyses implemented identified CICs. Following false discovery rate adjustment, significant causalities, including 6 5 on stone 48 gallstone, identified. Fibroblast growth factor 19 (FGF-19) aspartate/mannose ratio common protective calculus, Monocyte chemoattractant protein 2 (CCL-2) serve as a disease-promoting agent. Moreover, Bilirubin degradation product, C17H18N2O4 (1) levels, (Z,Z)/etiocholanolone glucuronide FGF-19 level, related TNF-related apoptosis-inducing ligand level. Based analysis, we multiple CICs, especially FGF-19, which affect calculus. partial could be downstream mediator These results contributed supporting previous provided evidence prevention management.
Language: Английский
Citations
0